Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling

Objectives Previously, our investigations demonstrated robust pro‐angiogenic potentials of extracellular vesicles secreted by periodontitis‐compromised dental pulp stem cells (P‐EVs) when compared to those from healthy DPSCs (H‐EVs), but the underlying mechanism remains unknown. Materials and method...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell proliferation 2021-05, Vol.54 (5), p.e13026-n/a
Hauptverfasser:	Zhou, Huan, Li, Xuan, Wu, Rui‐Xin, He, Xiao‐Tao, An, Ying, Xu, Xin‐Yue, Sun, Hai‐Hua, Wu, Li‐An, Chen, Fa‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antagomirs - metabolism Binding sites Cell growth Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cholecystokinin Dental materials Dental pulp Dental Pulp - cytology Dental Pulp - metabolism dental pulp stem cells DNA microarrays Endothelial cells Extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Gene expression Genes Growth factors Gum disease Hedgehog protein Hedgehog Proteins - metabolism Human Umbilical Vein Endothelial Cells Humans Hybridization MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miRNA Neovascularization, Physiologic Original Periodontitis Periodontitis - metabolism Periodontitis - pathology Plasmids Pyridines - pharmacology Pyrimidines - pharmacology Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleic acid RNA RNA Interference RNA, Small Interfering - metabolism RNA-mediated interference Signal Transduction Signaling Stem cells Stem Cells - cytology Stem Cells - metabolism Sufu Target recognition Teeth Tissue engineering Transfection Vascular endothelial growth factor Vesicles Wound healing Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!