The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation
The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used t...
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| Veröffentlicht in: | Scientific reports 2021-04, Vol.11 (1), p.9343-9343, Article 9343 |
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| creator | Lau, C. Kalantari, B. Batts, K. P. Ferrell, L. D. Nyberg, S. L. Graham, R. P. Moreira, Roger K. |
| description | The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. We examined the histology of normal porcine and human livers and analyzed the geometric relationships of various microanatomic structures utilizing digital tools. The Voronoi diagram model described the organization of the hepatic classic lobules with overall accuracy nearly 90% based on known histologic landmarks. We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. Therefore, we have presented evidence that Voronoi diagrams represent the basis of the two-dimensional organization of the normal liver and that this concept may have wide applicability in liver pathology and research. |
| doi_str_mv | 10.1038/s41598-021-88699-2 |
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We have also designed a Voronoi-based algorithm of hepatic zonation, which also showed an overall zonal accuracy of nearly 90%. 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P.</au><au>Ferrell, L. D.</au><au>Nyberg, S. L.</au><au>Graham, R. P.</au><au>Moreira, Roger K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><stitle>SCI REP-UK</stitle><addtitle>Sci Rep</addtitle><date>2021-04-29</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>9343</spage><epage>9343</epage><pages>9343-9343</pages><artnum>9343</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The precise characterization of the lobular architecture of the liver has been subject of investigation since the earliest historical publications, but an accurate model to describe the hepatic lobular microanatomy is yet to be proposed. Our aim was to evaluate whether Voronoi diagrams can be used to describe the classic liver lobular architecture. 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| subjects | 639/705 692/4020 692/698 Histology Humanities and Social Sciences Liver multidisciplinary Multidisciplinary Sciences Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Zonation |
| title | The Voronoi theory of the normal liver lobular architecture and its applicability in hepatic zonation |
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