GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture

The ability of HIV to integrate into the host genome and establish latent reservoirs is the main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that target the binding pocket of LEDGF/p75, a cellular cofactor that substantially contributes to HIV integration site sele...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-04, Vol.65 (5)
Hauptverfasser:	Bruggemans, Anne, Vansant, Gerlinde, Balakrishnan, Mini, Mitchell, Michael L, Cai, Ruby, Christ, Frauke, Debyser, Zeger
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents
Online-Zugang:	Volltext
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