VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene‐driven non‐small‐cell lung cancers

Molecular agents targeting the epidermal growth factor receptor (EGFR)‐, anaplastic lymphoma kinase (ALK)‐ or c‐ros oncogene 1 (ROS1) alterations have revolutionized the treatment of oncogene‐driven non‐small‐cell lung cancer (NSCLC). However, the emergence of acquired resistance remains a significa...

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Veröffentlicht in:	Cancer science 2021-05, Vol.112 (5), p.1853-1864
Hauptverfasser:	Watanabe, Hiromi, Ichihara, Eiki, Kayatani, Hiroe, Makimoto, Go, Ninomiya, Kiichiro, Nishii, Kazuya, Higo, Hisao, Ando, Chihiro, Okawa, Sachi, Nakasuka, Takamasa, Kano, Hirohisa, Hara, Naofumi, Hirabae, Atsuko, Kato, Yuka, Ninomiya, Takashi, Kubo, Toshio, Rai, Kammei, Ohashi, Kadoaki, Hotta, Katsuyuki, Tabata, Masahiro, Maeda, Yoshinobu, Kiura, Katsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acrylamides - therapeutic use Anaplastic Lymphoma Kinase - genetics Angiogenesis inhibitors Angiogenesis Inhibitors - therapeutic use Aniline Compounds - therapeutic use Animal models Animals Antibodies Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Blood vessels Cancer therapies Carbazoles - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Combined Modality Therapy - methods Crizotinib - therapeutic use Drug Synergism Epidermal growth factor Epidermal growth factor receptors Erlotinib Hydrochloride - therapeutic use Female Genes, erbB-1 Heterografts Humans Kinases Laboratory animals Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Mice Mice, Inbred BALB C Mice, Nude Molecular Targeted Therapy - methods Mutation Neovascularization, Pathologic - prevention & control Non-small cell lung carcinoma Oncogenes Original Piperidines - therapeutic use Platelet Endothelial Cell Adhesion Molecule-1 - analysis Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics R&D Ramucirumab Random Allocation Reagents Research & development Signal Transduction - drug effects Statistical analysis Tumors Tyrosine kinase inhibitors Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors Xenografts
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