Investigating the Role of Cholesterol and Lipid Trafficking in Mitotane Resistance in Adrenocortical Carcinoma

Introduction: Adrenocortical Carcinoma (ACC) is a rare aggressive cancer which carries a poor prognosis. Adjuvant mitotane improves survival but is limited by poor response rates and resistance following tumour recurrence. Mitotane’s efficacy has been attributed to intracellular accumulation of toxi...

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Veröffentlicht in:	Journal of the Endocrine Society 2021-05, Vol.5 (Supplement_1), p.A70-A70
Hauptverfasser:	Warde, Kate, Lim, Yi-Jan, Beuschlein, Felix, Hantel, Constanze, Dennedy, Michael Conall
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal
Online-Zugang:	Volltext
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