Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Background and Purpose. Mild cognitive impairment (MCI) is a common condition, which threatens the quality of life of older adults. Tai Chi (TC) is growing in popularity among patients with MCI. This study is aimed at evaluating the effectiveness and safety of TC in older adults with MCI. Design. Ra...
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| Veröffentlicht in: | BioMed research international 2021, Vol.2021 (1), p.5530149-5530149 |
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| creator | Lin, Run Cui, Shaoyang Yang, Juan Yang, Huijun Feng, Zitong Wahner-Roedler, Dietlind L. Zhou, Xuan Salinas, Manisha Mallory, Molly J. Do, Alexander Bublitz, Sara E. Chon, Tony Y. Tang, Chunzhi Bauer, Brent A. Xu, Mingzhu |
| description | Background and Purpose. Mild cognitive impairment (MCI) is a common condition, which threatens the quality of life of older adults. Tai Chi (TC) is growing in popularity among patients with MCI. This study is aimed at evaluating the effectiveness and safety of TC in older adults with MCI. Design. Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score. Meta-analysis of RCTs on TC in the treatment of MCI was performed with RevMan Version 5.4.1. Results. Seven RCTs with 1265 participants were included. For most RCTs, the overall reporting of methodological quality was high. Results of the meta-analysis indicate that TC improved MCI patients’ cognitive function significantly, including overall cognitive function (MD=−2.24, 95% CI -3.51 to -0.97, P=0.0005), memory and learning (SMD=0.83, 95% CI 0.22 to 1.45, P=0.008), visuospatial ability (MD=3.15, 95% CI 0.74 to 5.56, P=0.01), executive functions (MD=0.32, 95% CI 0.03 to 0.61, P=0.03), and physical activity (MD=18.78, 95% CI 10.80 to 26.76, P |
| doi_str_mv | 10.1155/2021/5530149 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8087475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A684360161</galeid><sourcerecordid>A684360161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-6c4205261e2cafdca51f50ec1d66220ef7f711668dee35ba14ec5bbd93bf9f2e3</originalsourceid><addsrcrecordid>eNp9kk1vEzEQhi0EolXojTOyxAUJlvp7dzkgRVELlVqBSjhbXu84cbW7DutNonDmh9fbhPBxqC8zmnn02jN-EXpJyXtKpTxnhNFzKTmhonyCThmnIlNU0KfHnPMTdBbjHUmnoIqU6jk64bzMc0r4Kfp14RzYIeLg8Nx4PFt6HDr81QweulTe-mGJb3xT41lYdH7wG8BX7cr4vk39D3iKv-3iAG3iLb6FjYctNl2Nb2AwmelMs4v-Qfw2VUPrf8Ko1A19aJqUzntvmvgCPXMpwNkhTtD3y4v57HN2_eXT1Wx6nVlJxJApKxiRTFFg1rjaGkmdJGBprRRjBFzuckqVKmoALitDBVhZVXXJK1c6BnyCPu51V-uqhdqmCXrT6FXvW9PvdDBe_9vp_FIvwkYXpMhFLpPAm4NAH36sIQ669dFC05gOwjpqNr5OEiJH9PV_6F1Y92khDxRRuRCE_6EWpgHtOxfSvXYU1VNVqpKyXInHqUJwRWj66Al6t6dsH2LswR0Ho0SPbtGjW_TBLQl_9fcyjvBvbyTg7R5Y-q42W_-43D1WT8Xd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520674403</pqid></control><display><type>article</type><title>Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Lin, Run ; Cui, Shaoyang ; Yang, Juan ; Yang, Huijun ; Feng, Zitong ; Wahner-Roedler, Dietlind L. ; Zhou, Xuan ; Salinas, Manisha ; Mallory, Molly J. ; Do, Alexander ; Bublitz, Sara E. ; Chon, Tony Y. ; Tang, Chunzhi ; Bauer, Brent A. ; Xu, Mingzhu</creator><contributor>Tang, Min</contributor><creatorcontrib>Lin, Run ; Cui, Shaoyang ; Yang, Juan ; Yang, Huijun ; Feng, Zitong ; Wahner-Roedler, Dietlind L. ; Zhou, Xuan ; Salinas, Manisha ; Mallory, Molly J. ; Do, Alexander ; Bublitz, Sara E. ; Chon, Tony Y. ; Tang, Chunzhi ; Bauer, Brent A. ; Xu, Mingzhu ; Tang, Min</creatorcontrib><description>Background and Purpose. Mild cognitive impairment (MCI) is a common condition, which threatens the quality of life of older adults. Tai Chi (TC) is growing in popularity among patients with MCI. This study is aimed at evaluating the effectiveness and safety of TC in older adults with MCI. Design. Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score. Meta-analysis of RCTs on TC in the treatment of MCI was performed with RevMan Version 5.4.1. Results. Seven RCTs with 1265 participants were included. For most RCTs, the overall reporting of methodological quality was high. Results of the meta-analysis indicate that TC improved MCI patients’ cognitive function significantly, including overall cognitive function (MD=−2.24, 95% CI -3.51 to -0.97, P=0.0005), memory and learning (SMD=0.83, 95% CI 0.22 to 1.45, P=0.008), visuospatial ability (MD=3.15, 95% CI 0.74 to 5.56, P=0.01), executive functions (MD=0.32, 95% CI 0.03 to 0.61, P=0.03), and physical activity (MD=18.78, 95% CI 10.80 to 26.76, P<0.00001). However, no significant benefit was found for TC on psychological activity (MD=0.17, 95% CI -0.62 to 0.96, P=0.36) and biomarker improvement. Conclusion. The meta-analysis confirmed the clinical therapeutic effect of TC for MCI. More rigorous and long-term follow-up RCTs should be conducted in the future.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/5530149</identifier><identifier>PMID: 33977103</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Adults ; Age ; Aged ; Aged, 80 and over ; Bias ; Biomarkers ; Care and treatment ; Clinical trials ; Cognition & reasoning ; Cognition - physiology ; Cognition disorders ; Cognition disorders in old age ; Cognitive ability ; Cognitive Dysfunction - therapy ; Dementia ; Evaluation ; Executive function ; Exercise ; Exercise - physiology ; Exercise therapy ; Female ; Health aspects ; Health education ; Humans ; Impairment ; Intervention ; Male ; Martial arts ; Memory ; Meta-analysis ; Middle Aged ; Older people ; Patients ; Physical activity ; Physical fitness ; Psychological aspects ; Quality assessment ; Quality of life ; Randomized Controlled Trials as Topic ; Review ; Statistical analysis ; Systematic review ; T'ai chi ch'uan ; Tai Ji ; Testing ; Therapeutics, Experimental</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.5530149-5530149</ispartof><rights>Copyright © 2021 Run Lin et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Run Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Run Lin et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-6c4205261e2cafdca51f50ec1d66220ef7f711668dee35ba14ec5bbd93bf9f2e3</citedby><cites>FETCH-LOGICAL-c504t-6c4205261e2cafdca51f50ec1d66220ef7f711668dee35ba14ec5bbd93bf9f2e3</cites><orcidid>0000-0002-0850-679X ; 0000-0002-6812-083X ; 0000-0002-6345-6385 ; 0000-0003-3453-6906 ; 0000-0003-3858-6476 ; 0000-0002-3646-4179 ; 0000-0003-3127-578X ; 0000-0001-8329-5737 ; 0000-0002-2375-0731 ; 0000-0001-6723-7465 ; 0000-0002-5974-0578 ; 0000-0003-0467-6086 ; 0000-0002-5501-4579 ; 0000-0003-0446-2985 ; 0000-0001-7770-2535</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087475/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087475/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33977103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tang, Min</contributor><creatorcontrib>Lin, Run</creatorcontrib><creatorcontrib>Cui, Shaoyang</creatorcontrib><creatorcontrib>Yang, Juan</creatorcontrib><creatorcontrib>Yang, Huijun</creatorcontrib><creatorcontrib>Feng, Zitong</creatorcontrib><creatorcontrib>Wahner-Roedler, Dietlind L.</creatorcontrib><creatorcontrib>Zhou, Xuan</creatorcontrib><creatorcontrib>Salinas, Manisha</creatorcontrib><creatorcontrib>Mallory, Molly J.</creatorcontrib><creatorcontrib>Do, Alexander</creatorcontrib><creatorcontrib>Bublitz, Sara E.</creatorcontrib><creatorcontrib>Chon, Tony Y.</creatorcontrib><creatorcontrib>Tang, Chunzhi</creatorcontrib><creatorcontrib>Bauer, Brent A.</creatorcontrib><creatorcontrib>Xu, Mingzhu</creatorcontrib><title>Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background and Purpose. Mild cognitive impairment (MCI) is a common condition, which threatens the quality of life of older adults. Tai Chi (TC) is growing in popularity among patients with MCI. This study is aimed at evaluating the effectiveness and safety of TC in older adults with MCI. Design. Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score. Meta-analysis of RCTs on TC in the treatment of MCI was performed with RevMan Version 5.4.1. Results. Seven RCTs with 1265 participants were included. For most RCTs, the overall reporting of methodological quality was high. Results of the meta-analysis indicate that TC improved MCI patients’ cognitive function significantly, including overall cognitive function (MD=−2.24, 95% CI -3.51 to -0.97, P=0.0005), memory and learning (SMD=0.83, 95% CI 0.22 to 1.45, P=0.008), visuospatial ability (MD=3.15, 95% CI 0.74 to 5.56, P=0.01), executive functions (MD=0.32, 95% CI 0.03 to 0.61, P=0.03), and physical activity (MD=18.78, 95% CI 10.80 to 26.76, P<0.00001). However, no significant benefit was found for TC on psychological activity (MD=0.17, 95% CI -0.62 to 0.96, P=0.36) and biomarker improvement. Conclusion. The meta-analysis confirmed the clinical therapeutic effect of TC for MCI. More rigorous and long-term follow-up RCTs should be conducted in the future.</description><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bias</subject><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognition disorders</subject><subject>Cognition disorders in old age</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Dementia</subject><subject>Evaluation</subject><subject>Executive function</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise therapy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health education</subject><subject>Humans</subject><subject>Impairment</subject><subject>Intervention</subject><subject>Male</subject><subject>Martial arts</subject><subject>Memory</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Psychological aspects</subject><subject>Quality assessment</subject><subject>Quality of life</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Review</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>T'ai chi ch'uan</subject><subject>Tai Ji</subject><subject>Testing</subject><subject>Therapeutics, 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of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials</title><author>Lin, Run ; Cui, Shaoyang ; Yang, Juan ; Yang, Huijun ; Feng, Zitong ; Wahner-Roedler, Dietlind L. ; Zhou, Xuan ; Salinas, Manisha ; Mallory, Molly J. ; Do, Alexander ; Bublitz, Sara E. ; Chon, Tony Y. ; Tang, Chunzhi ; Bauer, Brent A. ; Xu, Mingzhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-6c4205261e2cafdca51f50ec1d66220ef7f711668dee35ba14ec5bbd93bf9f2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bias</topic><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Cognition disorders</topic><topic>Cognition disorders in old age</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Dementia</topic><topic>Evaluation</topic><topic>Executive function</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise therapy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health education</topic><topic>Humans</topic><topic>Impairment</topic><topic>Intervention</topic><topic>Male</topic><topic>Martial arts</topic><topic>Memory</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Patients</topic><topic>Physical activity</topic><topic>Physical fitness</topic><topic>Psychological aspects</topic><topic>Quality assessment</topic><topic>Quality of life</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Review</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><topic>T'ai chi ch'uan</topic><topic>Tai Ji</topic><topic>Testing</topic><topic>Therapeutics, Experimental</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Run</creatorcontrib><creatorcontrib>Cui, Shaoyang</creatorcontrib><creatorcontrib>Yang, Juan</creatorcontrib><creatorcontrib>Yang, Huijun</creatorcontrib><creatorcontrib>Feng, Zitong</creatorcontrib><creatorcontrib>Wahner-Roedler, Dietlind L.</creatorcontrib><creatorcontrib>Zhou, Xuan</creatorcontrib><creatorcontrib>Salinas, Manisha</creatorcontrib><creatorcontrib>Mallory, Molly J.</creatorcontrib><creatorcontrib>Do, Alexander</creatorcontrib><creatorcontrib>Bublitz, Sara E.</creatorcontrib><creatorcontrib>Chon, Tony Y.</creatorcontrib><creatorcontrib>Tang, Chunzhi</creatorcontrib><creatorcontrib>Bauer, Brent A.</creatorcontrib><creatorcontrib>Xu, Mingzhu</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open 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Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Run</au><au>Cui, Shaoyang</au><au>Yang, Juan</au><au>Yang, Huijun</au><au>Feng, Zitong</au><au>Wahner-Roedler, Dietlind L.</au><au>Zhou, Xuan</au><au>Salinas, Manisha</au><au>Mallory, Molly J.</au><au>Do, Alexander</au><au>Bublitz, Sara E.</au><au>Chon, Tony Y.</au><au>Tang, Chunzhi</au><au>Bauer, Brent A.</au><au>Xu, Mingzhu</au><au>Tang, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>5530149</spage><epage>5530149</epage><pages>5530149-5530149</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background and Purpose. Mild cognitive impairment (MCI) is a common condition, which threatens the quality of life of older adults. Tai Chi (TC) is growing in popularity among patients with MCI. This study is aimed at evaluating the effectiveness and safety of TC in older adults with MCI. Design. Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score. Meta-analysis of RCTs on TC in the treatment of MCI was performed with RevMan Version 5.4.1. Results. Seven RCTs with 1265 participants were included. For most RCTs, the overall reporting of methodological quality was high. Results of the meta-analysis indicate that TC improved MCI patients’ cognitive function significantly, including overall cognitive function (MD=−2.24, 95% CI -3.51 to -0.97, P=0.0005), memory and learning (SMD=0.83, 95% CI 0.22 to 1.45, P=0.008), visuospatial ability (MD=3.15, 95% CI 0.74 to 5.56, P=0.01), executive functions (MD=0.32, 95% CI 0.03 to 0.61, P=0.03), and physical activity (MD=18.78, 95% CI 10.80 to 26.76, P<0.00001). However, no significant benefit was found for TC on psychological activity (MD=0.17, 95% CI -0.62 to 0.96, P=0.36) and biomarker improvement. Conclusion. The meta-analysis confirmed the clinical therapeutic effect of TC for MCI. More rigorous and long-term follow-up RCTs should be conducted in the future.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33977103</pmid><doi>10.1155/2021/5530149</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0850-679X</orcidid><orcidid>https://orcid.org/0000-0002-6812-083X</orcidid><orcidid>https://orcid.org/0000-0002-6345-6385</orcidid><orcidid>https://orcid.org/0000-0003-3453-6906</orcidid><orcidid>https://orcid.org/0000-0003-3858-6476</orcidid><orcidid>https://orcid.org/0000-0002-3646-4179</orcidid><orcidid>https://orcid.org/0000-0003-3127-578X</orcidid><orcidid>https://orcid.org/0000-0001-8329-5737</orcidid><orcidid>https://orcid.org/0000-0002-2375-0731</orcidid><orcidid>https://orcid.org/0000-0001-6723-7465</orcidid><orcidid>https://orcid.org/0000-0002-5974-0578</orcidid><orcidid>https://orcid.org/0000-0003-0467-6086</orcidid><orcidid>https://orcid.org/0000-0002-5501-4579</orcidid><orcidid>https://orcid.org/0000-0003-0446-2985</orcidid><orcidid>https://orcid.org/0000-0001-7770-2535</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2021, Vol.2021 (1), p.5530149-5530149 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8087475 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Adults Age Aged Aged, 80 and over Bias Biomarkers Care and treatment Clinical trials Cognition & reasoning Cognition - physiology Cognition disorders Cognition disorders in old age Cognitive ability Cognitive Dysfunction - therapy Dementia Evaluation Executive function Exercise Exercise - physiology Exercise therapy Female Health aspects Health education Humans Impairment Intervention Male Martial arts Memory Meta-analysis Middle Aged Older people Patients Physical activity Physical fitness Psychological aspects Quality assessment Quality of life Randomized Controlled Trials as Topic Review Statistical analysis Systematic review T'ai chi ch'uan Tai Ji Testing Therapeutics, Experimental |
| title | Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials |
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