Vitamin D and Microbiota: Is There a Link with Allergies?
There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2021-04, Vol.22 (8), p.4288 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 4288 |
| container_title | International journal of molecular sciences |
| container_volume | 22 |
| creator | Murdaca, Giuseppe Gerosa, Alessandra Paladin, Francesca Petrocchi, Lorena Banchero, Sara Gangemi, Sebastiano |
| description | There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Dysbiosis also seems to be associated with allergies, in particular asthma, atopic dermatitis, and food allergy. Even though the effect of vitamin D supplementation on these pathologies is still unknown, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier. It also influences the immune system mainly through the vitamin D receptor (VDR). In this review, we summarize the influence of the microbiome and vitamin D on the immune system with a particular focus on allergic diseases and we discuss the necessity of further studies on the use of probiotics and of a correct intake of vitamin D. |
| doi_str_mv | 10.3390/ijms22084288 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8074777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2548687399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-7d2e6a20001370bdb7e181d8b76802f3fc881e56acb13c858926427f9fb3f67d3</originalsourceid><addsrcrecordid>eNpdkUlPwzAQhS0EolC4cUaWuHAg4CXxwgFUla1SEZfC1XISp3XJUuwExL_HVUtVOI1H_vzGbx4AJxhdUirRlZ1XnhAkYiLEDjjAMSERQozvbp174ND7OUKEkkTug154SOLQHAD5Zltd2RreQV3n8Nlmrklt0-prOPJwMjPOQA3Htn6HX7adwUFZGje1xt8egb1Cl94cr2sfvD7cT4ZP0fjlcTQcjKMsxqSNeE4M0wQhhClHaZ5ygwXORcqZQKSgRSYENgnTWYppJhIhCYsJL2SR0oLxnPbBzUp30aWVyTNTt06XauFspd23arRVf29qO1PT5lMJxGPOeRA4Xwu45qMzvlWV9ZkpS12bpvOKJGF7y5ksoGf_0HnTuTrYC1QsmOBUykBdrKiwK--dKTafwUgtM1HbmQT8dNvABv4Ngf4ASq-FmA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2548687399</pqid></control><display><type>article</type><title>Vitamin D and Microbiota: Is There a Link with Allergies?</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Murdaca, Giuseppe ; Gerosa, Alessandra ; Paladin, Francesca ; Petrocchi, Lorena ; Banchero, Sara ; Gangemi, Sebastiano</creator><creatorcontrib>Murdaca, Giuseppe ; Gerosa, Alessandra ; Paladin, Francesca ; Petrocchi, Lorena ; Banchero, Sara ; Gangemi, Sebastiano</creatorcontrib><description>There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Dysbiosis also seems to be associated with allergies, in particular asthma, atopic dermatitis, and food allergy. Even though the effect of vitamin D supplementation on these pathologies is still unknown, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier. It also influences the immune system mainly through the vitamin D receptor (VDR). In this review, we summarize the influence of the microbiome and vitamin D on the immune system with a particular focus on allergic diseases and we discuss the necessity of further studies on the use of probiotics and of a correct intake of vitamin D.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22084288</identifier><identifier>PMID: 33924232</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergic diseases ; Allergies ; Arthritis ; Asthma ; Atopic dermatitis ; Autoimmune diseases ; Bacteria ; Calciferol ; Chronic conditions ; Dysbacteriosis ; Food allergies ; Immune system ; Infections ; Inflammatory bowel diseases ; Metabolism ; Metabolites ; Microbiomes ; Microbiota ; Microorganisms ; Pathogens ; Permeability ; Probiotics ; Respiratory system ; Review ; Rheumatoid arthritis ; Skin ; Systemic lupus erythematosus ; Vagina ; Vitamin D ; Vitamin D receptors ; Vitamin deficiency</subject><ispartof>International journal of molecular sciences, 2021-04, Vol.22 (8), p.4288</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-7d2e6a20001370bdb7e181d8b76802f3fc881e56acb13c858926427f9fb3f67d3</citedby><cites>FETCH-LOGICAL-c412t-7d2e6a20001370bdb7e181d8b76802f3fc881e56acb13c858926427f9fb3f67d3</cites><orcidid>0000-0002-6403-6905</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074777/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074777/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33924232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murdaca, Giuseppe</creatorcontrib><creatorcontrib>Gerosa, Alessandra</creatorcontrib><creatorcontrib>Paladin, Francesca</creatorcontrib><creatorcontrib>Petrocchi, Lorena</creatorcontrib><creatorcontrib>Banchero, Sara</creatorcontrib><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><title>Vitamin D and Microbiota: Is There a Link with Allergies?</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Dysbiosis also seems to be associated with allergies, in particular asthma, atopic dermatitis, and food allergy. Even though the effect of vitamin D supplementation on these pathologies is still unknown, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier. It also influences the immune system mainly through the vitamin D receptor (VDR). In this review, we summarize the influence of the microbiome and vitamin D on the immune system with a particular focus on allergic diseases and we discuss the necessity of further studies on the use of probiotics and of a correct intake of vitamin D.</description><subject>Allergic diseases</subject><subject>Allergies</subject><subject>Arthritis</subject><subject>Asthma</subject><subject>Atopic dermatitis</subject><subject>Autoimmune diseases</subject><subject>Bacteria</subject><subject>Calciferol</subject><subject>Chronic conditions</subject><subject>Dysbacteriosis</subject><subject>Food allergies</subject><subject>Immune system</subject><subject>Infections</subject><subject>Inflammatory bowel diseases</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Pathogens</subject><subject>Permeability</subject><subject>Probiotics</subject><subject>Respiratory system</subject><subject>Review</subject><subject>Rheumatoid arthritis</subject><subject>Skin</subject><subject>Systemic lupus erythematosus</subject><subject>Vagina</subject><subject>Vitamin D</subject><subject>Vitamin D receptors</subject><subject>Vitamin deficiency</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUlPwzAQhS0EolC4cUaWuHAg4CXxwgFUla1SEZfC1XISp3XJUuwExL_HVUtVOI1H_vzGbx4AJxhdUirRlZ1XnhAkYiLEDjjAMSERQozvbp174ND7OUKEkkTug154SOLQHAD5Zltd2RreQV3n8Nlmrklt0-prOPJwMjPOQA3Htn6HX7adwUFZGje1xt8egb1Cl94cr2sfvD7cT4ZP0fjlcTQcjKMsxqSNeE4M0wQhhClHaZ5ygwXORcqZQKSgRSYENgnTWYppJhIhCYsJL2SR0oLxnPbBzUp30aWVyTNTt06XauFspd23arRVf29qO1PT5lMJxGPOeRA4Xwu45qMzvlWV9ZkpS12bpvOKJGF7y5ksoGf_0HnTuTrYC1QsmOBUykBdrKiwK--dKTafwUgtM1HbmQT8dNvABv4Ngf4ASq-FmA</recordid><startdate>20210420</startdate><enddate>20210420</enddate><creator>Murdaca, Giuseppe</creator><creator>Gerosa, Alessandra</creator><creator>Paladin, Francesca</creator><creator>Petrocchi, Lorena</creator><creator>Banchero, Sara</creator><creator>Gangemi, Sebastiano</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6403-6905</orcidid></search><sort><creationdate>20210420</creationdate><title>Vitamin D and Microbiota: Is There a Link with Allergies?</title><author>Murdaca, Giuseppe ; Gerosa, Alessandra ; Paladin, Francesca ; Petrocchi, Lorena ; Banchero, Sara ; Gangemi, Sebastiano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-7d2e6a20001370bdb7e181d8b76802f3fc881e56acb13c858926427f9fb3f67d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Allergic diseases</topic><topic>Allergies</topic><topic>Arthritis</topic><topic>Asthma</topic><topic>Atopic dermatitis</topic><topic>Autoimmune diseases</topic><topic>Bacteria</topic><topic>Calciferol</topic><topic>Chronic conditions</topic><topic>Dysbacteriosis</topic><topic>Food allergies</topic><topic>Immune system</topic><topic>Infections</topic><topic>Inflammatory bowel diseases</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Pathogens</topic><topic>Permeability</topic><topic>Probiotics</topic><topic>Respiratory system</topic><topic>Review</topic><topic>Rheumatoid arthritis</topic><topic>Skin</topic><topic>Systemic lupus erythematosus</topic><topic>Vagina</topic><topic>Vitamin D</topic><topic>Vitamin D receptors</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murdaca, Giuseppe</creatorcontrib><creatorcontrib>Gerosa, Alessandra</creatorcontrib><creatorcontrib>Paladin, Francesca</creatorcontrib><creatorcontrib>Petrocchi, Lorena</creatorcontrib><creatorcontrib>Banchero, Sara</creatorcontrib><creatorcontrib>Gangemi, Sebastiano</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murdaca, Giuseppe</au><au>Gerosa, Alessandra</au><au>Paladin, Francesca</au><au>Petrocchi, Lorena</au><au>Banchero, Sara</au><au>Gangemi, Sebastiano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D and Microbiota: Is There a Link with Allergies?</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-04-20</date><risdate>2021</risdate><volume>22</volume><issue>8</issue><spage>4288</spage><pages>4288-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>There is increasing recognition of the importance of both the microbiome and vitamin D in states of health and disease. Microbiome studies have already demonstrated unique microbial patterns in systemic autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. Dysbiosis also seems to be associated with allergies, in particular asthma, atopic dermatitis, and food allergy. Even though the effect of vitamin D supplementation on these pathologies is still unknown, vitamin D deficiency deeply influences the microbiome by altering the microbiome composition and the integrity of the gut epithelial barrier. It also influences the immune system mainly through the vitamin D receptor (VDR). In this review, we summarize the influence of the microbiome and vitamin D on the immune system with a particular focus on allergic diseases and we discuss the necessity of further studies on the use of probiotics and of a correct intake of vitamin D.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33924232</pmid><doi>10.3390/ijms22084288</doi><orcidid>https://orcid.org/0000-0002-6403-6905</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-04, Vol.22 (8), p.4288 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8074777 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Allergic diseases Allergies Arthritis Asthma Atopic dermatitis Autoimmune diseases Bacteria Calciferol Chronic conditions Dysbacteriosis Food allergies Immune system Infections Inflammatory bowel diseases Metabolism Metabolites Microbiomes Microbiota Microorganisms Pathogens Permeability Probiotics Respiratory system Review Rheumatoid arthritis Skin Systemic lupus erythematosus Vagina Vitamin D Vitamin D receptors Vitamin deficiency |
| title | Vitamin D and Microbiota: Is There a Link with Allergies? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T23%3A31%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20D%20and%20Microbiota:%20Is%20There%20a%20Link%20with%20Allergies?&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Murdaca,%20Giuseppe&rft.date=2021-04-20&rft.volume=22&rft.issue=8&rft.spage=4288&rft.pages=4288-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms22084288&rft_dat=%3Cproquest_pubme%3E2548687399%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2548687399&rft_id=info:pmid/33924232&rfr_iscdi=true |