A 24-YEAR-OLD MALE WITH HEADACHES
A 24-year-old man presented with a ten-day history of severe headache leading to collapse. CT studies showed filling defects involving the anterior, middle and posterior cerebral arteries and evidence of ischemia and infarction. Post-mortem examination revealed multiple cerebral infarcts secondary t...
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| Veröffentlicht in: | Brain pathology (Zurich, Switzerland) Switzerland), 2010-07, Vol.20 (4), p.863-866 |
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| container_title | Brain pathology (Zurich, Switzerland) |
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| creator | Chen, Zhongchuan Will Symons, Sean P. Young, Beverley Bilbao, Juan M. |
| description | A 24-year-old man presented with a ten-day history of severe headache leading to collapse. CT studies showed filling defects involving the anterior, middle and posterior cerebral arteries and evidence of ischemia and infarction. Post-mortem examination revealed multiple cerebral infarcts secondary to an arteritic process composed of multi-nucleated giant cells, lymphocytes and histiocytes in both middle and anterior cerebral arteries and one posterior cerebral artery. Both carotid siphons and one renal artery segment were also involved. Extensive workup and stains for systemic and infectious causes were negative, leading to a diagnosis of atypical giant cell arteritis (GCA). Disseminated GCA involving extracranial arteries and the anterior, middle and posterior cerebral arteries leading to cerebral infarction has not been previously reported. We report this atypical case of disseminated GCA in a young patient with clinical features distinct from classic GCA (temporal arteritis) and discuss the differential diagnosis. |
| doi_str_mv | 10.1111/j.1750-3639.2010.00403.x |
| format | Article |
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We report this atypical case of disseminated GCA in a young patient with clinical features distinct from classic GCA (temporal arteritis) and discuss the differential diagnosis.</description><identifier>ISSN: 1015-6305</identifier><identifier>EISSN: 1750-3639</identifier><identifier>DOI: 10.1111/j.1750-3639.2010.00403.x</identifier><identifier>PMID: 20626748</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Brain - diagnostic imaging ; Brain - pathology ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - etiology ; Cerebral Infarction - pathology ; Correspondence ; Fatal Outcome ; Giant Cell Arteritis - complications ; Giant Cell Arteritis - diagnostic imaging ; Giant Cell Arteritis - pathology ; Headache - diagnostic imaging ; Headache - etiology ; Headache - pathology ; Humans ; Male ; Radiography ; Young Adult</subject><ispartof>Brain pathology (Zurich, Switzerland), 2010-07, Vol.20 (4), p.863-866</ispartof><rights>2010 The Authors; Journal Compilation © 2010 International Society of Neuropathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4783-507c5af28780340d9919b0bf4e1112d203592f93fb0b8a13a6061d54dde54c2c3</citedby><cites>FETCH-LOGICAL-c4783-507c5af28780340d9919b0bf4e1112d203592f93fb0b8a13a6061d54dde54c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094715/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094715/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20626748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhongchuan Will</creatorcontrib><creatorcontrib>Symons, Sean P.</creatorcontrib><creatorcontrib>Young, Beverley</creatorcontrib><creatorcontrib>Bilbao, Juan M.</creatorcontrib><title>A 24-YEAR-OLD MALE WITH HEADACHES</title><title>Brain pathology (Zurich, Switzerland)</title><addtitle>Brain Pathol</addtitle><description>A 24-year-old man presented with a ten-day history of severe headache leading to collapse. CT studies showed filling defects involving the anterior, middle and posterior cerebral arteries and evidence of ischemia and infarction. Post-mortem examination revealed multiple cerebral infarcts secondary to an arteritic process composed of multi-nucleated giant cells, lymphocytes and histiocytes in both middle and anterior cerebral arteries and one posterior cerebral artery. Both carotid siphons and one renal artery segment were also involved. Extensive workup and stains for systemic and infectious causes were negative, leading to a diagnosis of atypical giant cell arteritis (GCA). Disseminated GCA involving extracranial arteries and the anterior, middle and posterior cerebral arteries leading to cerebral infarction has not been previously reported. We report this atypical case of disseminated GCA in a young patient with clinical features distinct from classic GCA (temporal arteritis) and discuss the differential diagnosis.</description><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - etiology</subject><subject>Cerebral Infarction - pathology</subject><subject>Correspondence</subject><subject>Fatal Outcome</subject><subject>Giant Cell Arteritis - complications</subject><subject>Giant Cell Arteritis - diagnostic imaging</subject><subject>Giant Cell Arteritis - pathology</subject><subject>Headache - diagnostic imaging</subject><subject>Headache - etiology</subject><subject>Headache - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Radiography</subject><subject>Young Adult</subject><issn>1015-6305</issn><issn>1750-3639</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkNtOwkAQhjdGI4i-gqkP0Dp7aruJMam0HLSKQQzxarL0oEVOaVHh7V1Eid65NzuZme_fzUeIRcGh5pyPHepJsLnLlcPAdAEEcGe1R-q7wb6pgUrb5SBr5KiqxgBUuUoekhoDl7me8OvkLLCYsJ-ioG_34tC6DeLIGnYHHasTBWHQ7EQPx-Qg15MqO_m-G-SxFQ2aHTvutbvNILYT4fncluAlUufM93zgAlKlqBrBKBeZ-TBLGXCpWK54bpq-ply74NJUijTNpEhYwhvkcpu7eBtNszTJZstST3BRFlNdrnGuC_w7mRUv-Dx_Rx-U8Kg0Af42ICnnVVVm-Y6lgBttOMaNHdzYwY02_NKGK4Oe_n57B_54MgsX24WPYpKt_x2MV_eBKQxub_GiWmarHa7LV3Q97kkc3rXRD-Owf9NSeM0_AfK3hX0</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Chen, Zhongchuan Will</creator><creator>Symons, Sean P.</creator><creator>Young, Beverley</creator><creator>Bilbao, Juan M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201007</creationdate><title>A 24-YEAR-OLD MALE WITH HEADACHES</title><author>Chen, Zhongchuan Will ; Symons, Sean P. ; Young, Beverley ; Bilbao, Juan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4783-507c5af28780340d9919b0bf4e1112d203592f93fb0b8a13a6061d54dde54c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Cerebral Infarction - etiology</topic><topic>Cerebral Infarction - pathology</topic><topic>Correspondence</topic><topic>Fatal Outcome</topic><topic>Giant Cell Arteritis - complications</topic><topic>Giant Cell Arteritis - diagnostic imaging</topic><topic>Giant Cell Arteritis - pathology</topic><topic>Headache - diagnostic imaging</topic><topic>Headache - etiology</topic><topic>Headache - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Radiography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhongchuan Will</creatorcontrib><creatorcontrib>Symons, Sean P.</creatorcontrib><creatorcontrib>Young, Beverley</creatorcontrib><creatorcontrib>Bilbao, Juan M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain pathology (Zurich, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhongchuan Will</au><au>Symons, Sean P.</au><au>Young, Beverley</au><au>Bilbao, Juan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 24-YEAR-OLD MALE WITH HEADACHES</atitle><jtitle>Brain pathology (Zurich, Switzerland)</jtitle><addtitle>Brain Pathol</addtitle><date>2010-07</date><risdate>2010</risdate><volume>20</volume><issue>4</issue><spage>863</spage><epage>866</epage><pages>863-866</pages><issn>1015-6305</issn><eissn>1750-3639</eissn><abstract>A 24-year-old man presented with a ten-day history of severe headache leading to collapse. CT studies showed filling defects involving the anterior, middle and posterior cerebral arteries and evidence of ischemia and infarction. Post-mortem examination revealed multiple cerebral infarcts secondary to an arteritic process composed of multi-nucleated giant cells, lymphocytes and histiocytes in both middle and anterior cerebral arteries and one posterior cerebral artery. Both carotid siphons and one renal artery segment were also involved. Extensive workup and stains for systemic and infectious causes were negative, leading to a diagnosis of atypical giant cell arteritis (GCA). Disseminated GCA involving extracranial arteries and the anterior, middle and posterior cerebral arteries leading to cerebral infarction has not been previously reported. We report this atypical case of disseminated GCA in a young patient with clinical features distinct from classic GCA (temporal arteritis) and discuss the differential diagnosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20626748</pmid><doi>10.1111/j.1750-3639.2010.00403.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain pathology (Zurich, Switzerland), 2010-07, Vol.20 (4), p.863-866 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Brain - diagnostic imaging Brain - pathology Cerebral Infarction - diagnostic imaging Cerebral Infarction - etiology Cerebral Infarction - pathology Correspondence Fatal Outcome Giant Cell Arteritis - complications Giant Cell Arteritis - diagnostic imaging Giant Cell Arteritis - pathology Headache - diagnostic imaging Headache - etiology Headache - pathology Humans Male Radiography Young Adult |
| title | A 24-YEAR-OLD MALE WITH HEADACHES |
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