A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial
Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass ind...
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| Veröffentlicht in: | Nutrients 2021-04, Vol.13 (4), p.1220 |
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| creator | Frugé, Andrew D Smith, Kristen S Riviere, Aaron J Tenpenny-Chigas, Rachel Demark-Wahnefried, Wendy Arthur, Anna E Murrah, William M van der Pol, William J Jasper, Shanese L Morrow, Casey D Arnold, Robert D Braxton-Lloyd, Kimberly |
| description | Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass index (BMI) > 30 kg/m
(NCT03582306). Herein, our objective was to report a priori secondary outcomes. Participants were recruited and enrolled in 2018, stratified by gender, and randomized to two arms: immediate intervention group (IG, n = 26) or delayed intervention group (DG, n = 24). During the 4 week intervention period, participants were provided with frozen GLV and counseled to consume 1 cooked cup equivalent daily. Participants consumed their normal diet for the remaining 8 weeks. At each of four study visits, anthropometrics, stool, and blood were taken. Overall, plasma Vitamin K1 (0.50 ± 1.18 ng/mL,
< 0.001) increased, while circulating 8OHdG (-8.52 ± 19.05 ng/mL,
< 0.001), fecal 8OHdG (-6.78 ± 34.86 ng/mL,
< 0.001), and TNFα (-16.95 ± 60.82 pg/mL,
< 0.001) decreased during the GLV intervention compared to control periods. Alpha diversity of fecal microbiota and relative abundance of major taxa did not differ systematically across study periods. Further investigation of the effects of increased GLV intake on CRC risk is warranted. |
| doi_str_mv | 10.3390/nu13041220 |
| format | Article |
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(NCT03582306). Herein, our objective was to report a priori secondary outcomes. Participants were recruited and enrolled in 2018, stratified by gender, and randomized to two arms: immediate intervention group (IG, n = 26) or delayed intervention group (DG, n = 24). During the 4 week intervention period, participants were provided with frozen GLV and counseled to consume 1 cooked cup equivalent daily. Participants consumed their normal diet for the remaining 8 weeks. At each of four study visits, anthropometrics, stool, and blood were taken. Overall, plasma Vitamin K1 (0.50 ± 1.18 ng/mL,
< 0.001) increased, while circulating 8OHdG (-8.52 ± 19.05 ng/mL,
< 0.001), fecal 8OHdG (-6.78 ± 34.86 ng/mL,
< 0.001), and TNFα (-16.95 ± 60.82 pg/mL,
< 0.001) decreased during the GLV intervention compared to control periods. Alpha diversity of fecal microbiota and relative abundance of major taxa did not differ systematically across study periods. Further investigation of the effects of increased GLV intake on CRC risk is warranted.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13041220</identifier><identifier>PMID: 33917165</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Body composition ; Body mass ; Body mass index ; Body size ; Chlorophyll ; Colorectal cancer ; Colorectal carcinoma ; Data collection ; Deoxyribonucleic acid ; Diet ; DNA ; DNA damage ; Feasibility ; Fecal microflora ; Feces ; Health risks ; Immunoglobulins ; Intervention ; Meat ; Medical prognosis ; Medical research ; Microbiota ; Mortality ; Questionnaires ; Relative abundance ; Risk ; Risk reduction ; Tumor necrosis factor-α ; Vegetables</subject><ispartof>Nutrients, 2021-04, Vol.13 (4), p.1220</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-a06ca710ab6c06028a08fe7ddc3f10036a0139f910830c904901bcd3abefba4c3</citedby><cites>FETCH-LOGICAL-c406t-a06ca710ab6c06028a08fe7ddc3f10036a0139f910830c904901bcd3abefba4c3</cites><orcidid>0000-0001-9119-1380 ; 0000-0001-6143-3991 ; 0000-0002-5208-4336 ; 0000-0002-8845-0609 ; 0000-0003-1063-6494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067874/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067874/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33917165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frugé, Andrew D</creatorcontrib><creatorcontrib>Smith, Kristen S</creatorcontrib><creatorcontrib>Riviere, Aaron J</creatorcontrib><creatorcontrib>Tenpenny-Chigas, Rachel</creatorcontrib><creatorcontrib>Demark-Wahnefried, Wendy</creatorcontrib><creatorcontrib>Arthur, Anna E</creatorcontrib><creatorcontrib>Murrah, William M</creatorcontrib><creatorcontrib>van der Pol, William J</creatorcontrib><creatorcontrib>Jasper, Shanese L</creatorcontrib><creatorcontrib>Morrow, Casey D</creatorcontrib><creatorcontrib>Arnold, Robert D</creatorcontrib><creatorcontrib>Braxton-Lloyd, Kimberly</creatorcontrib><title>A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass index (BMI) > 30 kg/m
(NCT03582306). Herein, our objective was to report a priori secondary outcomes. Participants were recruited and enrolled in 2018, stratified by gender, and randomized to two arms: immediate intervention group (IG, n = 26) or delayed intervention group (DG, n = 24). During the 4 week intervention period, participants were provided with frozen GLV and counseled to consume 1 cooked cup equivalent daily. Participants consumed their normal diet for the remaining 8 weeks. At each of four study visits, anthropometrics, stool, and blood were taken. Overall, plasma Vitamin K1 (0.50 ± 1.18 ng/mL,
< 0.001) increased, while circulating 8OHdG (-8.52 ± 19.05 ng/mL,
< 0.001), fecal 8OHdG (-6.78 ± 34.86 ng/mL,
< 0.001), and TNFα (-16.95 ± 60.82 pg/mL,
< 0.001) decreased during the GLV intervention compared to control periods. Alpha diversity of fecal microbiota and relative abundance of major taxa did not differ systematically across study periods. 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Smith, Kristen S ; Riviere, Aaron J ; Tenpenny-Chigas, Rachel ; Demark-Wahnefried, Wendy ; Arthur, Anna E ; Murrah, William M ; van der Pol, William J ; Jasper, Shanese L ; Morrow, Casey D ; Arnold, Robert D ; Braxton-Lloyd, Kimberly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-a06ca710ab6c06028a08fe7ddc3f10036a0139f910830c904901bcd3abefba4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adults</topic><topic>Body composition</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Chlorophyll</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Data collection</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Feasibility</topic><topic>Fecal microflora</topic><topic>Feces</topic><topic>Health risks</topic><topic>Immunoglobulins</topic><topic>Intervention</topic><topic>Meat</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Microbiota</topic><topic>Mortality</topic><topic>Questionnaires</topic><topic>Relative abundance</topic><topic>Risk</topic><topic>Risk reduction</topic><topic>Tumor necrosis factor-α</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frugé, Andrew D</creatorcontrib><creatorcontrib>Smith, Kristen S</creatorcontrib><creatorcontrib>Riviere, Aaron J</creatorcontrib><creatorcontrib>Tenpenny-Chigas, Rachel</creatorcontrib><creatorcontrib>Demark-Wahnefried, Wendy</creatorcontrib><creatorcontrib>Arthur, Anna E</creatorcontrib><creatorcontrib>Murrah, William M</creatorcontrib><creatorcontrib>van der Pol, William J</creatorcontrib><creatorcontrib>Jasper, Shanese L</creatorcontrib><creatorcontrib>Morrow, Casey D</creatorcontrib><creatorcontrib>Arnold, Robert D</creatorcontrib><creatorcontrib>Braxton-Lloyd, Kimberly</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frugé, Andrew D</au><au>Smith, Kristen S</au><au>Riviere, Aaron J</au><au>Tenpenny-Chigas, Rachel</au><au>Demark-Wahnefried, Wendy</au><au>Arthur, Anna E</au><au>Murrah, William M</au><au>van der Pol, William J</au><au>Jasper, Shanese L</au><au>Morrow, Casey D</au><au>Arnold, Robert D</au><au>Braxton-Lloyd, Kimberly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2021-04-07</date><risdate>2021</risdate><volume>13</volume><issue>4</issue><spage>1220</spage><pages>1220-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass index (BMI) > 30 kg/m
(NCT03582306). Herein, our objective was to report a priori secondary outcomes. Participants were recruited and enrolled in 2018, stratified by gender, and randomized to two arms: immediate intervention group (IG, n = 26) or delayed intervention group (DG, n = 24). During the 4 week intervention period, participants were provided with frozen GLV and counseled to consume 1 cooked cup equivalent daily. Participants consumed their normal diet for the remaining 8 weeks. At each of four study visits, anthropometrics, stool, and blood were taken. Overall, plasma Vitamin K1 (0.50 ± 1.18 ng/mL,
< 0.001) increased, while circulating 8OHdG (-8.52 ± 19.05 ng/mL,
< 0.001), fecal 8OHdG (-6.78 ± 34.86 ng/mL,
< 0.001), and TNFα (-16.95 ± 60.82 pg/mL,
< 0.001) decreased during the GLV intervention compared to control periods. Alpha diversity of fecal microbiota and relative abundance of major taxa did not differ systematically across study periods. Further investigation of the effects of increased GLV intake on CRC risk is warranted.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33917165</pmid><doi>10.3390/nu13041220</doi><orcidid>https://orcid.org/0000-0001-9119-1380</orcidid><orcidid>https://orcid.org/0000-0001-6143-3991</orcidid><orcidid>https://orcid.org/0000-0002-5208-4336</orcidid><orcidid>https://orcid.org/0000-0002-8845-0609</orcidid><orcidid>https://orcid.org/0000-0003-1063-6494</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adults Body composition Body mass Body mass index Body size Chlorophyll Colorectal cancer Colorectal carcinoma Data collection Deoxyribonucleic acid Diet DNA DNA damage Feasibility Fecal microflora Feces Health risks Immunoglobulins Intervention Meat Medical prognosis Medical research Microbiota Mortality Questionnaires Relative abundance Risk Risk reduction Tumor necrosis factor-α Vegetables |
| title | A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial |
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