Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats
Xylopia aethiopica is a common plant in West Africa, with wide applications in trado-medical management of several diseases. Thus, our study aimed to analyze the histology and hormonal effects of ethanol extracts of Xylopia aethiopica seeds on cadmium chloride-induced reproductive dysfunction in fem...
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| Veröffentlicht in: | JBRA assisted reproduction 2021, Vol.25 (2), p.252-256 |
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| creator | Godam, Elvis T Olaniyan, Olugbemi T Wofuru, Chiwendu D Orupabo, Clinton D Ordu, Kenneth S Gbaranor, Barinua K Dakoru, Progress D |
| description | Xylopia aethiopica is a common plant in West Africa, with wide applications in trado-medical management of several diseases. Thus, our study aimed to analyze the histology and hormonal effects of ethanol extracts of Xylopia aethiopica seeds on cadmium chloride-induced reproductive dysfunction in female Wistar rats.
We used twenty-five rats weighing 120-150g for this study. The rats were divided into five groups (n=5). Group 1: received only distilled water orally; Group 2: received 2 mg/kg cadmium chloride orally; Group 3: received 2 mg/kg cadmium chloride plus 50 mg/kg Xylopia aethiopica seeds orally; Group 4: received 2 mg/kg cadmium chloride plus 100 mg/kg Xylopia aethiopica seeds orally, and Group 5: received 100 mg/kg Xylopia aethiopica seeds only, orally. We administered the extracts for 14 days, after which we slaughtered the animals following chloroform anesthesia. We took the blood samples by cardiac puncture for hormonal assay. The ovaries and uterus were harvested for histology. We analyzed the data using ANOVA, and the differences in mean values were considered significant at p |
| doi_str_mv | 10.5935/1518-0557.20200091 |
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We used twenty-five rats weighing 120-150g for this study. The rats were divided into five groups (n=5). Group 1: received only distilled water orally; Group 2: received 2 mg/kg cadmium chloride orally; Group 3: received 2 mg/kg cadmium chloride plus 50 mg/kg Xylopia aethiopica seeds orally; Group 4: received 2 mg/kg cadmium chloride plus 100 mg/kg Xylopia aethiopica seeds orally, and Group 5: received 100 mg/kg Xylopia aethiopica seeds only, orally. We administered the extracts for 14 days, after which we slaughtered the animals following chloroform anesthesia. We took the blood samples by cardiac puncture for hormonal assay. The ovaries and uterus were harvested for histology. We analyzed the data using ANOVA, and the differences in mean values were considered significant at p<0.05.
The body weight of the rats showed a dose-dependent reduction (p<0.05), compared with the controls. Xylopia aethiopica seeds significantly (p<0.05) reversed the detrimental effects of Cadmium on LH and FSH. The histological analysis of the ovary showed significant improvement upon treatment with Xylopia aethiopica extract in a dose-dependent manner.
The ameliorative effects of Xylopia aethiopica against cadmium chloride-induced reproductive toxicity in female Wistar rats may be attributed to its antioxidant properties.</description><identifier>ISSN: 1518-0557</identifier><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20200091</identifier><identifier>PMID: 33507724</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Alcohol ; Animals ; Blood vessels ; Cadmium ; Cadmium Chloride - toxicity ; Chloride ; Drug dosages ; Enzymes ; Ethanol ; Ethanol - toxicity ; Fruit ; Gene expression ; Gonadotropins ; Herbal medicine ; Histology ; Laboratory animals ; Original ; Ovaries ; Ovary ; Pharmaceutical industry ; Plant Extracts ; Rats ; Rats, Wistar ; Reproductive system ; Seeds ; Xylopia</subject><ispartof>JBRA assisted reproduction, 2021, Vol.25 (2), p.252-256</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-3605ba4f2e62667c9ad7f019c722fa09bd09c6de5862c6247ee57ff7463b50e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083854/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083854/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33507724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godam, Elvis T</creatorcontrib><creatorcontrib>Olaniyan, Olugbemi T</creatorcontrib><creatorcontrib>Wofuru, Chiwendu D</creatorcontrib><creatorcontrib>Orupabo, Clinton D</creatorcontrib><creatorcontrib>Ordu, Kenneth S</creatorcontrib><creatorcontrib>Gbaranor, Barinua K</creatorcontrib><creatorcontrib>Dakoru, Progress D</creatorcontrib><title>Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>Xylopia aethiopica is a common plant in West Africa, with wide applications in trado-medical management of several diseases. Thus, our study aimed to analyze the histology and hormonal effects of ethanol extracts of Xylopia aethiopica seeds on cadmium chloride-induced reproductive dysfunction in female Wistar rats.
We used twenty-five rats weighing 120-150g for this study. The rats were divided into five groups (n=5). Group 1: received only distilled water orally; Group 2: received 2 mg/kg cadmium chloride orally; Group 3: received 2 mg/kg cadmium chloride plus 50 mg/kg Xylopia aethiopica seeds orally; Group 4: received 2 mg/kg cadmium chloride plus 100 mg/kg Xylopia aethiopica seeds orally, and Group 5: received 100 mg/kg Xylopia aethiopica seeds only, orally. We administered the extracts for 14 days, after which we slaughtered the animals following chloroform anesthesia. We took the blood samples by cardiac puncture for hormonal assay. The ovaries and uterus were harvested for histology. We analyzed the data using ANOVA, and the differences in mean values were considered significant at p<0.05.
The body weight of the rats showed a dose-dependent reduction (p<0.05), compared with the controls. Xylopia aethiopica seeds significantly (p<0.05) reversed the detrimental effects of Cadmium on LH and FSH. The histological analysis of the ovary showed significant improvement upon treatment with Xylopia aethiopica extract in a dose-dependent manner.
The ameliorative effects of Xylopia aethiopica against cadmium chloride-induced reproductive toxicity in female Wistar rats may be attributed to its antioxidant properties.</description><subject>Alcohol</subject><subject>Animals</subject><subject>Blood vessels</subject><subject>Cadmium</subject><subject>Cadmium Chloride - toxicity</subject><subject>Chloride</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Ethanol</subject><subject>Ethanol - toxicity</subject><subject>Fruit</subject><subject>Gene expression</subject><subject>Gonadotropins</subject><subject>Herbal medicine</subject><subject>Histology</subject><subject>Laboratory animals</subject><subject>Original</subject><subject>Ovaries</subject><subject>Ovary</subject><subject>Pharmaceutical industry</subject><subject>Plant Extracts</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproductive system</subject><subject>Seeds</subject><subject>Xylopia</subject><issn>1518-0557</issn><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU9rFTEUxYMottR-ARcScONmaiaZJDMbQR71DxTcKLoL9yV3-lJmkjHJlL5v4Mc2j7aP6iqH3N893MMh5HXLLuQg5PtWtn3DpNQXnHHG2NA-I6fHz-dP9Ak5z_mmIu3QctGxl-RECMm05t0p-fNrP8XFAwUsO1-VBVoVhDjRjOgo3pUEttC8LkvCnDHTDbjZrzO1uykm77Dxwa22svEW0p5CcPQ6BnCxpGoYMi3xzltf9tQHCm6dCh1xhgnpT58LJJqg5FfkxQhTxvOH94z8-HT5ffOlufr2-evm41VjO8FKIxSTW-hGjoorpe0ATo81mdWcj8CGrWODVQ5lr7hVvNOIUo-j7pTYSoZKnJEP977Lup3RWQw132SW5Od6vIngzb-T4HfmOt6anvWil101ePdgkOLvFXMxs88WpwkCxjUb3lWu7VV7QN_-h97ENYUaz3DF-VDJQVSK31M2xZwTjsdjWmYOXZtDleZQpXnsui69eRrjuPLYrPgL4q6npw</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Godam, Elvis T</creator><creator>Olaniyan, Olugbemi T</creator><creator>Wofuru, Chiwendu D</creator><creator>Orupabo, Clinton D</creator><creator>Ordu, Kenneth S</creator><creator>Gbaranor, Barinua K</creator><creator>Dakoru, Progress D</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2021</creationdate><title>Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats</title><author>Godam, Elvis T ; Olaniyan, Olugbemi T ; Wofuru, Chiwendu D ; Orupabo, Clinton D ; Ordu, Kenneth S ; Gbaranor, Barinua K ; Dakoru, Progress D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-3605ba4f2e62667c9ad7f019c722fa09bd09c6de5862c6247ee57ff7463b50e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alcohol</topic><topic>Animals</topic><topic>Blood vessels</topic><topic>Cadmium</topic><topic>Cadmium Chloride - toxicity</topic><topic>Chloride</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Ethanol</topic><topic>Ethanol - toxicity</topic><topic>Fruit</topic><topic>Gene expression</topic><topic>Gonadotropins</topic><topic>Herbal medicine</topic><topic>Histology</topic><topic>Laboratory animals</topic><topic>Original</topic><topic>Ovaries</topic><topic>Ovary</topic><topic>Pharmaceutical industry</topic><topic>Plant Extracts</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproductive system</topic><topic>Seeds</topic><topic>Xylopia</topic><toplevel>online_resources</toplevel><creatorcontrib>Godam, Elvis T</creatorcontrib><creatorcontrib>Olaniyan, Olugbemi T</creatorcontrib><creatorcontrib>Wofuru, Chiwendu D</creatorcontrib><creatorcontrib>Orupabo, Clinton D</creatorcontrib><creatorcontrib>Ordu, Kenneth S</creatorcontrib><creatorcontrib>Gbaranor, Barinua K</creatorcontrib><creatorcontrib>Dakoru, Progress D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JBRA assisted reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godam, Elvis T</au><au>Olaniyan, Olugbemi T</au><au>Wofuru, Chiwendu D</au><au>Orupabo, Clinton D</au><au>Ordu, Kenneth S</au><au>Gbaranor, Barinua K</au><au>Dakoru, Progress D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats</atitle><jtitle>JBRA assisted reproduction</jtitle><addtitle>JBRA Assist Reprod</addtitle><date>2021</date><risdate>2021</risdate><volume>25</volume><issue>2</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>1518-0557</issn><issn>1517-5693</issn><eissn>1518-0557</eissn><abstract>Xylopia aethiopica is a common plant in West Africa, with wide applications in trado-medical management of several diseases. Thus, our study aimed to analyze the histology and hormonal effects of ethanol extracts of Xylopia aethiopica seeds on cadmium chloride-induced reproductive dysfunction in female Wistar rats.
We used twenty-five rats weighing 120-150g for this study. The rats were divided into five groups (n=5). Group 1: received only distilled water orally; Group 2: received 2 mg/kg cadmium chloride orally; Group 3: received 2 mg/kg cadmium chloride plus 50 mg/kg Xylopia aethiopica seeds orally; Group 4: received 2 mg/kg cadmium chloride plus 100 mg/kg Xylopia aethiopica seeds orally, and Group 5: received 100 mg/kg Xylopia aethiopica seeds only, orally. We administered the extracts for 14 days, after which we slaughtered the animals following chloroform anesthesia. We took the blood samples by cardiac puncture for hormonal assay. The ovaries and uterus were harvested for histology. We analyzed the data using ANOVA, and the differences in mean values were considered significant at p<0.05.
The body weight of the rats showed a dose-dependent reduction (p<0.05), compared with the controls. Xylopia aethiopica seeds significantly (p<0.05) reversed the detrimental effects of Cadmium on LH and FSH. The histological analysis of the ovary showed significant improvement upon treatment with Xylopia aethiopica extract in a dose-dependent manner.
The ameliorative effects of Xylopia aethiopica against cadmium chloride-induced reproductive toxicity in female Wistar rats may be attributed to its antioxidant properties.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>33507724</pmid><doi>10.5935/1518-0557.20200091</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Animals Blood vessels Cadmium Cadmium Chloride - toxicity Chloride Drug dosages Enzymes Ethanol Ethanol - toxicity Fruit Gene expression Gonadotropins Herbal medicine Histology Laboratory animals Original Ovaries Ovary Pharmaceutical industry Plant Extracts Rats Rats, Wistar Reproductive system Seeds Xylopia |
| title | Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats |
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