VPS13D promotes peroxisome biogenesis

The VPS13 gene family consists of VPS13A-D in mammals. Although all four genes have been linked to human diseases, their cellular functions are poorly understood, particularly those of VPS13D. We generated and characterized knockouts of each VPS13 gene in HeLa cells. Among the individual knockouts,...

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Veröffentlicht in:	The Journal of cell biology 2021-05, Vol.220 (5), p.1
Hauptverfasser:	Baldwin, Heather A, Wang, Chunxin, Kanfer, Gil, Shah, Hetal V, Velayos-Baeza, Antonio, Dulovic-Mahlow, Marija, Brüggemann, Norbert, Anding, Allyson, Baehrecke, Eric H, Maric, Dragan, Prinz, William A, Youle, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Biochemistry Biosynthesis Cell lines Cytology Evolution Fibroblasts HEK293 Cells HeLa Cells Humans Membrane and lipid biology Mitochondria Mitochondria - genetics Mitochondria - metabolism Morphology Mutation Mutation - genetics Organelles Peroxisomes - genetics Peroxisomes - metabolism Proteins - genetics Proteins - metabolism Systems and Computational Biology
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