Antibody Libraries as Tools to Discover Functional Antibodies and Receptor Pleiotropism

Most antibodies currently in use have been selected based on their binding affinity. However, nowadays, antibodies that can not only bind but can also alter the function of cell surface signaling components are increasingly sought after as therapeutic drugs. Therefore, the identification of such fun...

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Veröffentlicht in:	International journal of molecular sciences 2021-04, Vol.22 (8), p.4123
Hauptverfasser:	Lin, Chih-Wei, Lerner, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Antibodies Antibodies - genetics Antibodies - immunology Antibody libraries Antigens Binding sites Cell fate Cell surface Cloning Combinatorial analysis Drug Discovery - methods FDA approval Genes Genetic engineering Genetic Pleiotropy Genotype & phenotype Humans Immunoglobulins Library technology Ligands Medical research Peptide Library Proteins Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - immunology Review Signal transduction Stem cells Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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