Local adaptation of Mycobacterium tuberculosis on the Tibetan Plateau

During its global dispersal, Mycobacterium tuberculosis (Mtb) has encountered varied geographic environments and host populations. Although local adaptation seems to be a plausible model for describing long-term host–pathogen interactions, genetic evidence for this model is lacking. Here, we analyze...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-04, Vol.118 (17), p.1-10
Hauptverfasser:	Liu, Qingyun, Liu, Haican, Shi, Li, Gan, Mingyu, Zhao, Xiuqin, Lyu, Liang-Dong, Takiff, Howard E., Wan, Kanglin, Gao, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Altitude Biological Sciences Deoxyribonucleic acid Dispersal DNA DNA repair Gene sequencing High altitude Mutation Mycobacterium tuberculosis Oxidative stress Oxidoreductase Population Population dynamics Population genetics Population structure Populations Positive selection Tuberculosis
Online-Zugang:	Volltext
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