Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical mode...

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Veröffentlicht in:	Nature medicine 2021-01, Vol.27 (1), p.152-164
Hauptverfasser:	Yu, Jiali, Green, Michael D., Li, Shasha, Sun, Yilun, Journey, Sara N., Choi, Jae Eun, Rizvi, Syed Monem, Qin, Angel, Waninger, Jessica J., Lang, Xueting, Chopra, Zoey, El Naqa, Issam, Zhou, Jiajia, Bian, Yingjie, Jiang, Long, Tezel, Alangoya, Skvarce, Jeremy, Achar, Rohan K., Sitto, Merna, Rosen, Benjamin S., Su, Fengyun, Narayanan, Sathiya P., Cao, Xuhong, Wei, Shuang, Szeliga, Wojciech, Vatan, Linda, Mayo, Charles, Morgan, Meredith A., Schonewolf, Caitlin A., Cuneo, Kyle, Kryczek, Ilona, Ma, Vincent T., Lao, Christopher D., Lawrence, Theodore S., Ramnath, Nithya, Wen, Fei, Chinnaiyan, Arul M., Cieslik, Marcin, Alva, Ajjai, Zou, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2504/342 631/67/322 631/67/580 692/699/67/1059/2325 Animal models Animals Antigens Apoptosis Biomarkers Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Non-Small-Cell Lung - therapy Care and treatment CD11b antigen CD8 antigen CD95 antigen Cell Line, Tumor Cell survival Clonal deletion Cohort Studies Combined Modality Therapy Fas antigen FasL protein Female Hepatocytes Humans Immune checkpoint inhibitors Immunological tolerance Immunotherapy Infectious Diseases Liver Liver cancer Liver Neoplasms - immunology Liver Neoplasms - secondary Liver Neoplasms - therapy Liver Neoplasms, Experimental - immunology Liver Neoplasms, Experimental - secondary Liver Neoplasms, Experimental - therapy Lymphocyte Activation Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Male Melanoma - immunology Melanoma - secondary Melanoma - therapy Metabolic Diseases Metastases Metastasis Methods Mice Mice, Inbred C57BL Mice, Transgenic Molecular Medicine Monocytes Neurosciences Patient outcomes Physiological aspects Radiation therapy Radiotherapy, Adjuvant Siphoning T cells T-Lymphocytes - classification T-Lymphocytes - immunology T-Lymphocytes - pathology Treatment Failure Treatment Outcome Tumor Microenvironment - immunology Tumor Microenvironment - radiation effects
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