Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics
Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function i...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2021-04, Vol.10 (8), p.1760 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 1760 |
| container_title | Journal of clinical medicine |
| container_volume | 10 |
| creator | Flahault, Adrien Altit, Gabriel Sonea, Aurélie Gervais, Anne-Sophie Mian, Muhammad Oneeb Rehman Wu, Rong Desbrousses, Eva Mai, Ly Cloutier, Anik Simoneau, Jessica Lapointe, Anie Villeneuve, Andréanne Garceau, Patrick White, Michel Bigras, Jean-Luc Luu, Thuy Mai Nuyt, Anne Monique |
| description | Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e' wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population. |
| doi_str_mv | 10.3390/jcm10081760 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8072582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2520850887</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-bd9297a3d7171effd5cd07661b80bfb7c6e381a2aef301ad9c53e0fd0d4e586b3</originalsourceid><addsrcrecordid>eNpdkd1rFDEUxYMottQ--S4BXwRZvZnsTDIvwrrYKiwq-AE-hUxyp5tlJmnzYel_b7atZTUPyYX8zuHeewh5zuAN5z283ZmZAUgmOnhEjhsQYgFc8scH9RE5TWkH9Ui5bJh4So6qlPXtEo5J2eCY6U_0OTozIf2WYzG5RKTaW3pWvMkueOo8_RWKv6ArW6ac6PsQfVXFG_o1YsY43-KrlIJx-lZx7fKWfsbgddYTXW911KaCLmVn0jPyZNRTwtP794T8OPvwff1xsfly_mm92izMEvq8GGzf9EJzK5hgOI62NRZE17FBwjAOwnTIJdONxpED07Y3LUcYLdgltrIb-Al5d-d7WYYZrdmPqSd1Gd2s440K2ql_f7zbqovwW0kQTSubavDq3iCGq4Ipq9klg9OkPYaSVNM2INu6WFHRl_-hu1Cir-NVqu-hq9fe8PUdZWJIKeL40AwDtU9UHSRa6ReH_T-wf_PjfwD1vJ5g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2599065992</pqid></control><display><type>article</type><title>Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Flahault, Adrien ; Altit, Gabriel ; Sonea, Aurélie ; Gervais, Anne-Sophie ; Mian, Muhammad Oneeb Rehman ; Wu, Rong ; Desbrousses, Eva ; Mai, Ly ; Cloutier, Anik ; Simoneau, Jessica ; Lapointe, Anie ; Villeneuve, Andréanne ; Garceau, Patrick ; White, Michel ; Bigras, Jean-Luc ; Luu, Thuy Mai ; Nuyt, Anne Monique</creator><creatorcontrib>Flahault, Adrien ; Altit, Gabriel ; Sonea, Aurélie ; Gervais, Anne-Sophie ; Mian, Muhammad Oneeb Rehman ; Wu, Rong ; Desbrousses, Eva ; Mai, Ly ; Cloutier, Anik ; Simoneau, Jessica ; Lapointe, Anie ; Villeneuve, Andréanne ; Garceau, Patrick ; White, Michel ; Bigras, Jean-Luc ; Luu, Thuy Mai ; Nuyt, Anne Monique</creatorcontrib><description>Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e' wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10081760</identifier><identifier>PMID: 33919540</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Birth weight ; Cardiomyocytes ; Cardiovascular disease ; Clinical medicine ; Ejection fraction ; Gestational age ; Heart rate ; Hospitals ; Lung diseases ; Preeclampsia ; Premature birth ; Standard deviation ; Steroids ; Values ; Young adults</subject><ispartof>Journal of clinical medicine, 2021-04, Vol.10 (8), p.1760</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-bd9297a3d7171effd5cd07661b80bfb7c6e381a2aef301ad9c53e0fd0d4e586b3</citedby><cites>FETCH-LOGICAL-c409t-bd9297a3d7171effd5cd07661b80bfb7c6e381a2aef301ad9c53e0fd0d4e586b3</cites><orcidid>0000-0001-5141-0964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072582/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072582/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33919540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flahault, Adrien</creatorcontrib><creatorcontrib>Altit, Gabriel</creatorcontrib><creatorcontrib>Sonea, Aurélie</creatorcontrib><creatorcontrib>Gervais, Anne-Sophie</creatorcontrib><creatorcontrib>Mian, Muhammad Oneeb Rehman</creatorcontrib><creatorcontrib>Wu, Rong</creatorcontrib><creatorcontrib>Desbrousses, Eva</creatorcontrib><creatorcontrib>Mai, Ly</creatorcontrib><creatorcontrib>Cloutier, Anik</creatorcontrib><creatorcontrib>Simoneau, Jessica</creatorcontrib><creatorcontrib>Lapointe, Anie</creatorcontrib><creatorcontrib>Villeneuve, Andréanne</creatorcontrib><creatorcontrib>Garceau, Patrick</creatorcontrib><creatorcontrib>White, Michel</creatorcontrib><creatorcontrib>Bigras, Jean-Luc</creatorcontrib><creatorcontrib>Luu, Thuy Mai</creatorcontrib><creatorcontrib>Nuyt, Anne Monique</creatorcontrib><title>Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e' wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population.</description><subject>Birth weight</subject><subject>Cardiomyocytes</subject><subject>Cardiovascular disease</subject><subject>Clinical medicine</subject><subject>Ejection fraction</subject><subject>Gestational age</subject><subject>Heart rate</subject><subject>Hospitals</subject><subject>Lung diseases</subject><subject>Preeclampsia</subject><subject>Premature birth</subject><subject>Standard deviation</subject><subject>Steroids</subject><subject>Values</subject><subject>Young adults</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkd1rFDEUxYMottQ--S4BXwRZvZnsTDIvwrrYKiwq-AE-hUxyp5tlJmnzYel_b7atZTUPyYX8zuHeewh5zuAN5z283ZmZAUgmOnhEjhsQYgFc8scH9RE5TWkH9Ui5bJh4So6qlPXtEo5J2eCY6U_0OTozIf2WYzG5RKTaW3pWvMkueOo8_RWKv6ArW6ac6PsQfVXFG_o1YsY43-KrlIJx-lZx7fKWfsbgddYTXW911KaCLmVn0jPyZNRTwtP794T8OPvwff1xsfly_mm92izMEvq8GGzf9EJzK5hgOI62NRZE17FBwjAOwnTIJdONxpED07Y3LUcYLdgltrIb-Al5d-d7WYYZrdmPqSd1Gd2s440K2ql_f7zbqovwW0kQTSubavDq3iCGq4Ipq9klg9OkPYaSVNM2INu6WFHRl_-hu1Cir-NVqu-hq9fe8PUdZWJIKeL40AwDtU9UHSRa6ReH_T-wf_PjfwD1vJ5g</recordid><startdate>20210418</startdate><enddate>20210418</enddate><creator>Flahault, Adrien</creator><creator>Altit, Gabriel</creator><creator>Sonea, Aurélie</creator><creator>Gervais, Anne-Sophie</creator><creator>Mian, Muhammad Oneeb Rehman</creator><creator>Wu, Rong</creator><creator>Desbrousses, Eva</creator><creator>Mai, Ly</creator><creator>Cloutier, Anik</creator><creator>Simoneau, Jessica</creator><creator>Lapointe, Anie</creator><creator>Villeneuve, Andréanne</creator><creator>Garceau, Patrick</creator><creator>White, Michel</creator><creator>Bigras, Jean-Luc</creator><creator>Luu, Thuy Mai</creator><creator>Nuyt, Anne Monique</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5141-0964</orcidid></search><sort><creationdate>20210418</creationdate><title>Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics</title><author>Flahault, Adrien ; Altit, Gabriel ; Sonea, Aurélie ; Gervais, Anne-Sophie ; Mian, Muhammad Oneeb Rehman ; Wu, Rong ; Desbrousses, Eva ; Mai, Ly ; Cloutier, Anik ; Simoneau, Jessica ; Lapointe, Anie ; Villeneuve, Andréanne ; Garceau, Patrick ; White, Michel ; Bigras, Jean-Luc ; Luu, Thuy Mai ; Nuyt, Anne Monique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-bd9297a3d7171effd5cd07661b80bfb7c6e381a2aef301ad9c53e0fd0d4e586b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Birth weight</topic><topic>Cardiomyocytes</topic><topic>Cardiovascular disease</topic><topic>Clinical medicine</topic><topic>Ejection fraction</topic><topic>Gestational age</topic><topic>Heart rate</topic><topic>Hospitals</topic><topic>Lung diseases</topic><topic>Preeclampsia</topic><topic>Premature birth</topic><topic>Standard deviation</topic><topic>Steroids</topic><topic>Values</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flahault, Adrien</creatorcontrib><creatorcontrib>Altit, Gabriel</creatorcontrib><creatorcontrib>Sonea, Aurélie</creatorcontrib><creatorcontrib>Gervais, Anne-Sophie</creatorcontrib><creatorcontrib>Mian, Muhammad Oneeb Rehman</creatorcontrib><creatorcontrib>Wu, Rong</creatorcontrib><creatorcontrib>Desbrousses, Eva</creatorcontrib><creatorcontrib>Mai, Ly</creatorcontrib><creatorcontrib>Cloutier, Anik</creatorcontrib><creatorcontrib>Simoneau, Jessica</creatorcontrib><creatorcontrib>Lapointe, Anie</creatorcontrib><creatorcontrib>Villeneuve, Andréanne</creatorcontrib><creatorcontrib>Garceau, Patrick</creatorcontrib><creatorcontrib>White, Michel</creatorcontrib><creatorcontrib>Bigras, Jean-Luc</creatorcontrib><creatorcontrib>Luu, Thuy Mai</creatorcontrib><creatorcontrib>Nuyt, Anne Monique</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flahault, Adrien</au><au>Altit, Gabriel</au><au>Sonea, Aurélie</au><au>Gervais, Anne-Sophie</au><au>Mian, Muhammad Oneeb Rehman</au><au>Wu, Rong</au><au>Desbrousses, Eva</au><au>Mai, Ly</au><au>Cloutier, Anik</au><au>Simoneau, Jessica</au><au>Lapointe, Anie</au><au>Villeneuve, Andréanne</au><au>Garceau, Patrick</au><au>White, Michel</au><au>Bigras, Jean-Luc</au><au>Luu, Thuy Mai</au><au>Nuyt, Anne Monique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2021-04-18</date><risdate>2021</risdate><volume>10</volume><issue>8</issue><spage>1760</spage><pages>1760-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e' wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33919540</pmid><doi>10.3390/jcm10081760</doi><orcidid>https://orcid.org/0000-0001-5141-0964</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2021-04, Vol.10 (8), p.1760 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8072582 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Birth weight Cardiomyocytes Cardiovascular disease Clinical medicine Ejection fraction Gestational age Heart rate Hospitals Lung diseases Preeclampsia Premature birth Standard deviation Steroids Values Young adults |
| title | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T15%3A48%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Left%20Ventricle%20Structure%20and%20Function%20in%20Young%20Adults%20Born%20Very%20Preterm%20and%20Association%20with%20Neonatal%20Characteristics&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Flahault,%20Adrien&rft.date=2021-04-18&rft.volume=10&rft.issue=8&rft.spage=1760&rft.pages=1760-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm10081760&rft_dat=%3Cproquest_pubme%3E2520850887%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2599065992&rft_id=info:pmid/33919540&rfr_iscdi=true |