Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps

Rishirilides are a group of PKS II secondary metabolites produced by Streptomyces bottropensis Gö C4/4. Biosynthetic studies in the past have elucidated early and late steps of rishirilide biosynthesis. This work is aiming to solve the remaining steps in the rishirilide biosynthesis. Inactivation of...

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Veröffentlicht in:	Molecular biotechnology 2021-06, Vol.63 (6), p.502-514
Hauptverfasser:	Alali, Ahmad, Zhang, Lin, Li, Jianyu, Zuo, Chijian, Wassouf, Dimah, Yan, Xiaohui, Schwarzer, Philipp, Günther, Stefan, Einsle, Oliver, Bechthold, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - chemistry Anthracenes - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - genetics Biochemistry Biological Techniques Biosynthesis Biotechnology Cell Biology Chemistry Chemistry and Materials Science Crystal structure Cyclization Flavin mononucleotide Flavin reductase Human Genetics Inactivation Inspection Metabolites Molecular dynamics Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - ultrastructure Multigene Family - genetics Mutagenesis, Site-Directed Original Paper Oxygenation Polyketide Synthases - biosynthesis Polyketide Synthases - chemistry Polyketide Synthases - genetics Polyketide Synthases - ultrastructure Polyketides - chemistry Protein Science Quinones Reductases Secondary metabolites Similarity Site-directed mutagenesis Streptomyces Streptomyces - enzymology Substrates
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