Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory, motor and/or autonomic, with consequent reduction, delay or discontinuation of vincristine-chemotherapy, but also pain, disabi...

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Veröffentlicht in:	International journal of molecular sciences 2021-04, Vol.22 (8), p.4112
Hauptverfasser:	Triarico, Silvia, Romano, Alberto, Attinà, Giorgio, Capozza, Michele Antonio, Maurizi, Palma, Mastrangelo, Stefano, Ruggiero, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Autonomic nervous system Binding sites Cancer therapies Cell division Chemotherapy Child Clinical trials Constipation Drug dosages Endothelium Gabapentin Gene polymorphism Glutamic acid Glutamine Health services Hearing loss Humans Leukemia Microtubules Mitochondria Mitosis Molecular modelling Nervous system Neurotoxicity Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - prevention & control Pain Pathogenesis Patients Pediatrics Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - prevention & control Peripheral neuropathy Pharmacodynamics Pharmacokinetics Prophylaxis Proteins Pyridostigmine Pyridoxine Quality of life Questionnaires Review Risk analysis Risk factors Tubulin Modulators - administration & dosage Tubulin Modulators - pharmacokinetics Tubulin Modulators - toxicity Tumors Vincristine Vincristine - pharmacokinetics Vincristine - toxicity
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