miR-23a/b suppress cGAS-mediated innate and autoimmunity

Cyclic GMP-AMP synthase (cGAS), a key sensor of intracellular DNA, is essential for eliciting innate immunity against infection, whereas aberrant activation of cGAS by endogenous DNA promotes severe autoimmune diseases. However, it is largely unknown how cGAS expression is regulated during pathogen...

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Veröffentlicht in:	Cellular & molecular immunology 2021-05, Vol.18 (5), p.1235-1248
Hauptverfasser:	Yu, Qiuya, Chu, Lei, Li, Yongxing, Wang, Quanyi, Zhu, Juanjuan, Wang, Chen, Cui, Shufang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 631/250/38 AMP Animals Antibodies Autoimmune diseases Autoimmunity Base Sequence Biomedical and Life Sciences Biomedicine Cyclic GMP Cytosol - metabolism Deoxyribonucleic acid DNA DNA - metabolism Gene Expression Regulation HEK293 Cells Herpes simplex Herpes Simplex - immunology Herpes Simplex - pathology Herpes Simplex - virology Herpes viruses Herpesvirus 1, Human - physiology Humans Immune response Immunity, Innate Immunology Infections Innate immunity Interferon Type I - metabolism Male Medical Microbiology Mice Mice, Inbred C57BL Microbiology MicroRNAs - genetics MicroRNAs - metabolism miRNA Nucleotidyltransferases - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Vaccine
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