The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk
The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the rela...
Gespeichert in:
| Veröffentlicht in: | International journal of environmental research and public health 2021-04, Vol.18 (8), p.3926 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 3926 |
| container_title | International journal of environmental research and public health |
| container_volume | 18 |
| creator | Tiozzo, Eduard Rodriguez, Allan Konefal, Janet Farkas, Gary J Maher, Jennifer L Lewis, John E |
| description | The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (
= 34), those with longer HIV duration (
= 48) were on average older (
= 0.02), reported lower consumption of alcohol (
= 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR,
= 0.02), were also more likely to be a woman (
= 0.06), and have higher levels of fasting insulin (
= 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (
= 0.02 and
= 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required. |
| doi_str_mv | 10.3390/ijerph18083926 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8068399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2566040261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-4df676c2b1d62b6e53bbb4d43753589f8a5e62e5b181f66feaa132462fce19403</originalsourceid><addsrcrecordid>eNpdkctLw0AQxhdRfFSvHiXgxYOt-8q4uQjSqi0KQqlel00ysVvTTd1NFP971yfqaQbm933MzEfIPqMDITJ6YhfoV3OmqBIZhzWyzQBoXwJl67_6LbITwoJSoSRkm2QrSqOEwTa5ns0xmWJtWtu4MLerJMf2BdEl48l9Mur8x-A4mbjQ1dZFNNjQGldgYlyZjKyJPIZkasPjLtmoTB1w76v2yN3lxWw47t_cXk2G5zf9QjLV9mVZwSkUPGcl8BwwFXmey1KK01SkKquUSRE4pjlTrAKo0BgmuAReFcgySUWPnH36rrp8iWWBrvWm1itvl8a_6sZY_Xfi7Fw_NM9aUYhvyqLB0ZeBb546DK1e2lBgXRuHTRc0TzlVwFQGET38hy6azrt4XqTieyXlwCI1-KQK34TgsfpZhlH9npP-m1MUHPw-4Qf_Dka8AfYyjx8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2566040261</pqid></control><display><type>article</type><title>The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>PubMed Central Open Access</source><creator>Tiozzo, Eduard ; Rodriguez, Allan ; Konefal, Janet ; Farkas, Gary J ; Maher, Jennifer L ; Lewis, John E</creator><creatorcontrib>Tiozzo, Eduard ; Rodriguez, Allan ; Konefal, Janet ; Farkas, Gary J ; Maher, Jennifer L ; Lewis, John E</creatorcontrib><description>The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (
= 34), those with longer HIV duration (
= 48) were on average older (
= 0.02), reported lower consumption of alcohol (
= 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR,
= 0.02), were also more likely to be a woman (
= 0.06), and have higher levels of fasting insulin (
= 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (
= 0.02 and
= 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18083926</identifier><identifier>PMID: 33918016</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Antiretroviral agents ; Antiretroviral therapy ; Automation ; Biomarkers ; Blood pressure ; Body mass index ; Body weight ; Cholesterol ; Demographics ; Demography ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Dietary intake ; Exercise ; Fasting ; Glucose ; Glucose metabolism ; Health risks ; Hemoglobin ; HIV ; Homeostasis ; Human immunodeficiency virus ; Infections ; Insulin ; Insulin resistance ; Life expectancy ; Lipoproteins ; Long-term effects ; Metabolism ; Variables</subject><ispartof>International journal of environmental research and public health, 2021-04, Vol.18 (8), p.3926</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-4df676c2b1d62b6e53bbb4d43753589f8a5e62e5b181f66feaa132462fce19403</citedby><cites>FETCH-LOGICAL-c418t-4df676c2b1d62b6e53bbb4d43753589f8a5e62e5b181f66feaa132462fce19403</cites><orcidid>0000-0002-5482-6049</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068399/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068399/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33918016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tiozzo, Eduard</creatorcontrib><creatorcontrib>Rodriguez, Allan</creatorcontrib><creatorcontrib>Konefal, Janet</creatorcontrib><creatorcontrib>Farkas, Gary J</creatorcontrib><creatorcontrib>Maher, Jennifer L</creatorcontrib><creatorcontrib>Lewis, John E</creatorcontrib><title>The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (
= 34), those with longer HIV duration (
= 48) were on average older (
= 0.02), reported lower consumption of alcohol (
= 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR,
= 0.02), were also more likely to be a woman (
= 0.06), and have higher levels of fasting insulin (
= 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (
= 0.02 and
= 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.</description><subject>Age</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>Automation</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cholesterol</subject><subject>Demographics</subject><subject>Demography</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Dietary intake</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>HIV</subject><subject>Homeostasis</subject><subject>Human immunodeficiency virus</subject><subject>Infections</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Life expectancy</subject><subject>Lipoproteins</subject><subject>Long-term effects</subject><subject>Metabolism</subject><subject>Variables</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkctLw0AQxhdRfFSvHiXgxYOt-8q4uQjSqi0KQqlel00ysVvTTd1NFP971yfqaQbm933MzEfIPqMDITJ6YhfoV3OmqBIZhzWyzQBoXwJl67_6LbITwoJSoSRkm2QrSqOEwTa5ns0xmWJtWtu4MLerJMf2BdEl48l9Mur8x-A4mbjQ1dZFNNjQGldgYlyZjKyJPIZkasPjLtmoTB1w76v2yN3lxWw47t_cXk2G5zf9QjLV9mVZwSkUPGcl8BwwFXmey1KK01SkKquUSRE4pjlTrAKo0BgmuAReFcgySUWPnH36rrp8iWWBrvWm1itvl8a_6sZY_Xfi7Fw_NM9aUYhvyqLB0ZeBb546DK1e2lBgXRuHTRc0TzlVwFQGET38hy6azrt4XqTieyXlwCI1-KQK34TgsfpZhlH9npP-m1MUHPw-4Qf_Dka8AfYyjx8</recordid><startdate>20210408</startdate><enddate>20210408</enddate><creator>Tiozzo, Eduard</creator><creator>Rodriguez, Allan</creator><creator>Konefal, Janet</creator><creator>Farkas, Gary J</creator><creator>Maher, Jennifer L</creator><creator>Lewis, John E</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5482-6049</orcidid></search><sort><creationdate>20210408</creationdate><title>The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk</title><author>Tiozzo, Eduard ; Rodriguez, Allan ; Konefal, Janet ; Farkas, Gary J ; Maher, Jennifer L ; Lewis, John E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-4df676c2b1d62b6e53bbb4d43753589f8a5e62e5b181f66feaa132462fce19403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral therapy</topic><topic>Automation</topic><topic>Biomarkers</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Cholesterol</topic><topic>Demographics</topic><topic>Demography</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Dietary intake</topic><topic>Exercise</topic><topic>Fasting</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Health risks</topic><topic>Hemoglobin</topic><topic>HIV</topic><topic>Homeostasis</topic><topic>Human immunodeficiency virus</topic><topic>Infections</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Life expectancy</topic><topic>Lipoproteins</topic><topic>Long-term effects</topic><topic>Metabolism</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tiozzo, Eduard</creatorcontrib><creatorcontrib>Rodriguez, Allan</creatorcontrib><creatorcontrib>Konefal, Janet</creatorcontrib><creatorcontrib>Farkas, Gary J</creatorcontrib><creatorcontrib>Maher, Jennifer L</creatorcontrib><creatorcontrib>Lewis, John E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tiozzo, Eduard</au><au>Rodriguez, Allan</au><au>Konefal, Janet</au><au>Farkas, Gary J</au><au>Maher, Jennifer L</au><au>Lewis, John E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2021-04-08</date><risdate>2021</risdate><volume>18</volume><issue>8</issue><spage>3926</spage><pages>3926-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration (
= 34), those with longer HIV duration (
= 48) were on average older (
= 0.02), reported lower consumption of alcohol (
= 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR,
= 0.02), were also more likely to be a woman (
= 0.06), and have higher levels of fasting insulin (
= 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher (
= 0.02 and
= 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33918016</pmid><doi>10.3390/ijerph18083926</doi><orcidid>https://orcid.org/0000-0002-5482-6049</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2021-04, Vol.18 (8), p.3926 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8068399 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Age Antiretroviral agents Antiretroviral therapy Automation Biomarkers Blood pressure Body mass index Body weight Cholesterol Demographics Demography Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dietary intake Exercise Fasting Glucose Glucose metabolism Health risks Hemoglobin HIV Homeostasis Human immunodeficiency virus Infections Insulin Insulin resistance Life expectancy Lipoproteins Long-term effects Metabolism Variables |
| title | The Relationship between HIV Duration, Insulin Resistance and Diabetes Risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A41%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Relationship%20between%20HIV%20Duration,%20Insulin%20Resistance%20and%20Diabetes%20Risk&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Tiozzo,%20Eduard&rft.date=2021-04-08&rft.volume=18&rft.issue=8&rft.spage=3926&rft.pages=3926-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph18083926&rft_dat=%3Cproquest_pubme%3E2566040261%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2566040261&rft_id=info:pmid/33918016&rfr_iscdi=true |