Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan
Coagulation disorder is a major cause of death in sepsis patients. Recently, sepsis-induced coagulopathy (SIC) scoring was developed as a new criterion for coagulopathy-associated sepsis. We aimed to evaluate the accuracy of the SIC score for predicting the prognosis of septic shock. We analyzed dat...
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| Veröffentlicht in: | International journal of hematology 2021-08, Vol.114 (2), p.164-171 |
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| creator | Tanaka, Chie Tagami, Takashi Kudo, Saori Takehara, Akiko Fukuda, Reo Nakayama, Fumihiko Kaneko, Junya Ishiki, Yoshito Sato, Shin Kuno, Masamune Unemoto, Kyoko |
| description | Coagulation disorder is a major cause of death in sepsis patients. Recently, sepsis-induced coagulopathy (SIC) scoring was developed as a new criterion for coagulopathy-associated sepsis. We aimed to evaluate the accuracy of the SIC score for predicting the prognosis of septic shock. We analyzed data from a multicenter observational study conducted from 2011 to 2013. We grouped the participants into those who did and did not use vasopressors, and compared the in-hospital mortality rates of SIC and non-SIC patients. Patients who needed vasopressors were considered to have septic shock. We performed survival analysis adjusted by factors independently associated with mortality. SIC developed in 66.4% of patients who used vasopressors and 42.2% of patients who did not. The in-hospital mortality difference between the SIC and non-SIC groups was statistically significant in those who needed vasopressors (35.8% vs 27.9%,
p
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| doi_str_mv | 10.1007/s12185-021-03152-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8067778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2554130757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-f57bb1efb1d651e288b4b200e3455fa22d662010c6f55265ffde5aca63968eb3</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhS0EokPhBVggS2zYGGwnjh0WSKgqf6rEpmJr3TjOjIvHDnbSKm_Ux8SZKeVnwcqWznfPvdc-CD1n9DWjVL7JjDMlCOWM0IoJTuoHaMNUI0glZf0QbWjLBRGS0RP0JOcrSpmktXyMTqpKtaJt1AbdfgPvephcDDgOONsxu0xc6Gdje2wibGcfR5h2C84mJotdwCa5yRnwfsHOe1xUZ8OU8Y2bdqtDEXHeRfP9LR5jnnC5Ygjgl2K9NgEcDg1vXG_xfvaFL_U24dhlm64PGnicp7lf1n5fYITwFD0awGf77O48RZcfzi_PPpGLrx8_n72_IKZu1UQGIbuO2aFjfSOY5Up1dccptVUtxACc903DKaOmGYTgjRiG3gow0FTlOWxXnaJ3R9tx7va2XwdL4PWY3B7SoiM4_bcS3E5v47VWtJFSqmLw6s4gxR-zzZPeu2ys9xBsnLPmgilZM6Hagr78B72Kcyqrr5SoWUWlkIXiR8qkmHOyw_0wjOo1B_qYA11yoA850HUpevHnGvclvz6-ANURyEUKW5t-9_6P7U8gmcOJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2554130757</pqid></control><display><type>article</type><title>Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Tanaka, Chie ; Tagami, Takashi ; Kudo, Saori ; Takehara, Akiko ; Fukuda, Reo ; Nakayama, Fumihiko ; Kaneko, Junya ; Ishiki, Yoshito ; Sato, Shin ; Kuno, Masamune ; Unemoto, Kyoko</creator><creatorcontrib>Tanaka, Chie ; Tagami, Takashi ; Kudo, Saori ; Takehara, Akiko ; Fukuda, Reo ; Nakayama, Fumihiko ; Kaneko, Junya ; Ishiki, Yoshito ; Sato, Shin ; Kuno, Masamune ; Unemoto, Kyoko</creatorcontrib><description>Coagulation disorder is a major cause of death in sepsis patients. Recently, sepsis-induced coagulopathy (SIC) scoring was developed as a new criterion for coagulopathy-associated sepsis. We aimed to evaluate the accuracy of the SIC score for predicting the prognosis of septic shock. We analyzed data from a multicenter observational study conducted from 2011 to 2013. We grouped the participants into those who did and did not use vasopressors, and compared the in-hospital mortality rates of SIC and non-SIC patients. Patients who needed vasopressors were considered to have septic shock. We performed survival analysis adjusted by factors independently associated with mortality. SIC developed in 66.4% of patients who used vasopressors and 42.2% of patients who did not. The in-hospital mortality difference between the SIC and non-SIC groups was statistically significant in those who needed vasopressors (35.8% vs 27.9%,
p
< 0.01). Cox regression analysis indicated that SIC was significantly correlated with mortality risk in patients who used vasopressors (hazard ratio [HR] 1.39; 95% confidence interval [CI] 1.13–1.70;
p
< 0.01), but not in those who did not (HR 1.38; 95% CI 0.81–2.34;
p
= 0.23). In conclusion, the SIC score might be a good diagnostic indicator of fatal coagulopathy among sepsis patients who need vasopressors.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-021-03152-4</identifier><identifier>PMID: 33895968</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers ; Blood Coagulation ; Blood Coagulation Disorders - blood ; Blood Coagulation Disorders - diagnosis ; Blood Coagulation Disorders - etiology ; Blood Coagulation Tests ; Coagulation ; Confidence intervals ; Critical Illness ; Female ; Hematology ; Humans ; Japan ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Observational studies ; Oncology ; Original ; Original Article ; Patients ; Platelet Count ; Prognosis ; Proportional Hazards Models ; Regression analysis ; Sepsis ; Sepsis - blood ; Sepsis - complications ; Sepsis - diagnosis ; Sepsis - mortality ; Septic shock ; Shock, Septic - blood ; Shock, Septic - complications ; Shock, Septic - diagnosis ; Shock, Septic - mortality ; Statistical analysis ; Survival analysis</subject><ispartof>International journal of hematology, 2021-08, Vol.114 (2), p.164-171</ispartof><rights>Japanese Society of Hematology 2021</rights><rights>2021. Japanese Society of Hematology.</rights><rights>Japanese Society of Hematology 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-f57bb1efb1d651e288b4b200e3455fa22d662010c6f55265ffde5aca63968eb3</citedby><cites>FETCH-LOGICAL-c498t-f57bb1efb1d651e288b4b200e3455fa22d662010c6f55265ffde5aca63968eb3</cites><orcidid>0000-0001-6953-1932</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-021-03152-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-021-03152-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33895968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Chie</creatorcontrib><creatorcontrib>Tagami, Takashi</creatorcontrib><creatorcontrib>Kudo, Saori</creatorcontrib><creatorcontrib>Takehara, Akiko</creatorcontrib><creatorcontrib>Fukuda, Reo</creatorcontrib><creatorcontrib>Nakayama, Fumihiko</creatorcontrib><creatorcontrib>Kaneko, Junya</creatorcontrib><creatorcontrib>Ishiki, Yoshito</creatorcontrib><creatorcontrib>Sato, Shin</creatorcontrib><creatorcontrib>Kuno, Masamune</creatorcontrib><creatorcontrib>Unemoto, Kyoko</creatorcontrib><title>Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Coagulation disorder is a major cause of death in sepsis patients. Recently, sepsis-induced coagulopathy (SIC) scoring was developed as a new criterion for coagulopathy-associated sepsis. We aimed to evaluate the accuracy of the SIC score for predicting the prognosis of septic shock. We analyzed data from a multicenter observational study conducted from 2011 to 2013. We grouped the participants into those who did and did not use vasopressors, and compared the in-hospital mortality rates of SIC and non-SIC patients. Patients who needed vasopressors were considered to have septic shock. We performed survival analysis adjusted by factors independently associated with mortality. SIC developed in 66.4% of patients who used vasopressors and 42.2% of patients who did not. The in-hospital mortality difference between the SIC and non-SIC groups was statistically significant in those who needed vasopressors (35.8% vs 27.9%,
p
< 0.01). Cox regression analysis indicated that SIC was significantly correlated with mortality risk in patients who used vasopressors (hazard ratio [HR] 1.39; 95% confidence interval [CI] 1.13–1.70;
p
< 0.01), but not in those who did not (HR 1.38; 95% CI 0.81–2.34;
p
= 0.23). In conclusion, the SIC score might be a good diagnostic indicator of fatal coagulopathy among sepsis patients who need vasopressors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Blood Coagulation</subject><subject>Blood Coagulation Disorders - blood</subject><subject>Blood Coagulation Disorders - diagnosis</subject><subject>Blood Coagulation Disorders - etiology</subject><subject>Blood Coagulation Tests</subject><subject>Coagulation</subject><subject>Confidence intervals</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Regression analysis</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - complications</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - mortality</subject><subject>Septic shock</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - complications</subject><subject>Shock, Septic - diagnosis</subject><subject>Shock, Septic - mortality</subject><subject>Statistical analysis</subject><subject>Survival analysis</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks1u1DAUhS0EokPhBVggS2zYGGwnjh0WSKgqf6rEpmJr3TjOjIvHDnbSKm_Ux8SZKeVnwcqWznfPvdc-CD1n9DWjVL7JjDMlCOWM0IoJTuoHaMNUI0glZf0QbWjLBRGS0RP0JOcrSpmktXyMTqpKtaJt1AbdfgPvephcDDgOONsxu0xc6Gdje2wibGcfR5h2C84mJotdwCa5yRnwfsHOe1xUZ8OU8Y2bdqtDEXHeRfP9LR5jnnC5Ygjgl2K9NgEcDg1vXG_xfvaFL_U24dhlm64PGnicp7lf1n5fYITwFD0awGf77O48RZcfzi_PPpGLrx8_n72_IKZu1UQGIbuO2aFjfSOY5Up1dccptVUtxACc903DKaOmGYTgjRiG3gow0FTlOWxXnaJ3R9tx7va2XwdL4PWY3B7SoiM4_bcS3E5v47VWtJFSqmLw6s4gxR-zzZPeu2ys9xBsnLPmgilZM6Hagr78B72Kcyqrr5SoWUWlkIXiR8qkmHOyw_0wjOo1B_qYA11yoA850HUpevHnGvclvz6-ANURyEUKW5t-9_6P7U8gmcOJ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Tanaka, Chie</creator><creator>Tagami, Takashi</creator><creator>Kudo, Saori</creator><creator>Takehara, Akiko</creator><creator>Fukuda, Reo</creator><creator>Nakayama, Fumihiko</creator><creator>Kaneko, Junya</creator><creator>Ishiki, Yoshito</creator><creator>Sato, Shin</creator><creator>Kuno, Masamune</creator><creator>Unemoto, Kyoko</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6953-1932</orcidid></search><sort><creationdate>20210801</creationdate><title>Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan</title><author>Tanaka, Chie ; Tagami, Takashi ; Kudo, Saori ; Takehara, Akiko ; Fukuda, Reo ; Nakayama, Fumihiko ; Kaneko, Junya ; Ishiki, Yoshito ; Sato, Shin ; Kuno, Masamune ; Unemoto, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-f57bb1efb1d651e288b4b200e3455fa22d662010c6f55265ffde5aca63968eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Blood Coagulation</topic><topic>Blood Coagulation Disorders - blood</topic><topic>Blood Coagulation Disorders - diagnosis</topic><topic>Blood Coagulation Disorders - etiology</topic><topic>Blood Coagulation Tests</topic><topic>Coagulation</topic><topic>Confidence intervals</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Observational studies</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Platelet Count</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Regression analysis</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - complications</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - mortality</topic><topic>Septic shock</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - complications</topic><topic>Shock, Septic - diagnosis</topic><topic>Shock, Septic - mortality</topic><topic>Statistical analysis</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Chie</creatorcontrib><creatorcontrib>Tagami, Takashi</creatorcontrib><creatorcontrib>Kudo, Saori</creatorcontrib><creatorcontrib>Takehara, Akiko</creatorcontrib><creatorcontrib>Fukuda, Reo</creatorcontrib><creatorcontrib>Nakayama, Fumihiko</creatorcontrib><creatorcontrib>Kaneko, Junya</creatorcontrib><creatorcontrib>Ishiki, Yoshito</creatorcontrib><creatorcontrib>Sato, Shin</creatorcontrib><creatorcontrib>Kuno, Masamune</creatorcontrib><creatorcontrib>Unemoto, Kyoko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Chie</au><au>Tagami, Takashi</au><au>Kudo, Saori</au><au>Takehara, Akiko</au><au>Fukuda, Reo</au><au>Nakayama, Fumihiko</au><au>Kaneko, Junya</au><au>Ishiki, Yoshito</au><au>Sato, Shin</au><au>Kuno, Masamune</au><au>Unemoto, Kyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>114</volume><issue>2</issue><spage>164</spage><epage>171</epage><pages>164-171</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Coagulation disorder is a major cause of death in sepsis patients. Recently, sepsis-induced coagulopathy (SIC) scoring was developed as a new criterion for coagulopathy-associated sepsis. We aimed to evaluate the accuracy of the SIC score for predicting the prognosis of septic shock. We analyzed data from a multicenter observational study conducted from 2011 to 2013. We grouped the participants into those who did and did not use vasopressors, and compared the in-hospital mortality rates of SIC and non-SIC patients. Patients who needed vasopressors were considered to have septic shock. We performed survival analysis adjusted by factors independently associated with mortality. SIC developed in 66.4% of patients who used vasopressors and 42.2% of patients who did not. The in-hospital mortality difference between the SIC and non-SIC groups was statistically significant in those who needed vasopressors (35.8% vs 27.9%,
p
< 0.01). Cox regression analysis indicated that SIC was significantly correlated with mortality risk in patients who used vasopressors (hazard ratio [HR] 1.39; 95% confidence interval [CI] 1.13–1.70;
p
< 0.01), but not in those who did not (HR 1.38; 95% CI 0.81–2.34;
p
= 0.23). In conclusion, the SIC score might be a good diagnostic indicator of fatal coagulopathy among sepsis patients who need vasopressors.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>33895968</pmid><doi>10.1007/s12185-021-03152-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6953-1932</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarkers Blood Coagulation Blood Coagulation Disorders - blood Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - etiology Blood Coagulation Tests Coagulation Confidence intervals Critical Illness Female Hematology Humans Japan Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mortality Observational studies Oncology Original Original Article Patients Platelet Count Prognosis Proportional Hazards Models Regression analysis Sepsis Sepsis - blood Sepsis - complications Sepsis - diagnosis Sepsis - mortality Septic shock Shock, Septic - blood Shock, Septic - complications Shock, Septic - diagnosis Shock, Septic - mortality Statistical analysis Survival analysis |
| title | Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan |
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