An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and cross-reacts with the murine isoform of the protein...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-04, Vol.118 (16), p.1-10
Hauptverfasser:	Millul, Jacopo, Bassi, Gabriele, Mock, Jacqueline, Elsayed, Abdullah, Pellegrino, Christian, Zana, Aureliano, Plaza, Sheila Dakhel, Nadal, Lisa, Gloger, Andreas, Schmidt, Eleonore, Biancofiore, Ilaria, Donckele, Etienne J., Samain, Florent, Neri, Dario, Cazzamalli, Samuele
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies Antigens Biodistribution Biological Sciences Chimeric antigen receptors Conjugates Fibroblast activation protein Fibroblasts Fluorescein Fluorescence In vivo methods and tests Interleukin 2 Intravenous administration Ligands Localization Lutetium Lymphocytes Lymphocytes T Proteins Surgical implants Tumors
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