VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy

V-domain Ig suppressor of T cell activation (VISTA) is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. During inflammatory challenges, VISTA activity reprograms macrophages towards reduced production of proinflammatory c...

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Veröffentlicht in:	Trends in immunology 2021-03, Vol.42 (3), p.209-227
Hauptverfasser:	Yuan, Long, Tatineni, Jahnavi, Mahoney, Kathleen M., Freeman, Gordon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic tumor microenvironment Antibodies Antitumor activity B7 antigen Binding Cancer Cancer immunotherapy Cell activation Chemokines Cloning Drug development Gastric cancer Glycoproteins Immunoglobulins Immunosuppression Immunotherapy Infections Inflammation Interleukins Kinases Ligands Lymphocytes Lymphocytes T Macrophages P-selectin P-selectin glycoprotein ligand 1 pH effects Phosphorylation Proteins PSGL-1 T cell receptors Tumor microenvironment Tumors Viral infections VISTA VSIG3
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