A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures

Coiled-coil (CC) dimers are widely used in protein design because of their modularity and well-understood sequence–structure relationship. In CC protein origami design, a polypeptide chain is assembled from a defined sequence of CC building segments that determine the self-assembly of protein cages...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-04, Vol.118 (17), p.1-9
Hauptverfasser:	Majerle, Andreja, Hadži, San, Aupič, Jana, Satler, Tadej, Lapenta, Fabio, Strmšek, Žiga, Lah, Jurij, Loris, Remy, Jerala, Roman
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Antibodies Binding Biological Sciences Chains Coils Crystal structure Design Dimers Epitopes Modular design Modularity Modules Nanobodies Polyhedra Polypeptides Prisms Protein structure Proteins Self-assembly Small angle X ray scattering Stoichiometry Tetrahedra X-ray scattering
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