AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells

Aberrantly processed or mutant proteins misfold and assemble into a variety of soluble oligomers and insoluble aggregates, a process that is associated with an increasing number of diseases that are not curable or manageable. Herein, we present a chemical toolbox, AggFluor, that allows for live cell...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2020-10, Vol.142 (41), p.17515-17523
Hauptverfasser:	Wolstenholme, Charles H, Hu, Hang, Ye, Songtao, Funk, Brian E, Jain, Divya, Hsiung, Chia-Heng, Ning, Gang, Liu, Yu, Li, Xiaosong, Zhang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluorescent Dyes - chemistry Green Fluorescent Proteins - chemistry HEK293 Cells Humans Optical Imaging Protein Aggregates Protein Conformation Protein Folding Solvents - chemistry Spectrometry, Fluorescence Viscosity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!