Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candida auris , C. parapsilosis and C. albicans Biofilms
Recently two peptides isolated from the Cuban freshwater snail (Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of , and the less common species measured as the decrease of metab...
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| Veröffentlicht in: | Pathogens (Basel) 2021-04, Vol.10 (4), p.496 |
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| creator | Raber, Heinz Fabian Sejfijaj, Jetmira Kissmann, Ann-Kathrin Wittgens, Andreas Gonzalez-Garcia, Melaine Alba, Annia Vázquez, Antonio A Morales Vicente, Fidel E Erviti, Julio Pérez Kubiczek, Dennis Otero-González, Anselmo Rodríguez, Armando Ständker, Ludger Rosenau, Frank |
| description | Recently two peptides isolated from the Cuban freshwater snail
(Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of
,
and the less common species
measured as the decrease of metabolic activity in the resazurin reduction assay for planktonic cells. Although these activities were low, Pom-1 and Pom-2 turned out to be highly potent inhibitors of biofilm formation for the three
species tested. Whereas Pom-1 was slightly more active against
and
as representatives of the more common
species Pom-2 showed no preference and was fully active also against biofilms of the more uncommon species
. Pom-1 and Pom-2 may represent promising lead structures for the development of a classical peptide optimization strategy with the realistic aim to further increase antibiofilm properties and other pharmacologic parameters and to generate finally the first antifungal drug with a pronounced dedication against
biofilms. |
| doi_str_mv | 10.3390/pathogens10040496 |
| format | Article |
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(Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of
,
and the less common species
measured as the decrease of metabolic activity in the resazurin reduction assay for planktonic cells. Although these activities were low, Pom-1 and Pom-2 turned out to be highly potent inhibitors of biofilm formation for the three
species tested. Whereas Pom-1 was slightly more active against
and
as representatives of the more common
species Pom-2 showed no preference and was fully active also against biofilms of the more uncommon species
. Pom-1 and Pom-2 may represent promising lead structures for the development of a classical peptide optimization strategy with the realistic aim to further increase antibiofilm properties and other pharmacologic parameters and to generate finally the first antifungal drug with a pronounced dedication against
biofilms.</description><identifier>ISSN: 2076-0817</identifier><identifier>EISSN: 2076-0817</identifier><identifier>DOI: 10.3390/pathogens10040496</identifier><identifier>PMID: 33924039</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antifungal agents ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Antimicrobial peptides ; Biofilms ; Candida ; Communication ; Disease control ; Drug resistance ; Fungicides ; Nosocomial infections ; Optimization ; Pathogens ; Peptides ; Pesticides ; Planktonic cells ; Pomacea ; Species ; Values</subject><ispartof>Pathogens (Basel), 2021-04, Vol.10 (4), p.496</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2635-8767 ; 0000-0002-9297-6419 ; 0000-0003-3190-8786 ; 0000-0002-8436-4260 ; 0000-0001-5921-3770</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072573/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072573/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33924039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raber, Heinz Fabian</creatorcontrib><creatorcontrib>Sejfijaj, Jetmira</creatorcontrib><creatorcontrib>Kissmann, Ann-Kathrin</creatorcontrib><creatorcontrib>Wittgens, Andreas</creatorcontrib><creatorcontrib>Gonzalez-Garcia, Melaine</creatorcontrib><creatorcontrib>Alba, Annia</creatorcontrib><creatorcontrib>Vázquez, Antonio A</creatorcontrib><creatorcontrib>Morales Vicente, Fidel E</creatorcontrib><creatorcontrib>Erviti, Julio Pérez</creatorcontrib><creatorcontrib>Kubiczek, Dennis</creatorcontrib><creatorcontrib>Otero-González, Anselmo</creatorcontrib><creatorcontrib>Rodríguez, Armando</creatorcontrib><creatorcontrib>Ständker, Ludger</creatorcontrib><creatorcontrib>Rosenau, Frank</creatorcontrib><title>Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candida auris , C. parapsilosis and C. albicans Biofilms</title><title>Pathogens (Basel)</title><addtitle>Pathogens</addtitle><description>Recently two peptides isolated from the Cuban freshwater snail
(Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of
,
and the less common species
measured as the decrease of metabolic activity in the resazurin reduction assay for planktonic cells. Although these activities were low, Pom-1 and Pom-2 turned out to be highly potent inhibitors of biofilm formation for the three
species tested. Whereas Pom-1 was slightly more active against
and
as representatives of the more common
species Pom-2 showed no preference and was fully active also against biofilms of the more uncommon species
. Pom-1 and Pom-2 may represent promising lead structures for the development of a classical peptide optimization strategy with the realistic aim to further increase antibiofilm properties and other pharmacologic parameters and to generate finally the first antifungal drug with a pronounced dedication against
biofilms.</description><subject>Antifungal agents</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial peptides</subject><subject>Biofilms</subject><subject>Candida</subject><subject>Communication</subject><subject>Disease control</subject><subject>Drug resistance</subject><subject>Fungicides</subject><subject>Nosocomial infections</subject><subject>Optimization</subject><subject>Pathogens</subject><subject>Peptides</subject><subject>Pesticides</subject><subject>Planktonic cells</subject><subject>Pomacea</subject><subject>Species</subject><subject>Values</subject><issn>2076-0817</issn><issn>2076-0817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkEtLxDAQx4MoKrofwIsEvFrNo22Si7AuvkBwD3ous-1kjbRJTboLfgK_tl1f6FzmP6_fDEPIEWdnUhp23sPwHJboE2csZ7kpt8i-YKrMmOZq-4_eI5OUXthomm3iXbI3AkTOpNkn71M_uM7VMSwctHSO_eAaTHQeuoxT8M2nEtTG0G0k1Ai0D_gGHug0Ip3Wg1sjhSU4nwY6G0dcAxRW0SV6SmdntIcIfXJtSGNmQxxz0C5cDT7RSxesa7t0SHYstAkn3_6APF1fPc5us_uHm7vZ9D7rRcmHrIC80Kib0uS50FaiQQ1omOKyUdJqU9ZFoZnBGlgONleCNwvLtFGWa2tQHpCLL26_WnTY1OiHCG3VR9dBfKsCuOp_xbvnahnWlWZKFEqOgJNvQAyvK0xD9RJW0Y83V6KQjAtlSj12Hf9d88v_ebz8AHjOiCQ</recordid><startdate>20210420</startdate><enddate>20210420</enddate><creator>Raber, Heinz Fabian</creator><creator>Sejfijaj, Jetmira</creator><creator>Kissmann, Ann-Kathrin</creator><creator>Wittgens, Andreas</creator><creator>Gonzalez-Garcia, Melaine</creator><creator>Alba, Annia</creator><creator>Vázquez, Antonio A</creator><creator>Morales Vicente, Fidel E</creator><creator>Erviti, Julio Pérez</creator><creator>Kubiczek, Dennis</creator><creator>Otero-González, Anselmo</creator><creator>Rodríguez, Armando</creator><creator>Ständker, Ludger</creator><creator>Rosenau, Frank</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2635-8767</orcidid><orcidid>https://orcid.org/0000-0002-9297-6419</orcidid><orcidid>https://orcid.org/0000-0003-3190-8786</orcidid><orcidid>https://orcid.org/0000-0002-8436-4260</orcidid><orcidid>https://orcid.org/0000-0001-5921-3770</orcidid></search><sort><creationdate>20210420</creationdate><title>Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candida auris , C. parapsilosis and C. albicans Biofilms</title><author>Raber, Heinz Fabian ; Sejfijaj, Jetmira ; Kissmann, Ann-Kathrin ; Wittgens, Andreas ; Gonzalez-Garcia, Melaine ; Alba, Annia ; Vázquez, Antonio A ; Morales Vicente, Fidel E ; Erviti, Julio Pérez ; Kubiczek, Dennis ; Otero-González, Anselmo ; Rodríguez, Armando ; Ständker, Ludger ; Rosenau, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p261t-5a458e8d694428f3e9e8ae90713d73f896c55809eca04af4721dbf0897f18f9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antifungal agents</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial peptides</topic><topic>Biofilms</topic><topic>Candida</topic><topic>Communication</topic><topic>Disease control</topic><topic>Drug resistance</topic><topic>Fungicides</topic><topic>Nosocomial infections</topic><topic>Optimization</topic><topic>Pathogens</topic><topic>Peptides</topic><topic>Pesticides</topic><topic>Planktonic cells</topic><topic>Pomacea</topic><topic>Species</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raber, Heinz Fabian</creatorcontrib><creatorcontrib>Sejfijaj, Jetmira</creatorcontrib><creatorcontrib>Kissmann, Ann-Kathrin</creatorcontrib><creatorcontrib>Wittgens, Andreas</creatorcontrib><creatorcontrib>Gonzalez-Garcia, Melaine</creatorcontrib><creatorcontrib>Alba, Annia</creatorcontrib><creatorcontrib>Vázquez, Antonio A</creatorcontrib><creatorcontrib>Morales Vicente, Fidel E</creatorcontrib><creatorcontrib>Erviti, Julio Pérez</creatorcontrib><creatorcontrib>Kubiczek, Dennis</creatorcontrib><creatorcontrib>Otero-González, Anselmo</creatorcontrib><creatorcontrib>Rodríguez, Armando</creatorcontrib><creatorcontrib>Ständker, Ludger</creatorcontrib><creatorcontrib>Rosenau, Frank</creatorcontrib><collection>PubMed</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathogens (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raber, Heinz Fabian</au><au>Sejfijaj, Jetmira</au><au>Kissmann, Ann-Kathrin</au><au>Wittgens, Andreas</au><au>Gonzalez-Garcia, Melaine</au><au>Alba, Annia</au><au>Vázquez, Antonio A</au><au>Morales Vicente, Fidel E</au><au>Erviti, Julio Pérez</au><au>Kubiczek, Dennis</au><au>Otero-González, Anselmo</au><au>Rodríguez, Armando</au><au>Ständker, Ludger</au><au>Rosenau, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candida auris , C. parapsilosis and C. albicans Biofilms</atitle><jtitle>Pathogens (Basel)</jtitle><addtitle>Pathogens</addtitle><date>2021-04-20</date><risdate>2021</risdate><volume>10</volume><issue>4</issue><spage>496</spage><pages>496-</pages><issn>2076-0817</issn><eissn>2076-0817</eissn><abstract>Recently two peptides isolated from the Cuban freshwater snail
(Pilsbry, 1927) were described to have antimicrobial activity against bacterial pathogens. Here we show considerable activities of Pom-1 and Pom-2 to reduce the viability of
,
and the less common species
measured as the decrease of metabolic activity in the resazurin reduction assay for planktonic cells. Although these activities were low, Pom-1 and Pom-2 turned out to be highly potent inhibitors of biofilm formation for the three
species tested. Whereas Pom-1 was slightly more active against
and
as representatives of the more common
species Pom-2 showed no preference and was fully active also against biofilms of the more uncommon species
. Pom-1 and Pom-2 may represent promising lead structures for the development of a classical peptide optimization strategy with the realistic aim to further increase antibiofilm properties and other pharmacologic parameters and to generate finally the first antifungal drug with a pronounced dedication against
biofilms.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33924039</pmid><doi>10.3390/pathogens10040496</doi><orcidid>https://orcid.org/0000-0003-2635-8767</orcidid><orcidid>https://orcid.org/0000-0002-9297-6419</orcidid><orcidid>https://orcid.org/0000-0003-3190-8786</orcidid><orcidid>https://orcid.org/0000-0002-8436-4260</orcidid><orcidid>https://orcid.org/0000-0001-5921-3770</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Antifungal agents Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial peptides Biofilms Candida Communication Disease control Drug resistance Fungicides Nosocomial infections Optimization Pathogens Peptides Pesticides Planktonic cells Pomacea Species Values |
| title | Antimicrobial Peptides Pom-1 and Pom-2 from Pomacea poeyana Are Active against Candida auris , C. parapsilosis and C. albicans Biofilms |
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