Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis
In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis....
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| Veröffentlicht in: | Brain pathology (Zurich, Switzerland) Switzerland), 2003-04, Vol.13 (2), p.123-132 |
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| creator | Klein, Matthias Koedel, Uwe Pfister, Hans-Walter Kastenbauer, Stefan |
| description | In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose‐dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood‐labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis‐associated spiral ganglion neuronal necrosis rather than apop‐tosis (determined by morphology, TUNEL staining, and immunohistochemistry). |
| doi_str_mv | 10.1111/j.1750-3639.2003.tb00012.x |
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The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose‐dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood‐labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis‐associated spiral ganglion neuronal necrosis rather than apop‐tosis (determined by morphology, TUNEL staining, and immunohistochemistry).</description><identifier>ISSN: 1015-6305</identifier><identifier>EISSN: 1750-3639</identifier><identifier>DOI: 10.1111/j.1750-3639.2003.tb00012.x</identifier><identifier>PMID: 12744466</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Capillary Permeability ; Cell Death ; Cochlea - pathology ; Disease Models, Animal ; Ear, Inner - blood supply ; Ear, Inner - pathology ; Hearing Loss, Central - etiology ; Hearing Loss, Central - pathology ; In Situ Nick-End Labeling ; Labyrinthitis - complications ; Labyrinthitis - pathology ; Male ; Meningitis, Pneumococcal - complications ; Meningitis, Pneumococcal - pathology ; Neurons - pathology ; Rats ; Rats, Wistar ; Spiral Ganglion - pathology</subject><ispartof>Brain pathology (Zurich, Switzerland), 2003-04, Vol.13 (2), p.123-132</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5153-6b2759e9a0c71a974e6724f076fb70f9108641eafedbf9cd0ba6ca099a84310d3</citedby><cites>FETCH-LOGICAL-c5153-6b2759e9a0c71a974e6724f076fb70f9108641eafedbf9cd0ba6ca099a84310d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095810/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095810/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12744466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Matthias</creatorcontrib><creatorcontrib>Koedel, Uwe</creatorcontrib><creatorcontrib>Pfister, Hans-Walter</creatorcontrib><creatorcontrib>Kastenbauer, Stefan</creatorcontrib><title>Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis</title><title>Brain pathology (Zurich, Switzerland)</title><addtitle>Brain Pathol</addtitle><description>In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose‐dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood‐labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis‐associated spiral ganglion neuronal necrosis rather than apop‐tosis (determined by morphology, TUNEL staining, and immunohistochemistry).</description><subject>Animals</subject><subject>Capillary Permeability</subject><subject>Cell Death</subject><subject>Cochlea - pathology</subject><subject>Disease Models, Animal</subject><subject>Ear, Inner - blood supply</subject><subject>Ear, Inner - pathology</subject><subject>Hearing Loss, Central - etiology</subject><subject>Hearing Loss, Central - pathology</subject><subject>In Situ Nick-End Labeling</subject><subject>Labyrinthitis - complications</subject><subject>Labyrinthitis - pathology</subject><subject>Male</subject><subject>Meningitis, Pneumococcal - complications</subject><subject>Meningitis, Pneumococcal - pathology</subject><subject>Neurons - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spiral Ganglion - pathology</subject><issn>1015-6305</issn><issn>1750-3639</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU2P0zAQhiMEYpeFv4AiDtwSxnFixxyQumXZBWWhEiCOluNMWpckLnYC3X-PQ6suHPHFI807z3y8UfSCQErCe7VNCS8goYyKNAOg6VgDAMnS_YPo_JR6GGIgRcIoFGfRE--3QSOYKB5HZyTjeZ4zdh5tbq3bbWxn10arLl5a57BTI_rYtvFCTyPGamjiFbpeDTiM8Q0qZ4Z1XFnv47fTn_hqv0Nn-pAOiNWAU2-11TPvFocgMKPxT6NHreo8Pjv-F9HXd1dfljdJ9en6_XJRJbogBU1YnfFCoFCgOVGC58h4lrfAWVtzaAWBkuUEVYtN3QrdQK2YViCEKnNKoKEX0ZsDdzfVPTY6DOVUJ3dhPuXupFVG_psZzEau7U9ZgihKAgHw8ghw9seEfpS98Rq7LuxvJy85zcpw1zwIXx-E2oVbOGxPTQjI2Si5lbMbcnZDzkbJo1FyH4qf_z3mfenRmfs9fpkO7_4DLS9XC5LRAEgOAONH3J8Ayn2XjFNeyG8fr-XnqqwYy0v5gf4GGyC04w</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Klein, Matthias</creator><creator>Koedel, Uwe</creator><creator>Pfister, Hans-Walter</creator><creator>Kastenbauer, Stefan</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200304</creationdate><title>Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis</title><author>Klein, Matthias ; Koedel, Uwe ; Pfister, Hans-Walter ; Kastenbauer, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5153-6b2759e9a0c71a974e6724f076fb70f9108641eafedbf9cd0ba6ca099a84310d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Capillary Permeability</topic><topic>Cell Death</topic><topic>Cochlea - pathology</topic><topic>Disease Models, Animal</topic><topic>Ear, Inner - blood supply</topic><topic>Ear, Inner - pathology</topic><topic>Hearing Loss, Central - etiology</topic><topic>Hearing Loss, Central - pathology</topic><topic>In Situ Nick-End Labeling</topic><topic>Labyrinthitis - complications</topic><topic>Labyrinthitis - pathology</topic><topic>Male</topic><topic>Meningitis, Pneumococcal - complications</topic><topic>Meningitis, Pneumococcal - pathology</topic><topic>Neurons - pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spiral Ganglion - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Matthias</creatorcontrib><creatorcontrib>Koedel, Uwe</creatorcontrib><creatorcontrib>Pfister, Hans-Walter</creatorcontrib><creatorcontrib>Kastenbauer, Stefan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain pathology (Zurich, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Matthias</au><au>Koedel, Uwe</au><au>Pfister, Hans-Walter</au><au>Kastenbauer, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis</atitle><jtitle>Brain pathology (Zurich, Switzerland)</jtitle><addtitle>Brain Pathol</addtitle><date>2003-04</date><risdate>2003</risdate><volume>13</volume><issue>2</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>1015-6305</issn><eissn>1750-3639</eissn><abstract>In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis‐associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose‐dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood‐labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis‐associated spiral ganglion neuronal necrosis rather than apop‐tosis (determined by morphology, TUNEL staining, and immunohistochemistry).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12744466</pmid><doi>10.1111/j.1750-3639.2003.tb00012.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Capillary Permeability Cell Death Cochlea - pathology Disease Models, Animal Ear, Inner - blood supply Ear, Inner - pathology Hearing Loss, Central - etiology Hearing Loss, Central - pathology In Situ Nick-End Labeling Labyrinthitis - complications Labyrinthitis - pathology Male Meningitis, Pneumococcal - complications Meningitis, Pneumococcal - pathology Neurons - pathology Rats Rats, Wistar Spiral Ganglion - pathology |
| title | Morphological Correlates of Acute and Permanent Hearing Loss During Experimental Pneumococcal Meningitis |
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