Precision Redox: The Key for Antioxidant Pharmacology
The redox balance of cells provides a stable microenvironment for biological macromolecules to perform their physiological functions. As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based...
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| Veröffentlicht in: | Antioxidants & redox signaling 2021-05, Vol.34 (14), p.1069-1082 |
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| creator | Meng, Jiao Lv, Zhenyu Zhang, Yingmin Wang, Yuanyuan Qiao, Xinhua Sun, Chuanxin Chen, Yuzhe Guo, Miaomiao Han, Wensheng Ye, Aojun Xie, Ting Chu, Boyu Shi, Chang Yang, Shangpo Chen, Chang |
| description | The redox balance of cells provides a stable microenvironment for biological macromolecules to perform their physiological functions. As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based therapeutic strategies have not yet shown satisfactory results. To find the key reason is of great significance.
We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the "5R" principle of precision redox in antioxidant pharmacology: "Right species, Right place, Right time, Right level, and Right target."
Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population.
Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the "5R" principle rather than continuing to apply global nonspecific antioxidant treatments.
. 34, 1069-1082. |
| doi_str_mv | 10.1089/ars.2020.8212 |
| format | Article |
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We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the "5R" principle of precision redox in antioxidant pharmacology: "Right species, Right place, Right time, Right level, and Right target."
Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population.
Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the "5R" principle rather than continuing to apply global nonspecific antioxidant treatments.
. 34, 1069-1082.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2020.8212</identifier><identifier>PMID: 33270507</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Antioxidants ; Antioxidants - therapeutic use ; Aquatic plants ; Cellular Microenvironment - drug effects ; Cellular Microenvironment - genetics ; Dietary Supplements ; Forum Review ; Humans ; Macromolecules ; Metabolic Diseases - diet therapy ; Metabolic Diseases - drug therapy ; Metabolic Diseases - metabolism ; Metabolic Diseases - pathology ; Microenvironments ; Oxidation-Reduction - drug effects ; Oxidative Stress - genetics ; Pharmacology ; Physiology ; Population studies ; Reactive Nitrogen Species - metabolism ; Reactive Oxygen Species - metabolism ; Redox properties ; Signal Transduction - drug effects</subject><ispartof>Antioxidants & redox signaling, 2021-05, Vol.34 (14), p.1069-1082</ispartof><rights>Copyright Mary Ann Liebert, Inc. May 1, 2021</rights><rights>Jiao Meng 2020; Published by Mary Ann Liebert, Inc. 2020 Jiao Meng et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c6e5840ae09091ccad8dd19fd62068069139248d0e2f8542dce3e0acb734b6d03</citedby><cites>FETCH-LOGICAL-c415t-c6e5840ae09091ccad8dd19fd62068069139248d0e2f8542dce3e0acb734b6d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33270507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Jiao</creatorcontrib><creatorcontrib>Lv, Zhenyu</creatorcontrib><creatorcontrib>Zhang, Yingmin</creatorcontrib><creatorcontrib>Wang, Yuanyuan</creatorcontrib><creatorcontrib>Qiao, Xinhua</creatorcontrib><creatorcontrib>Sun, Chuanxin</creatorcontrib><creatorcontrib>Chen, Yuzhe</creatorcontrib><creatorcontrib>Guo, Miaomiao</creatorcontrib><creatorcontrib>Han, Wensheng</creatorcontrib><creatorcontrib>Ye, Aojun</creatorcontrib><creatorcontrib>Xie, Ting</creatorcontrib><creatorcontrib>Chu, Boyu</creatorcontrib><creatorcontrib>Shi, Chang</creatorcontrib><creatorcontrib>Yang, Shangpo</creatorcontrib><creatorcontrib>Chen, Chang</creatorcontrib><title>Precision Redox: The Key for Antioxidant Pharmacology</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>The redox balance of cells provides a stable microenvironment for biological macromolecules to perform their physiological functions. As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based therapeutic strategies have not yet shown satisfactory results. To find the key reason is of great significance.
We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the "5R" principle of precision redox in antioxidant pharmacology: "Right species, Right place, Right time, Right level, and Right target."
Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population.
Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the "5R" principle rather than continuing to apply global nonspecific antioxidant treatments.
. 34, 1069-1082.</description><subject>Antioxidants</subject><subject>Antioxidants - therapeutic use</subject><subject>Aquatic plants</subject><subject>Cellular Microenvironment - drug effects</subject><subject>Cellular Microenvironment - genetics</subject><subject>Dietary Supplements</subject><subject>Forum Review</subject><subject>Humans</subject><subject>Macromolecules</subject><subject>Metabolic Diseases - diet therapy</subject><subject>Metabolic Diseases - drug therapy</subject><subject>Metabolic Diseases - metabolism</subject><subject>Metabolic Diseases - pathology</subject><subject>Microenvironments</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative Stress - genetics</subject><subject>Pharmacology</subject><subject>Physiology</subject><subject>Population studies</subject><subject>Reactive Nitrogen Species - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Redox properties</subject><subject>Signal Transduction - drug effects</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LAzEQhoMotlaPXmXBi5etk2Q3m_UglOIXFixSzyFNsu2W7aYmu9L-e1Nai3qagXl4mZkHoUsMfQw8v5XO9wkQ6HOCyRHq4jTN4izD7HjbExoDZ0kHnXm_AACCMZyiDqUkgxSyLkrHzqjSl7aO3o2267toMjfRq9lEhXXRoG5Kuy61rJtoPJduKZWt7Gxzjk4KWXlzsa899PH4MBk-x6O3p5fhYBSrBKdNrJhJeQLSQA45VkpqrjXOC80IMA4sxzQnCddgSMHThGhlqAGpphlNpkwD7aH7Xe6qnS5NGNeNk5VYuXIp3UZYWYq_k7qci5n9Ehw45BSHgJt9gLOfrfGNWJZemaqStbGtFyRhGcNhFRLQ63_owrauDucJkuI8vIsRFqh4RylnvXemOCyDQWyFiCBEbIWIrZDAX_2-4ED_GKDfKsiFqg</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Meng, Jiao</creator><creator>Lv, Zhenyu</creator><creator>Zhang, Yingmin</creator><creator>Wang, Yuanyuan</creator><creator>Qiao, Xinhua</creator><creator>Sun, Chuanxin</creator><creator>Chen, Yuzhe</creator><creator>Guo, Miaomiao</creator><creator>Han, Wensheng</creator><creator>Ye, Aojun</creator><creator>Xie, Ting</creator><creator>Chu, Boyu</creator><creator>Shi, Chang</creator><creator>Yang, Shangpo</creator><creator>Chen, Chang</creator><general>Mary Ann Liebert, Inc</general><general>Mary Ann Liebert, Inc., publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210501</creationdate><title>Precision Redox: The Key for Antioxidant Pharmacology</title><author>Meng, Jiao ; 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As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based therapeutic strategies have not yet shown satisfactory results. To find the key reason is of great significance.
We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the "5R" principle of precision redox in antioxidant pharmacology: "Right species, Right place, Right time, Right level, and Right target."
Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population.
Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the "5R" principle rather than continuing to apply global nonspecific antioxidant treatments.
. 34, 1069-1082.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>33270507</pmid><doi>10.1089/ars.2020.8212</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Antioxidants - therapeutic use Aquatic plants Cellular Microenvironment - drug effects Cellular Microenvironment - genetics Dietary Supplements Forum Review Humans Macromolecules Metabolic Diseases - diet therapy Metabolic Diseases - drug therapy Metabolic Diseases - metabolism Metabolic Diseases - pathology Microenvironments Oxidation-Reduction - drug effects Oxidative Stress - genetics Pharmacology Physiology Population studies Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Redox properties Signal Transduction - drug effects |
| title | Precision Redox: The Key for Antioxidant Pharmacology |
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