Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes

The apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1), the main AP-endonuclease of the DNA base excision repair pathway, is a key molecule of interest to researchers due to its unsuspected roles in different nonrepair activities, such as: i) adaptive cell response to genotoxic stress, ii) regulat...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100569-100569, Article 100569
Hauptverfasser:	Mangiapane, Giovanna, Parolini, Isabella, Conte, Kristel, Malfatti, Matilde Clarissa, Corsi, Jessica, Sanchez, Massimo, Pietrantoni, Agostina, D’Agostino, Vito G., Tell, Gianluca
Format:	Artikel
Sprache:	eng
Schlagworte:	apurinic/apyrimidinic endodeoxyribonuclease 1 base excision repair biomarker exosomes extracellular vesicles genotoxic damage proteasome
Online-Zugang:	Volltext
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