Nucleic acid-based drug delivery strategies

Nucleic acids have not been widely considered as an optimal material for drug delivery. Indeed, unmodified nucleic acids are enzymatically unstable, too hydrophilic for cell uptake and payload encapsulation, and may cause unintended biological responses such as immune system activation and prolongat...

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Veröffentlicht in:	Journal of controlled release 2020-07, Vol.323, p.240-252
Hauptverfasser:	Tan, Xuyu, Jia, Fei, Wang, Ping, Zhang, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamer DNA amphiphile DNA nanotechnology Drug delivery Drug Delivery Systems Nanostructures Nanotechnology Nucleic acid Nucleic Acids Pharmaceutical Preparations
Online-Zugang:	Volltext
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