Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly

Adeno-associated viruses (AAV) have attracted significant attention in the field of gene and cell therapy due to highly effective delivery of therapeutic genes into human cells. The ability to generate recombinant AAV vectors compromised of unique or substituted protein sequences has led to the deve...

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Veröffentlicht in:	Journal of virology 2021-03, Vol.95 (7)
Hauptverfasser:	Viney, Lydia, Bürckstümmer, Tilmann, Eddington, Courtnee, Mietzsch, Mario, Choudhry, Modassir, Henley, Tom, Agbandje-McKenna, Mavis
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Delivery Spotlight
Online-Zugang:	Volltext
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