Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels
Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but...
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| Veröffentlicht in: | Journal of the Endocrine Society 2021-05, Vol.5 (Supplement_1), p.A39-A39 |
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| creator | Gonçalves, Vanessa Guerreiro Maia, Isabel Mendonça, Fernando Silva, Maria Manuel Neves, João Sérgio Pedro, Jorge Pires Salazar, Cristina Daniela Ferreira, Maria João Silva Costa, Cláudia Fernandes Canha, Marta Borges Lau, Eva Freitas, Paula Carvalho, Davide M |
| description | Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but the effect of basal serum triglycerides levels on this reversal is unknown. This study aimed to assess the association between preoperative triglycerides levels and pre- and type 2 diabetes mellitus remission in obese patients one year after bariatric surgery.
Methods: A retrospective study was conducted among 1959 obese patients who underwent bariatric surgery in our entre. Data on socio-demographic and clinical characteristics were used. Pre-diabetes and type 2 diabetes mellitus remission was defined as normal glycaemic measures at least one year’s duration without pharmacological therapy. Logistic regression models, crude and adjusted for sex, age, preoperative serum triglycerides levels and type of bariatric surgery, were used.
Results: The median of preoperative serum triglycerides level was 121.00 (SD=75.00) mg/dL, and 34.7% and 30.0% of patients presented pre- and type 2 diabetes mellitus, respectively, at baseline. Preoperative serum triglycerides levels were higher in type 2 diabetes mellitus patients (139.00 vs. 106.00 mg/dL, in normal glycaemic patients; p |
| doi_str_mv | 10.1210/jendso/bvab048.076 |
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| fullrecord | <record><control><sourceid>pubmedcentral_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8089763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_8089763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1426-782fff2c4979797a1cf1a1629fa16d12a2393fc7e342045e39036e99617fadb23</originalsourceid><addsrcrecordid>eNpVkd1qwkAQhZfSQsX6Ar3aF4juX5NsLwqt_QWLYuP1stnM6kpMZDcGQl--EaW0DMwMDOcchg-hW0rGlFEy2UJVhHqStzonIh2TJL5AAyYSFlGZsMs_-zUahbAlhFDJhRRigL6zbg-Y4Wenc2gg4E8oS9ccAl7CzoXg6gq7Cs9zCIAXunFQNQGvqgI8ftLe6cY7g78Ofg2-u8fZBvCyLgHXFi881HvwvaYFnHm3LjsD3hV9yAxaKMMNurK6DDA6zyFavb5k0_doNn_7mD7OIkMFi6MkZdZaZoRMjqWpsVTTmEnb94Iyzbjk1iTABSPiDrgkPAYpY5pYXeSMD9HDyXd_yHdQmP4Fr0u1926nfadq7dT_S-U2al23KiWpTGLeG7CTgfF1CB7sr5YSdUSgTgjUGYHqEfAfoxF_ag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford Journals Open Access Collection</source><source>PubMed Central</source><creator>Gonçalves, Vanessa Guerreiro ; Maia, Isabel ; Mendonça, Fernando ; Silva, Maria Manuel ; Neves, João Sérgio ; Pedro, Jorge Pires ; Salazar, Cristina Daniela ; Ferreira, Maria João Silva ; Costa, Cláudia Fernandes ; Canha, Marta Borges ; Lau, Eva ; Freitas, Paula ; Carvalho, Davide M</creator><creatorcontrib>Gonçalves, Vanessa Guerreiro ; Maia, Isabel ; Mendonça, Fernando ; Silva, Maria Manuel ; Neves, João Sérgio ; Pedro, Jorge Pires ; Salazar, Cristina Daniela ; Ferreira, Maria João Silva ; Costa, Cláudia Fernandes ; Canha, Marta Borges ; Lau, Eva ; Freitas, Paula ; Carvalho, Davide M</creatorcontrib><description>Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but the effect of basal serum triglycerides levels on this reversal is unknown. This study aimed to assess the association between preoperative triglycerides levels and pre- and type 2 diabetes mellitus remission in obese patients one year after bariatric surgery.
Methods: A retrospective study was conducted among 1959 obese patients who underwent bariatric surgery in our entre. Data on socio-demographic and clinical characteristics were used. Pre-diabetes and type 2 diabetes mellitus remission was defined as normal glycaemic measures at least one year’s duration without pharmacological therapy. Logistic regression models, crude and adjusted for sex, age, preoperative serum triglycerides levels and type of bariatric surgery, were used.
Results: The median of preoperative serum triglycerides level was 121.00 (SD=75.00) mg/dL, and 34.7% and 30.0% of patients presented pre- and type 2 diabetes mellitus, respectively, at baseline. Preoperative serum triglycerides levels were higher in type 2 diabetes mellitus patients (139.00 vs. 106.00 mg/dL, in normal glycaemic patients; p<0.001) and showed to be significantly correlated with fasting glycaemia, glycated
haemoglobin, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. One year after bariatric surgery, 62.5% of patients with pre- or type 2 diabetes at baseline showed remission. Preoperative serum triglycerides levels were negatively associated with this remission (OR: 0.997; 95%CI=0.995–0.998), independently of, sex, age and type of bariatric surgery. Conclusions: One year after bariatric surgery, 62.5% of patients showed pre- or type 2 diabetes mellitus remission, being the preoperative serum triglycerides levels an important clinical parameter for remission.
Keywords: triglycerides, diabetes, remission, obesity, bariatric surgery</description><identifier>ISSN: 2472-1972</identifier><identifier>EISSN: 2472-1972</identifier><identifier>DOI: 10.1210/jendso/bvab048.076</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adipose Tissue, Appetite, and Obesity</subject><ispartof>Journal of the Endocrine Society, 2021-05, Vol.5 (Supplement_1), p.A39-A39</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089763/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089763/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Gonçalves, Vanessa Guerreiro</creatorcontrib><creatorcontrib>Maia, Isabel</creatorcontrib><creatorcontrib>Mendonça, Fernando</creatorcontrib><creatorcontrib>Silva, Maria Manuel</creatorcontrib><creatorcontrib>Neves, João Sérgio</creatorcontrib><creatorcontrib>Pedro, Jorge Pires</creatorcontrib><creatorcontrib>Salazar, Cristina Daniela</creatorcontrib><creatorcontrib>Ferreira, Maria João Silva</creatorcontrib><creatorcontrib>Costa, Cláudia Fernandes</creatorcontrib><creatorcontrib>Canha, Marta Borges</creatorcontrib><creatorcontrib>Lau, Eva</creatorcontrib><creatorcontrib>Freitas, Paula</creatorcontrib><creatorcontrib>Carvalho, Davide M</creatorcontrib><title>Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels</title><title>Journal of the Endocrine Society</title><description>Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but the effect of basal serum triglycerides levels on this reversal is unknown. This study aimed to assess the association between preoperative triglycerides levels and pre- and type 2 diabetes mellitus remission in obese patients one year after bariatric surgery.
Methods: A retrospective study was conducted among 1959 obese patients who underwent bariatric surgery in our entre. Data on socio-demographic and clinical characteristics were used. Pre-diabetes and type 2 diabetes mellitus remission was defined as normal glycaemic measures at least one year’s duration without pharmacological therapy. Logistic regression models, crude and adjusted for sex, age, preoperative serum triglycerides levels and type of bariatric surgery, were used.
Results: The median of preoperative serum triglycerides level was 121.00 (SD=75.00) mg/dL, and 34.7% and 30.0% of patients presented pre- and type 2 diabetes mellitus, respectively, at baseline. Preoperative serum triglycerides levels were higher in type 2 diabetes mellitus patients (139.00 vs. 106.00 mg/dL, in normal glycaemic patients; p<0.001) and showed to be significantly correlated with fasting glycaemia, glycated
haemoglobin, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. One year after bariatric surgery, 62.5% of patients with pre- or type 2 diabetes at baseline showed remission. Preoperative serum triglycerides levels were negatively associated with this remission (OR: 0.997; 95%CI=0.995–0.998), independently of, sex, age and type of bariatric surgery. Conclusions: One year after bariatric surgery, 62.5% of patients showed pre- or type 2 diabetes mellitus remission, being the preoperative serum triglycerides levels an important clinical parameter for remission.
Keywords: triglycerides, diabetes, remission, obesity, bariatric surgery</description><subject>Adipose Tissue, Appetite, and Obesity</subject><issn>2472-1972</issn><issn>2472-1972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkd1qwkAQhZfSQsX6Ar3aF4juX5NsLwqt_QWLYuP1stnM6kpMZDcGQl--EaW0DMwMDOcchg-hW0rGlFEy2UJVhHqStzonIh2TJL5AAyYSFlGZsMs_-zUahbAlhFDJhRRigL6zbg-Y4Wenc2gg4E8oS9ccAl7CzoXg6gq7Cs9zCIAXunFQNQGvqgI8ftLe6cY7g78Ofg2-u8fZBvCyLgHXFi881HvwvaYFnHm3LjsD3hV9yAxaKMMNurK6DDA6zyFavb5k0_doNn_7mD7OIkMFi6MkZdZaZoRMjqWpsVTTmEnb94Iyzbjk1iTABSPiDrgkPAYpY5pYXeSMD9HDyXd_yHdQmP4Fr0u1926nfadq7dT_S-U2al23KiWpTGLeG7CTgfF1CB7sr5YSdUSgTgjUGYHqEfAfoxF_ag</recordid><startdate>20210503</startdate><enddate>20210503</enddate><creator>Gonçalves, Vanessa Guerreiro</creator><creator>Maia, Isabel</creator><creator>Mendonça, Fernando</creator><creator>Silva, Maria Manuel</creator><creator>Neves, João Sérgio</creator><creator>Pedro, Jorge Pires</creator><creator>Salazar, Cristina Daniela</creator><creator>Ferreira, Maria João Silva</creator><creator>Costa, Cláudia Fernandes</creator><creator>Canha, Marta Borges</creator><creator>Lau, Eva</creator><creator>Freitas, Paula</creator><creator>Carvalho, Davide M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210503</creationdate><title>Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels</title><author>Gonçalves, Vanessa Guerreiro ; Maia, Isabel ; Mendonça, Fernando ; Silva, Maria Manuel ; Neves, João Sérgio ; Pedro, Jorge Pires ; Salazar, Cristina Daniela ; Ferreira, Maria João Silva ; Costa, Cláudia Fernandes ; Canha, Marta Borges ; Lau, Eva ; Freitas, Paula ; Carvalho, Davide M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1426-782fff2c4979797a1cf1a1629fa16d12a2393fc7e342045e39036e99617fadb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose Tissue, Appetite, and Obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonçalves, Vanessa Guerreiro</creatorcontrib><creatorcontrib>Maia, Isabel</creatorcontrib><creatorcontrib>Mendonça, Fernando</creatorcontrib><creatorcontrib>Silva, Maria Manuel</creatorcontrib><creatorcontrib>Neves, João Sérgio</creatorcontrib><creatorcontrib>Pedro, Jorge Pires</creatorcontrib><creatorcontrib>Salazar, Cristina Daniela</creatorcontrib><creatorcontrib>Ferreira, Maria João Silva</creatorcontrib><creatorcontrib>Costa, Cláudia Fernandes</creatorcontrib><creatorcontrib>Canha, Marta Borges</creatorcontrib><creatorcontrib>Lau, Eva</creatorcontrib><creatorcontrib>Freitas, Paula</creatorcontrib><creatorcontrib>Carvalho, Davide M</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Endocrine Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonçalves, Vanessa Guerreiro</au><au>Maia, Isabel</au><au>Mendonça, Fernando</au><au>Silva, Maria Manuel</au><au>Neves, João Sérgio</au><au>Pedro, Jorge Pires</au><au>Salazar, Cristina Daniela</au><au>Ferreira, Maria João Silva</au><au>Costa, Cláudia Fernandes</au><au>Canha, Marta Borges</au><au>Lau, Eva</au><au>Freitas, Paula</au><au>Carvalho, Davide M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels</atitle><jtitle>Journal of the Endocrine Society</jtitle><date>2021-05-03</date><risdate>2021</risdate><volume>5</volume><issue>Supplement_1</issue><spage>A39</spage><epage>A39</epage><pages>A39-A39</pages><issn>2472-1972</issn><eissn>2472-1972</eissn><abstract>Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but the effect of basal serum triglycerides levels on this reversal is unknown. This study aimed to assess the association between preoperative triglycerides levels and pre- and type 2 diabetes mellitus remission in obese patients one year after bariatric surgery.
Methods: A retrospective study was conducted among 1959 obese patients who underwent bariatric surgery in our entre. Data on socio-demographic and clinical characteristics were used. Pre-diabetes and type 2 diabetes mellitus remission was defined as normal glycaemic measures at least one year’s duration without pharmacological therapy. Logistic regression models, crude and adjusted for sex, age, preoperative serum triglycerides levels and type of bariatric surgery, were used.
Results: The median of preoperative serum triglycerides level was 121.00 (SD=75.00) mg/dL, and 34.7% and 30.0% of patients presented pre- and type 2 diabetes mellitus, respectively, at baseline. Preoperative serum triglycerides levels were higher in type 2 diabetes mellitus patients (139.00 vs. 106.00 mg/dL, in normal glycaemic patients; p<0.001) and showed to be significantly correlated with fasting glycaemia, glycated
haemoglobin, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. One year after bariatric surgery, 62.5% of patients with pre- or type 2 diabetes at baseline showed remission. Preoperative serum triglycerides levels were negatively associated with this remission (OR: 0.997; 95%CI=0.995–0.998), independently of, sex, age and type of bariatric surgery. Conclusions: One year after bariatric surgery, 62.5% of patients showed pre- or type 2 diabetes mellitus remission, being the preoperative serum triglycerides levels an important clinical parameter for remission.
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Adipose Tissue, Appetite, and Obesity |
| title | Type 2 Diabetes Mellitus Remission in Obese Patients Under Bariatric Surgery: The Role of Preoperative Triglycerides Levels |
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