Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer

Metastasis is the major cause of cancer-related death, but whether metastatic lesions exhibit the same cellular composition as primary tumors has yet to be elucidated. To investigate the cellular heterogeneity of metastatic colorectal cancer (CRC), we established 72 patient-derived organoids (PDOs)...

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Veröffentlicht in:	Stem cell reports 2021-04, Vol.16 (4), p.954-967
Hauptverfasser:	Okamoto, Takuya, duVerle, David, Yaginuma, Katsuyuki, Natsume, Yasuko, Yamanaka, Hitomi, Kusama, Daisuke, Fukuda, Mayuko, Yamamoto, Mayuko, Perraudeau, Fanny, Srivastava, Upasna, Kashima, Yukie, Suzuki, Ayako, Kuze, Yuuta, Takahashi, Yu, Ueno, Masashi, Sakai, Yoshiharu, Noda, Tetsuo, Tsuda, Koji, Suzuki, Yutaka, Nagayama, Satoshi, Yao, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Gene Expression Profiling Gene Expression Regulation, Neoplastic Granulocyte Colony-Stimulating Factor - metabolism Humans metastasis Neoplasm Metastasis Organoids - metabolism Organoids - pathology patient-derived organoids Resource scRNA-seq
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