Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection
In children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virological characteristics and correlation with disease severity have not been extensively studied. The primary objective in this study is to determine the correlation between SARS-CoV-2 viral load (VL) in infe...
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| Veröffentlicht in: | Pediatrics (Evanston) 2021-05, Vol.147 (5), p.1 |
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| creator | Pinninti, Swetha G Pati, Sunil Poole, Claudette Latting, Misty Seleme, Maria C Yarbrough, April Arora, Nitin Britt, William J Boppana, Suresh |
| description | In children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virological characteristics and correlation with disease severity have not been extensively studied. The primary objective in this study is to determine the correlation between SARS-CoV-2 viral load (VL) in infected children with age, disease severity, and underlying comorbidities.
Children 1 comorbidity were the most at risk for severe disease. VL in children with symptomatic infection was significantly higher than in children with asymptomatic infection (3.0 × 10
vs 7.2 × 10
copies per mL;
= .001). VL in the respiratory tract was significantly higher in children 1 comorbid condition experienced severe disease. SARS-CoV-2 VL in the respiratory tract is significantly higher in children with symptomatic disease and children |
| doi_str_mv | 10.1542/peds.2020-037812 |
| format | Article |
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Children <21 years, screened for SARS-CoV-2 at the time of hospitalization, who tested positive by polymerase chain reaction were included in this study. VL at different sites was determined and compared between groups.
Of the 102 children included in this study, 44% of the cohort had asymptomatic infection, and children with >1 comorbidity were the most at risk for severe disease. VL in children with symptomatic infection was significantly higher than in children with asymptomatic infection (3.0 × 10
vs 7.2 × 10
copies per mL;
= .001). VL in the respiratory tract was significantly higher in children <1 year, compared with older children (3.3 × 10
vs 1.3 × 10
copies per mL respectively;
< .0001), despite most infants presenting with milder illness. Besides the respiratory tract, SARS-CoV-2 RNA was also detectable in samples from the gastrointestinal tract (saliva and rectum) and blood. In 13 children for whom data on duration of polymerase chain reaction positivity was available, 12 of 13 tested positive 2 weeks after initial diagnosis, and 6 of 13 continued to test positive 4 weeks after initial diagnosis.
In hospitalized children with SARS-CoV-2, those with >1 comorbid condition experienced severe disease. SARS-CoV-2 VL in the respiratory tract is significantly higher in children with symptomatic disease and children <1 year of age.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2020-037812</identifier><identifier>PMID: 33622794</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adolescent ; Asymptomatic ; Asymptomatic infection ; Asymptomatic Infections ; Child ; Child, Preschool ; Children ; Comorbidity ; Coronaviruses ; COVID-19 - diagnosis ; COVID-19 - virology ; COVID-19 Nucleic Acid Testing ; Diagnosis ; Gastrointestinal tract ; Hospitalization ; Humans ; Infant ; Infants ; Infections ; Nasopharynx - virology ; Nose - virology ; Pediatrics ; Polymerase chain reaction ; Rectum ; Rectum - virology ; Respiratory tract ; Saliva ; Salvia - virology ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Time Factors ; Viral Load ; Virus Shedding ; Young Adult</subject><ispartof>Pediatrics (Evanston), 2021-05, Vol.147 (5), p.1</ispartof><rights>Copyright © 2021 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics May 1, 2021</rights><rights>Copyright © 2021 by the American Academy of Pediatrics 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-1d2924a00a03f79fa5cd64e50675224af498a847681b14e2208962e11cf6084b3</citedby><cites>FETCH-LOGICAL-c424t-1d2924a00a03f79fa5cd64e50675224af498a847681b14e2208962e11cf6084b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33622794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinninti, Swetha G</creatorcontrib><creatorcontrib>Pati, Sunil</creatorcontrib><creatorcontrib>Poole, Claudette</creatorcontrib><creatorcontrib>Latting, Misty</creatorcontrib><creatorcontrib>Seleme, Maria C</creatorcontrib><creatorcontrib>Yarbrough, April</creatorcontrib><creatorcontrib>Arora, Nitin</creatorcontrib><creatorcontrib>Britt, William J</creatorcontrib><creatorcontrib>Boppana, Suresh</creatorcontrib><title>Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>In children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virological characteristics and correlation with disease severity have not been extensively studied. The primary objective in this study is to determine the correlation between SARS-CoV-2 viral load (VL) in infected children with age, disease severity, and underlying comorbidities.
Children <21 years, screened for SARS-CoV-2 at the time of hospitalization, who tested positive by polymerase chain reaction were included in this study. VL at different sites was determined and compared between groups.
Of the 102 children included in this study, 44% of the cohort had asymptomatic infection, and children with >1 comorbidity were the most at risk for severe disease. VL in children with symptomatic infection was significantly higher than in children with asymptomatic infection (3.0 × 10
vs 7.2 × 10
copies per mL;
= .001). VL in the respiratory tract was significantly higher in children <1 year, compared with older children (3.3 × 10
vs 1.3 × 10
copies per mL respectively;
< .0001), despite most infants presenting with milder illness. Besides the respiratory tract, SARS-CoV-2 RNA was also detectable in samples from the gastrointestinal tract (saliva and rectum) and blood. In 13 children for whom data on duration of polymerase chain reaction positivity was available, 12 of 13 tested positive 2 weeks after initial diagnosis, and 6 of 13 continued to test positive 4 weeks after initial diagnosis.
In hospitalized children with SARS-CoV-2, those with >1 comorbid condition experienced severe disease. SARS-CoV-2 VL in the respiratory tract is significantly higher in children with symptomatic disease and children <1 year of age.</description><subject>Adolescent</subject><subject>Asymptomatic</subject><subject>Asymptomatic infection</subject><subject>Asymptomatic Infections</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Comorbidity</subject><subject>Coronaviruses</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - virology</subject><subject>COVID-19 Nucleic Acid Testing</subject><subject>Diagnosis</subject><subject>Gastrointestinal tract</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Infections</subject><subject>Nasopharynx - virology</subject><subject>Nose - virology</subject><subject>Pediatrics</subject><subject>Polymerase chain reaction</subject><subject>Rectum</subject><subject>Rectum - virology</subject><subject>Respiratory tract</subject><subject>Saliva</subject><subject>Salvia - virology</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Viral Load</subject><subject>Virus Shedding</subject><subject>Young Adult</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLAzEURoMoWh97VzLgxs3ozZ0kk9kIUnyBKPioy5BmMjYyndRkKuivN6VV1FUW37kfufcQsk_hmHKGJzNbx2MEhByKUlJcIwMKlcwZlnydDAAKmjMAvkW2Y3wFAMZL3CRbRSEQy4oNyO3IBd_6F2d0mw0nOmjT2-Bi70zMfJNd-ThzvW7dp61T7to62C57dv0kezi7f8iHfpRjdt011vTOd7tko9FttHurd4c8XZw_Dq_ym7vL6-HZTW4Ysj6nNVbINICGoimrRnNTC2Y5iJJjChpWSS1ZKSQdU2YRQVYCLaWmESDZuNghp8ve2Xw8tbWxXR90q2bBTXX4UF479Tfp3ES9-HclQYp0llRwtCoI_m1uY6-mLhrbtrqzfh4VsqpInCirhB7-Q1_9PHRpPYUcGQPBpUgULCkTfIzBNj-foaAWstRCllrIUktZaeTg9xI_A992ii-KJY8S</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Pinninti, Swetha G</creator><creator>Pati, Sunil</creator><creator>Poole, Claudette</creator><creator>Latting, Misty</creator><creator>Seleme, Maria C</creator><creator>Yarbrough, April</creator><creator>Arora, Nitin</creator><creator>Britt, William J</creator><creator>Boppana, Suresh</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210501</creationdate><title>Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection</title><author>Pinninti, Swetha G ; Pati, Sunil ; Poole, Claudette ; Latting, Misty ; Seleme, Maria C ; Yarbrough, April ; Arora, Nitin ; Britt, William J ; Boppana, Suresh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-1d2924a00a03f79fa5cd64e50675224af498a847681b14e2208962e11cf6084b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Asymptomatic</topic><topic>Asymptomatic infection</topic><topic>Asymptomatic Infections</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Comorbidity</topic><topic>Coronaviruses</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - virology</topic><topic>COVID-19 Nucleic Acid Testing</topic><topic>Diagnosis</topic><topic>Gastrointestinal tract</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Infections</topic><topic>Nasopharynx - virology</topic><topic>Nose - virology</topic><topic>Pediatrics</topic><topic>Polymerase chain reaction</topic><topic>Rectum</topic><topic>Rectum - virology</topic><topic>Respiratory tract</topic><topic>Saliva</topic><topic>Salvia - virology</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Viral Load</topic><topic>Virus Shedding</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinninti, Swetha G</creatorcontrib><creatorcontrib>Pati, Sunil</creatorcontrib><creatorcontrib>Poole, Claudette</creatorcontrib><creatorcontrib>Latting, Misty</creatorcontrib><creatorcontrib>Seleme, Maria C</creatorcontrib><creatorcontrib>Yarbrough, April</creatorcontrib><creatorcontrib>Arora, Nitin</creatorcontrib><creatorcontrib>Britt, William J</creatorcontrib><creatorcontrib>Boppana, Suresh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinninti, Swetha G</au><au>Pati, Sunil</au><au>Poole, Claudette</au><au>Latting, Misty</au><au>Seleme, Maria C</au><au>Yarbrough, April</au><au>Arora, Nitin</au><au>Britt, William J</au><au>Boppana, Suresh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>147</volume><issue>5</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>In children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virological characteristics and correlation with disease severity have not been extensively studied. The primary objective in this study is to determine the correlation between SARS-CoV-2 viral load (VL) in infected children with age, disease severity, and underlying comorbidities.
Children <21 years, screened for SARS-CoV-2 at the time of hospitalization, who tested positive by polymerase chain reaction were included in this study. VL at different sites was determined and compared between groups.
Of the 102 children included in this study, 44% of the cohort had asymptomatic infection, and children with >1 comorbidity were the most at risk for severe disease. VL in children with symptomatic infection was significantly higher than in children with asymptomatic infection (3.0 × 10
vs 7.2 × 10
copies per mL;
= .001). VL in the respiratory tract was significantly higher in children <1 year, compared with older children (3.3 × 10
vs 1.3 × 10
copies per mL respectively;
< .0001), despite most infants presenting with milder illness. Besides the respiratory tract, SARS-CoV-2 RNA was also detectable in samples from the gastrointestinal tract (saliva and rectum) and blood. In 13 children for whom data on duration of polymerase chain reaction positivity was available, 12 of 13 tested positive 2 weeks after initial diagnosis, and 6 of 13 continued to test positive 4 weeks after initial diagnosis.
In hospitalized children with SARS-CoV-2, those with >1 comorbid condition experienced severe disease. SARS-CoV-2 VL in the respiratory tract is significantly higher in children with symptomatic disease and children <1 year of age.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>33622794</pmid><doi>10.1542/peds.2020-037812</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Asymptomatic Asymptomatic infection Asymptomatic Infections Child Child, Preschool Children Comorbidity Coronaviruses COVID-19 - diagnosis COVID-19 - virology COVID-19 Nucleic Acid Testing Diagnosis Gastrointestinal tract Hospitalization Humans Infant Infants Infections Nasopharynx - virology Nose - virology Pediatrics Polymerase chain reaction Rectum Rectum - virology Respiratory tract Saliva Salvia - virology SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Time Factors Viral Load Virus Shedding Young Adult |
| title | Virological Characteristics of Hospitalized Children With SARS-CoV-2 Infection |
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