Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions
The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of foll...
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| Veröffentlicht in: | Science advances 2021-04, Vol.7 (18) |
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| creator | Yoon, Hyo-Jin Lee, Yong Jae Baek, Sewoom Chung, Young Shin Kim, Dae-Hyun Lee, Jae Hoon Shin, Yong Cheol Shin, Young Min Ryu, Chungsoon Kim, Hye-Seon Ahn, So Hyun Kim, Heeyon Won, Young Bin Lee, Inha Jeon, Myung Jae Cho, Si Hyun Lee, Byung Seok Sung, Hak-Joon Choi, Young Sik |
| description | The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy. |
| doi_str_mv | 10.1126/sciadv.abe8873 |
| format | Article |
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A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.abe8873</identifier><identifier>PMID: 33910892</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Applied Sciences and Engineering ; Cancer ; Female ; Health and Medicine ; Hormones ; Humans ; Hydrogels ; Ovariectomy ; Ovary ; Rats ; SciAdv r-articles ; Spheroids, Cellular</subject><ispartof>Science advances, 2021-04, Vol.7 (18)</ispartof><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</rights><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. 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A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.</description><subject>Animals</subject><subject>Applied Sciences and Engineering</subject><subject>Cancer</subject><subject>Female</subject><subject>Health and Medicine</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Ovariectomy</subject><subject>Ovary</subject><subject>Rats</subject><subject>SciAdv r-articles</subject><subject>Spheroids, Cellular</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1Lw0AUXESxpfbqUfbopXU_8rG5CFLUCgUvel42bzftSpKtu0kg_noTW6We3sCbmTe8QeiakiWlLLkLYJXulio3QqT8DE0ZT-MFiyNxfoInaB7CByGERkkS0-wSTTjPKBEZmyK7dr5ytcGqbRx4W6vGuhrnPe5UgLZU3n4ZjXe99m5rSqxNaTvje-wK7Do1gLDfGe-sDrhx2JtBZH42VtVY96FoaxgtwxW6KFQZzPw4Z-j96fFttV5sXp9fVg-bBfCMNAuAvCC6yMasHIaQIoqTLBc5pCASkhIGKRWMc6EZzQkQSElOaAGMiwEyPkP3B999m1dGg6kbr0q597Ya4kqnrPy_qe1Obl0nBRGUJ9FgcHs08O6zNaGRlQ1gylLVxrVBsuGHgjLBR-ryQAXvQvCm-DtDiRwrkoeK5LGiQXBzGu6P_lsI_wbZgZIf</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Yoon, Hyo-Jin</creator><creator>Lee, Yong Jae</creator><creator>Baek, Sewoom</creator><creator>Chung, Young Shin</creator><creator>Kim, Dae-Hyun</creator><creator>Lee, Jae Hoon</creator><creator>Shin, Yong Cheol</creator><creator>Shin, Young Min</creator><creator>Ryu, Chungsoon</creator><creator>Kim, Hye-Seon</creator><creator>Ahn, So Hyun</creator><creator>Kim, Heeyon</creator><creator>Won, Young Bin</creator><creator>Lee, Inha</creator><creator>Jeon, Myung Jae</creator><creator>Cho, Si Hyun</creator><creator>Lee, Byung Seok</creator><creator>Sung, Hak-Joon</creator><creator>Choi, Young Sik</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5965-7205</orcidid><orcidid>https://orcid.org/0000-0002-1196-5452</orcidid><orcidid>https://orcid.org/0000-0003-2061-8169</orcidid><orcidid>https://orcid.org/0000-0003-2312-2484</orcidid><orcidid>https://orcid.org/0000-0003-0297-3116</orcidid><orcidid>https://orcid.org/0000-0002-8757-4634</orcidid><orcidid>https://orcid.org/0000-0002-8818-454X</orcidid><orcidid>https://orcid.org/0000-0002-1418-5929</orcidid><orcidid>https://orcid.org/0000-0002-7345-7090</orcidid><orcidid>https://orcid.org/0000-0002-3128-8815</orcidid><orcidid>https://orcid.org/0000-0002-3525-3812</orcidid><orcidid>https://orcid.org/0000-0001-5582-1488</orcidid><orcidid>https://orcid.org/0000-0003-2718-6645</orcidid><orcidid>https://orcid.org/0000-0003-4869-6281</orcidid><orcidid>https://orcid.org/0000-0002-6107-5837</orcidid></search><sort><creationdate>20210401</creationdate><title>Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions</title><author>Yoon, Hyo-Jin ; 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| subjects | Animals Applied Sciences and Engineering Cancer Female Health and Medicine Hormones Humans Hydrogels Ovariectomy Ovary Rats SciAdv r-articles Spheroids, Cellular |
| title | Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions |
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