REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity

Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking 1 , 2 . The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as ‘REV-ERB’) in the GABAergic (γ-aminobutyric acid-producing...

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Veröffentlicht in:	Nature (London) 2021-04, Vol.592 (7856), p.763-767
Hauptverfasser:	Ding, Guolian, Li, Xin, Hou, Xinguo, Zhou, Wenjun, Gong, Yingyun, Liu, Fuqiang, He, Yanlin, Song, Jia, Wang, Jing, Basil, Paul, Li, Wenbo, Qian, Sichong, Saha, Pradip, Wang, Jinbang, Cui, Chen, Yang, Tingting, Zou, Kexin, Han, Younghun, Amos, Christopher I., Xu, Yong, Chen, Li, Sun, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/44 38 38/39 631/443/319/1642/137/773 631/443/319/367/1562 64 64/60 Animals Biological clocks Blood Glucose Blood sugar Circadian Clocks Circadian Rhythm Circadian rhythms Depletion Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diabetes therapy Diurnal Female Firing pattern GABAergic Neurons - physiology Gene expression Genes Genotype & phenotype Glucagon Glucose Glucose - metabolism Glucose tolerance Humanities and Social Sciences Humans Insulin Insulin Resistance Intolerance Liver Liver - physiology Male Medical research Medicine, Experimental Metabolism Mice Mice, Inbred C57BL Mice, Knockout Middle Aged multidisciplinary Neurons Neurotransmission Nuclear Receptor Subfamily 1, Group D, Member 1 - physiology Nuclear receptors Phenotypes Photoperiod Physiological aspects Rhythm Rodents Science Science (multidisciplinary) Sensitivity Suprachiasmatic nucleus Suprachiasmatic Nucleus - cytology Synaptic Transmission Type 2 diabetes γ-Aminobutyric acid
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