Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression predicts clinical outcomes for sporadic breast ca...

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Veröffentlicht in:	Molecular and cellular biology 2021-04, Vol.41 (4)
Hauptverfasser:	Lu, Xing, Redon, Christophe E., Tang, Wei, Parvathaneni, Swetha, Bokhari, Bayan, Debnath, Subrata, Li, Xiao Ling, Muys, Bruna R., Song, Young, Pongor, Lorinc S., Sheikh, Omar, Green, Andrew R., Madhusudan, Srinivasan, Lal, Ashish, Ambs, Stefan, Khan, Javed, Aladjem, Mirit I., Sharma, Sudha
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor DNA helicase estrogen receptor Estrogen Receptor alpha - metabolism Estrogens - metabolism FOXA1 Gene Expression Regulation, Neoplastic - genetics Genetic Predisposition to Disease - genetics Hepatocyte Nuclear Factor 3-alpha - genetics Humans RecQ Helicases - metabolism RECQ1 Research Article transcriptional regulation
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