Mesenchymal stem cells induce tumor stroma formation and epithelial‑mesenchymal transition through SPARC expression in colorectal cancer

Tumor‑stroma interactions serve a crucial role in the development of colorectal cancer (CRC), in which secreted protein acidic and rich in cysteine (SPARC) has been implicated. Due to interactions between cancer and stromal cells [mesenchymal stem cells (MSCs)], SPARC gene expression is markedly upr...

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Veröffentlicht in:	Oncology reports 2021-06, Vol.45 (6), p.1, Article 104
Hauptverfasser:	Naito, Toshikatsu, Yuge, Ryo, Kitadai, Yasuhiko, Takigawa, Hidehiko, Higashi, Yukihito, Kuwai, Toshio, Kuraoka, Kazuya, Tanaka, Shinji, Chayama, Kazuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biotechnology Colorectal cancer Cysteine Cytokines Fibroblasts Gene expression Genes Genetic research Growth factors Hospitals Medical colleges Metastasis Patients Pharmaceutical industry Prognosis Proteins RNA RNA sequencing Scientific equipment and supplies industry Smooth muscle Stem cells
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