Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity

Abstract Liver-related diseases including drug-induced liver injury are becoming increasingly prominent in AIDS patients. Cobicistat (COBI) is the backbone of multiple regimens for antiretroviral therapy. The current work investigated the mechanisms of adverse drug-drug interactions associated with...

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Veröffentlicht in:	Toxicological sciences 2021-04, Vol.181 (1), p.58-67
Hauptverfasser:	Shehu, Amina I, Zhu, Junjie, Li, Jianhua, Lu, Jie, McMahon, Deborah, Xie, Wen, Gonzalez, Frank J, Ma, Xiaochao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Clinical and Translational Toxicology Cobicistat Constitutive Androstane Receptor Humans Mice Pregnane X Receptor Receptors, Cytoplasmic and Nuclear Receptors, Steroid Xenobiotics - toxicity
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