The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity
Overweight and obesity in childhood and adolescence represent major public health problems of our century, and account for increased morbidity and mortality in adult life. Irisin and Fibroblast Growth Factor 21 (FGF-21) have been proposed as prognostic and/or diagnostic biomarkers in subjects with o...
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| Veröffentlicht in: | Nutrients 2021-04, Vol.13 (4), p.1274 |
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| creator | Karampatsou, Sofia I Genitsaridi, Sofia M Michos, Athanasios Kourkouni, Eleni Kourlaba, Georgia Kassari, Penio Manios, Yannis Charmandari, Evangelia |
| description | Overweight and obesity in childhood and adolescence represent major public health problems of our century, and account for increased morbidity and mortality in adult life. Irisin and Fibroblast Growth Factor 21 (FGF-21) have been proposed as prognostic and/or diagnostic biomarkers in subjects with obesity and metabolic syndrome, because they increase earlier than other traditional biomarkers. We determined the concentrations of Irisin and FGF-21 in children and adolescents with overweight and obesity before and after one year of a life-style intervention program of diet and physical exercise and explored the impact of body mass index (BMI) reduction on the concentrations of Irisin, FGF-21 and other cardiometabolic risk factors. Three hundred and ten (
= 310) children and adolescents (mean age ± SD: 10.5 ± 2.9 years) were studied prospectively. Following one year of the life-style intervention program, there was a significant decrease in BMI (
= 0.001), waist-to-hip ratio (
= 0.024), waist-to-height ratio (
= 0.024), and Irisin concentrations (
= 0.001), and an improvement in cardiometabolic risk factors. There was no alteration in FGF-21 concentrations. These findings indicate that Irisin concentrations decreased significantly as a result of BMI reduction in children and adolescents with overweight and obesity. Further studies are required to investigate the potential role of Irisin as a biomarker for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors. |
| doi_str_mv | 10.3390/nu13041274 |
| format | Article |
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= 310) children and adolescents (mean age ± SD: 10.5 ± 2.9 years) were studied prospectively. Following one year of the life-style intervention program, there was a significant decrease in BMI (
= 0.001), waist-to-hip ratio (
= 0.024), waist-to-height ratio (
= 0.024), and Irisin concentrations (
= 0.001), and an improvement in cardiometabolic risk factors. There was no alteration in FGF-21 concentrations. These findings indicate that Irisin concentrations decreased significantly as a result of BMI reduction in children and adolescents with overweight and obesity. Further studies are required to investigate the potential role of Irisin as a biomarker for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13041274</identifier><identifier>PMID: 33924457</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescents ; Biomarkers ; Body mass ; Body mass index ; Body size ; Body weight ; Children ; Exercise ; Fibroblast growth factors ; Growth factors ; Health problems ; Health risks ; Insulin resistance ; Metabolic disorders ; Metabolic syndrome ; Morbidity ; Obesity ; Physical exercise ; Public health ; Risk analysis ; Risk factors</subject><ispartof>Nutrients, 2021-04, Vol.13 (4), p.1274</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-448320826189879f97acfb4e529b1f9952463f5cc78f2b1c721e55cb0ce8d3fc3</citedby><cites>FETCH-LOGICAL-c406t-448320826189879f97acfb4e529b1f9952463f5cc78f2b1c721e55cb0ce8d3fc3</cites><orcidid>0000-0001-6486-114X ; 0000-0002-0851-6998 ; 0000-0003-2464-1825 ; 0000-0003-0229-3938</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070027/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070027/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33924457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karampatsou, Sofia I</creatorcontrib><creatorcontrib>Genitsaridi, Sofia M</creatorcontrib><creatorcontrib>Michos, Athanasios</creatorcontrib><creatorcontrib>Kourkouni, Eleni</creatorcontrib><creatorcontrib>Kourlaba, Georgia</creatorcontrib><creatorcontrib>Kassari, Penio</creatorcontrib><creatorcontrib>Manios, Yannis</creatorcontrib><creatorcontrib>Charmandari, Evangelia</creatorcontrib><title>The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Overweight and obesity in childhood and adolescence represent major public health problems of our century, and account for increased morbidity and mortality in adult life. Irisin and Fibroblast Growth Factor 21 (FGF-21) have been proposed as prognostic and/or diagnostic biomarkers in subjects with obesity and metabolic syndrome, because they increase earlier than other traditional biomarkers. We determined the concentrations of Irisin and FGF-21 in children and adolescents with overweight and obesity before and after one year of a life-style intervention program of diet and physical exercise and explored the impact of body mass index (BMI) reduction on the concentrations of Irisin, FGF-21 and other cardiometabolic risk factors. Three hundred and ten (
= 310) children and adolescents (mean age ± SD: 10.5 ± 2.9 years) were studied prospectively. Following one year of the life-style intervention program, there was a significant decrease in BMI (
= 0.001), waist-to-hip ratio (
= 0.024), waist-to-height ratio (
= 0.024), and Irisin concentrations (
= 0.001), and an improvement in cardiometabolic risk factors. There was no alteration in FGF-21 concentrations. These findings indicate that Irisin concentrations decreased significantly as a result of BMI reduction in children and adolescents with overweight and obesity. Further studies are required to investigate the potential role of Irisin as a biomarker for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors.</description><subject>Adolescents</subject><subject>Biomarkers</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Children</subject><subject>Exercise</subject><subject>Fibroblast growth factors</subject><subject>Growth factors</subject><subject>Health problems</subject><subject>Health risks</subject><subject>Insulin resistance</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Morbidity</subject><subject>Obesity</subject><subject>Physical exercise</subject><subject>Public health</subject><subject>Risk analysis</subject><subject>Risk factors</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkd1u1DAQhS0EolXpDQ-ALHGDkAL-S5zcIFXb3XallRaJch0lznjjKmsX29myb8Oj4jSlFHxjy-ebozMzCL2l5BPnFflsR8qJoEyKF-iUEcmyohD85bP3CToP4ZZMRxJZ8NfoJFUyIXJ5in7d9ICXWoOK2Gnc4I3RkH2LxwHw2kbwB7DROIu_erfzzX6CLg1E3NgOL3-CVyYATvram2Dsw_fqapUxihfOqlTsm6k-4CQuejN0HmbqonMDhIkI-N7EHm8P4O_B7PrZfNtCMPH4Br3SzRDg_PE-Q99Xy5vFdbbZXq0XF5tMCVLETIiSM1KygpZVKStdyUbpVkDOqpbqqsqZKLjOlZKlZi1VklHIc9USBWXHteJn6Mvseze2e-jm5EN9582-8cfaNab-V7Gmr3fuUJdpqoTJZPDh0cC7HyOEWO9Nam8YGgtuDDXLU76iSJNP6Pv_0Fs3epvaSxQntBCMTtTHmVLeheBBP4WhpJ52X__dfYLfPY__hP7ZNP8NBy6qJQ</recordid><startdate>20210413</startdate><enddate>20210413</enddate><creator>Karampatsou, Sofia I</creator><creator>Genitsaridi, Sofia M</creator><creator>Michos, Athanasios</creator><creator>Kourkouni, Eleni</creator><creator>Kourlaba, Georgia</creator><creator>Kassari, Penio</creator><creator>Manios, Yannis</creator><creator>Charmandari, Evangelia</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6486-114X</orcidid><orcidid>https://orcid.org/0000-0002-0851-6998</orcidid><orcidid>https://orcid.org/0000-0003-2464-1825</orcidid><orcidid>https://orcid.org/0000-0003-0229-3938</orcidid></search><sort><creationdate>20210413</creationdate><title>The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity</title><author>Karampatsou, Sofia I ; Genitsaridi, Sofia M ; Michos, Athanasios ; Kourkouni, Eleni ; Kourlaba, Georgia ; Kassari, Penio ; Manios, Yannis ; Charmandari, Evangelia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-448320826189879f97acfb4e529b1f9952463f5cc78f2b1c721e55cb0ce8d3fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescents</topic><topic>Biomarkers</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Children</topic><topic>Exercise</topic><topic>Fibroblast growth factors</topic><topic>Growth factors</topic><topic>Health problems</topic><topic>Health risks</topic><topic>Insulin resistance</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Morbidity</topic><topic>Obesity</topic><topic>Physical exercise</topic><topic>Public health</topic><topic>Risk analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karampatsou, Sofia I</creatorcontrib><creatorcontrib>Genitsaridi, Sofia M</creatorcontrib><creatorcontrib>Michos, Athanasios</creatorcontrib><creatorcontrib>Kourkouni, Eleni</creatorcontrib><creatorcontrib>Kourlaba, Georgia</creatorcontrib><creatorcontrib>Kassari, Penio</creatorcontrib><creatorcontrib>Manios, Yannis</creatorcontrib><creatorcontrib>Charmandari, Evangelia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karampatsou, Sofia I</au><au>Genitsaridi, Sofia M</au><au>Michos, Athanasios</au><au>Kourkouni, Eleni</au><au>Kourlaba, Georgia</au><au>Kassari, Penio</au><au>Manios, Yannis</au><au>Charmandari, Evangelia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2021-04-13</date><risdate>2021</risdate><volume>13</volume><issue>4</issue><spage>1274</spage><pages>1274-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Overweight and obesity in childhood and adolescence represent major public health problems of our century, and account for increased morbidity and mortality in adult life. Irisin and Fibroblast Growth Factor 21 (FGF-21) have been proposed as prognostic and/or diagnostic biomarkers in subjects with obesity and metabolic syndrome, because they increase earlier than other traditional biomarkers. We determined the concentrations of Irisin and FGF-21 in children and adolescents with overweight and obesity before and after one year of a life-style intervention program of diet and physical exercise and explored the impact of body mass index (BMI) reduction on the concentrations of Irisin, FGF-21 and other cardiometabolic risk factors. Three hundred and ten (
= 310) children and adolescents (mean age ± SD: 10.5 ± 2.9 years) were studied prospectively. Following one year of the life-style intervention program, there was a significant decrease in BMI (
= 0.001), waist-to-hip ratio (
= 0.024), waist-to-height ratio (
= 0.024), and Irisin concentrations (
= 0.001), and an improvement in cardiometabolic risk factors. There was no alteration in FGF-21 concentrations. These findings indicate that Irisin concentrations decreased significantly as a result of BMI reduction in children and adolescents with overweight and obesity. Further studies are required to investigate the potential role of Irisin as a biomarker for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33924457</pmid><doi>10.3390/nu13041274</doi><orcidid>https://orcid.org/0000-0001-6486-114X</orcidid><orcidid>https://orcid.org/0000-0002-0851-6998</orcidid><orcidid>https://orcid.org/0000-0003-2464-1825</orcidid><orcidid>https://orcid.org/0000-0003-0229-3938</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2021-04, Vol.13 (4), p.1274 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adolescents Biomarkers Body mass Body mass index Body size Body weight Children Exercise Fibroblast growth factors Growth factors Health problems Health risks Insulin resistance Metabolic disorders Metabolic syndrome Morbidity Obesity Physical exercise Public health Risk analysis Risk factors |
| title | The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity |
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