GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

Abstract The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. Epigenetic clocks measure changes in DNA methylation levels at specific CpG sites that are hi...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-05, Vol.76 (5), p.741-749
Hauptverfasser:	McCrory, Cathal, Fiorito, Giovanni, Hernandez, Belinda, Polidoro, Silvia, O’Halloran, Aisling M, Hever, Ann, Ni Cheallaigh, Cliona, Lu, Ake T, Horvath, Steve, Vineis, Paolo, Kenny, Rose Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Cognitive ability CpG islands Deoxyribonucleic acid DNA DNA Methylation Editor's Choice Epigenesis, Genetic Epigenetics Female Frailty Genetic Markers Hand Strength Humans Longitudinal Studies Male Middle Aged Mortality Neuropsychological Tests Older people Phenotype Phenotypes Polypharmacy Precision medicine Studies THE JOURNAL OF GERONTOLOGY: Biological Sciences Walking Speed
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