Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of T cell receptor and cytokine signaling, Ptpn2, in the formation and function of TRM cells in skin. Ptpn2-deficient CD8+ T cells displayed a marked defect in generating C...

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Veröffentlicht in:	The Journal of experimental medicine 2021-06, Vol.218 (6)
Hauptverfasser:	Hochheiser, Katharina, Wiede, Florian, Wagner, Teagan, Freestone, David, Enders, Matthias H, Olshansky, Moshe, Russ, Brendan, Nüssing, Simone, Bawden, Emma, Braun, Asolina, Bachem, Annabell, Gressier, Elise, McConville, Robyn, Park, Simone L, Jones, Claerwen M, Davey, Gayle M, Gyorki, David E, Tscharke, David, Parish, Ian A, Turner, Stephen, Herold, Marco J, Tiganis, Tony, Bedoui, Sammy, Gebhardt, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity Infectious Disease and Host Defense
Online-Zugang:	Volltext
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