NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit, engage and respond to T cell help (signal 2). Failure to receive signal 2 within a defined time window results in B cell apoptosis, yet the mechanisms that enforce dependence on co-stimulation are incompletel...

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Veröffentlicht in:	Nature immunology 2020-10, Vol.21 (10), p.1267-1279
Hauptverfasser:	Tan, Corey, Hiwa, Ryosuke, Mueller, James L., Vykunta, Vivasvan, Hibiya, Kenta, Noviski, Mark, Huizar, John, Brooks, Jeremy F., Garcia, Jose, Heyn, Cheryl, Li, Zhongmei, Marson, Alexander, Zikherman, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/40/2508 631/250/2152/2153 631/250/2502 Animals Antigen-antibody reactions Antigens Apoptosis Autoantigens B cells B-cell receptor B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine CCL3 protein CCL4 protein CD4 antigen CD86 antigen Cell Communication Cell Proliferation Cell receptors Cells, Cultured Chemokines Cytokines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genetic aspects Health aspects Immune response Immunity, Humoral Immunological tolerance Immunology Immunomodulation Infectious Diseases Intercellular adhesion molecule 1 Lymphocyte Activation Lymphocytes Lymphocytes B Lymphocytes T Mice Mice, Knockout Myc protein Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Nuclear receptors Nur77 protein Orphan nuclear receptors Receptors, Antigen, B-Cell - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Signal Transduction T-Lymphocytes, Helper-Inducer - immunology
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