Low JAK2 V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional CALR or MPL Gene Mutations

(Janus kinase 2) V617F, (Calreticulin) exon 9, and (receptor for thrombopoietin) exon 10 mutations are associated with the vast majority of Ph-negative chronic myeloproliferative neoplasms (MPNs). These mutations affect sequential stages of proliferative signal transduction and therefore, after the...

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Veröffentlicht in:	Genes 2021-04, Vol.12 (4), p.559
Hauptverfasser:	Makarik, Tatiana V, Abdullaev, Adhamjon O, Nikulina, Elena E, Treglazova, Svetlana A, Stepanova, Elena E, Subortseva, Irina N, Kovrigina, Alla M, Melikyan, Anait L, Kulikov, Sergei M, Sudarikov, Andrey B
Format:	Artikel
Sprache:	eng
Schlagworte:	Age groups Alleles Amino acids Bone marrow Calreticulin Genetic analysis Hematology Hyperplasia Janus kinase Janus kinase 2 Kinases Leukemia Medical prognosis Mutation Proteins Signal transduction Thrombopoietin Tumors
Online-Zugang:	Volltext
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