ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

Patients with the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) historically showed inferior survival with standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Phase II studies demonstrated that adding the immunomodulatory agent...

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Veröffentlicht in:	Journal of clinical oncology 2021-04, Vol.39 (12), p.1317-1328
Hauptverfasser:	Nowakowski, Grzegorz S, Chiappella, Annalisa, Gascoyne, Randy D, Scott, David W, Zhang, Qingyuan, Jurczak, Wojciech, Özcan, Muhit, Hong, Xiaonan, Zhu, Jun, Jin, Jie, Belada, David, Bergua, Juan Miguel, Piazza, Francesco, Mócikova, Heidi, Molinari, Anna Lia, Yoon, Dok Hyun, Cavallo, Federica, Tani, Monica, Yamamoto, Kazuhito, Izutsu, Koji, Kato, Koji, Czuczman, Myron, Hersey, Sarah, Kilcoyne, Adrian, Russo, Jacqueline, Hudak, Krista, Zhang, Jingshan, Wade, Steve, Witzig, Thomas E, Vitolo, Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Doxorubicin - administration & dosage Doxorubicin - adverse effects Female Humans Lenalidomide - administration & dosage Lenalidomide - adverse effects Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Male Middle Aged ORIGINAL REPORTS Prednisone - administration & dosage Prednisone - adverse effects Rituximab - administration & dosage Rituximab - adverse effects Vincristine - administration & dosage Vincristine - adverse effects Young Adult
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