Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress
Refugees from war zones often have missing significant others. A loss without confirmation is described as an ambiguous loss. This physical absence with simultaneous mental persistence can be accompanied by economic, social or legal problems, boundary ambiguity (i.e., uncertainty about who belongs t...
Gespeichert in:
Veröffentlicht in: | International journal of environmental research and public health 2021-04, Vol.18 (8), p.3865 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 8 |
container_start_page | 3865 |
container_title | International journal of environmental research and public health |
container_volume | 18 |
creator | Renner, Anna Jäckle, David Nagl, Michaela Plexnies, Anna Röhr, Susanne Löbner, Margrit Grochtdreis, Thomas Dams, Judith König, Hans-Helmut Riedel-Heller, Steffi Kersting, Anette |
description | Refugees from war zones often have missing significant others. A loss without confirmation is described as an ambiguous loss. This physical absence with simultaneous mental persistence can be accompanied by economic, social or legal problems, boundary ambiguity (i.e., uncertainty about who belongs to the family system), and can have a negative impact on mental health. The aim of this study was to identify sociodemographic and loss-related predictors for prolonged grief, anxiety, depression, post-traumatic stress disorder (PTSD) and somatization in treatment-seeking Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. For the present study, data were based on the treatment-seeking baseline sample of the "Sanadak" randomized-controlled trial, analyzing a subsample of 47 Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. Sociodemographic and loss-related questions were applied, along with standardized instruments for symptoms of prolonged grief (ICG), anxiety (GAD-7), depression (PHQ-9), PTSD (PDS-5) and somatization (PHQ-15). Linear regression models were used to predict mental health outcomes. Having lost a close family member and higher boundary ambiguity showed a statistically significant association with higher severity in prolonged grief. The overall model for somatization reached statistical significance, while no predictor independently did. Boundary ambiguity showed a statistically significant positive association with depression, while the overall model showed no statistically significant associations. Boundary ambiguity and missing family members seemed to be important predictors for prolonged grief. These findings support the importance of reunification programs and suggest an inclusion of the topic into psychosocial support structures, e.g., including psychoeducational elements on boundary ambiguity in support groups for traumatized individuals and families experiencing ambiguous loss. Further research is needed for a more detailed understanding of the impact of ambiguous loss on refugee populations. |
doi_str_mv | 10.3390/ijerph18083865 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8067706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2566046893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-1c5aef730461c9897088d8d84cd81e14046a0bda7a368fc75420611059efc3e13</originalsourceid><addsrcrecordid>eNpdkUlPwzAQhS0EomW5ckSWuHBJGdeJ43BAQuxSWcRytlxn0rrKUuwEVH49RgVUkA-27G-e580jZI_BgPMMjuwM3XzKJEguRbJG-kwIiGIBbH3l3CNb3s8AuIxFtkl6oZSlkMg-uXt2uqt0az8wp08LZ3VNH7HoJoievtt2Sk-rsZ10TefpqPH-mD44zK1pG-dpU9BbrFtd0nPrW4fe75CNQpced7_3bfJyefF8dh2N7q9uzk5HkYmZbCNmEo1FyiEWzGQyS0HKPKzY5JIhi8O9hnGuU82FLEyaxEMQjEGSYWE4Mr5NTpa6825cYW5CF06Xau5spd1CNdqqvy-1napJ86YkiDQFEQQOvwVc89qhb1VlvcGy1DUGr2qYDEEmmeRffx38Q2dN5-pgL1BhwrGQGQ_UYEkZF8bksPhthoH6ikr9jSoU7K9a-MV_suGfiAeQjA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2566046893</pqid></control><display><type>article</type><title>Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Renner, Anna ; Jäckle, David ; Nagl, Michaela ; Plexnies, Anna ; Röhr, Susanne ; Löbner, Margrit ; Grochtdreis, Thomas ; Dams, Judith ; König, Hans-Helmut ; Riedel-Heller, Steffi ; Kersting, Anette</creator><creatorcontrib>Renner, Anna ; Jäckle, David ; Nagl, Michaela ; Plexnies, Anna ; Röhr, Susanne ; Löbner, Margrit ; Grochtdreis, Thomas ; Dams, Judith ; König, Hans-Helmut ; Riedel-Heller, Steffi ; Kersting, Anette</creatorcontrib><description>Refugees from war zones often have missing significant others. A loss without confirmation is described as an ambiguous loss. This physical absence with simultaneous mental persistence can be accompanied by economic, social or legal problems, boundary ambiguity (i.e., uncertainty about who belongs to the family system), and can have a negative impact on mental health. The aim of this study was to identify sociodemographic and loss-related predictors for prolonged grief, anxiety, depression, post-traumatic stress disorder (PTSD) and somatization in treatment-seeking Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. For the present study, data were based on the treatment-seeking baseline sample of the "Sanadak" randomized-controlled trial, analyzing a subsample of 47 Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. Sociodemographic and loss-related questions were applied, along with standardized instruments for symptoms of prolonged grief (ICG), anxiety (GAD-7), depression (PHQ-9), PTSD (PDS-5) and somatization (PHQ-15). Linear regression models were used to predict mental health outcomes. Having lost a close family member and higher boundary ambiguity showed a statistically significant association with higher severity in prolonged grief. The overall model for somatization reached statistical significance, while no predictor independently did. Boundary ambiguity showed a statistically significant positive association with depression, while the overall model showed no statistically significant associations. Boundary ambiguity and missing family members seemed to be important predictors for prolonged grief. These findings support the importance of reunification programs and suggest an inclusion of the topic into psychosocial support structures, e.g., including psychoeducational elements on boundary ambiguity in support groups for traumatized individuals and families experiencing ambiguous loss. Further research is needed for a more detailed understanding of the impact of ambiguous loss on refugee populations.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18083865</identifier><identifier>PMID: 33917058</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ambiguity ; Anxiety ; Coping ; Grief ; Mathematical models ; Mental depression ; Mental disorders ; Mental health ; Murders & murder attempts ; Post traumatic stress disorder ; Psychological stress ; Psychopathology ; Questionnaires ; Refugees ; Regression analysis ; Statistical analysis</subject><ispartof>International journal of environmental research and public health, 2021-04, Vol.18 (8), p.3865</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-1c5aef730461c9897088d8d84cd81e14046a0bda7a368fc75420611059efc3e13</citedby><cites>FETCH-LOGICAL-c418t-1c5aef730461c9897088d8d84cd81e14046a0bda7a368fc75420611059efc3e13</cites><orcidid>0000-0001-9385-0669 ; 0000-0001-5711-6862 ; 0000-0002-9115-0674 ; 0000-0002-0176-7989 ; 0000-0002-0481-0989 ; 0000-0001-5984-8127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067706/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067706/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33917058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renner, Anna</creatorcontrib><creatorcontrib>Jäckle, David</creatorcontrib><creatorcontrib>Nagl, Michaela</creatorcontrib><creatorcontrib>Plexnies, Anna</creatorcontrib><creatorcontrib>Röhr, Susanne</creatorcontrib><creatorcontrib>Löbner, Margrit</creatorcontrib><creatorcontrib>Grochtdreis, Thomas</creatorcontrib><creatorcontrib>Dams, Judith</creatorcontrib><creatorcontrib>König, Hans-Helmut</creatorcontrib><creatorcontrib>Riedel-Heller, Steffi</creatorcontrib><creatorcontrib>Kersting, Anette</creatorcontrib><title>Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Refugees from war zones often have missing significant others. A loss without confirmation is described as an ambiguous loss. This physical absence with simultaneous mental persistence can be accompanied by economic, social or legal problems, boundary ambiguity (i.e., uncertainty about who belongs to the family system), and can have a negative impact on mental health. The aim of this study was to identify sociodemographic and loss-related predictors for prolonged grief, anxiety, depression, post-traumatic stress disorder (PTSD) and somatization in treatment-seeking Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. For the present study, data were based on the treatment-seeking baseline sample of the "Sanadak" randomized-controlled trial, analyzing a subsample of 47 Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. Sociodemographic and loss-related questions were applied, along with standardized instruments for symptoms of prolonged grief (ICG), anxiety (GAD-7), depression (PHQ-9), PTSD (PDS-5) and somatization (PHQ-15). Linear regression models were used to predict mental health outcomes. Having lost a close family member and higher boundary ambiguity showed a statistically significant association with higher severity in prolonged grief. The overall model for somatization reached statistical significance, while no predictor independently did. Boundary ambiguity showed a statistically significant positive association with depression, while the overall model showed no statistically significant associations. Boundary ambiguity and missing family members seemed to be important predictors for prolonged grief. These findings support the importance of reunification programs and suggest an inclusion of the topic into psychosocial support structures, e.g., including psychoeducational elements on boundary ambiguity in support groups for traumatized individuals and families experiencing ambiguous loss. Further research is needed for a more detailed understanding of the impact of ambiguous loss on refugee populations.</description><subject>Ambiguity</subject><subject>Anxiety</subject><subject>Coping</subject><subject>Grief</subject><subject>Mathematical models</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Murders & murder attempts</subject><subject>Post traumatic stress disorder</subject><subject>Psychological stress</subject><subject>Psychopathology</subject><subject>Questionnaires</subject><subject>Refugees</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUlPwzAQhS0EomW5ckSWuHBJGdeJ43BAQuxSWcRytlxn0rrKUuwEVH49RgVUkA-27G-e580jZI_BgPMMjuwM3XzKJEguRbJG-kwIiGIBbH3l3CNb3s8AuIxFtkl6oZSlkMg-uXt2uqt0az8wp08LZ3VNH7HoJoievtt2Sk-rsZ10TefpqPH-mD44zK1pG-dpU9BbrFtd0nPrW4fe75CNQpced7_3bfJyefF8dh2N7q9uzk5HkYmZbCNmEo1FyiEWzGQyS0HKPKzY5JIhi8O9hnGuU82FLEyaxEMQjEGSYWE4Mr5NTpa6825cYW5CF06Xau5spd1CNdqqvy-1napJ86YkiDQFEQQOvwVc89qhb1VlvcGy1DUGr2qYDEEmmeRffx38Q2dN5-pgL1BhwrGQGQ_UYEkZF8bksPhthoH6ikr9jSoU7K9a-MV_suGfiAeQjA</recordid><startdate>20210407</startdate><enddate>20210407</enddate><creator>Renner, Anna</creator><creator>Jäckle, David</creator><creator>Nagl, Michaela</creator><creator>Plexnies, Anna</creator><creator>Röhr, Susanne</creator><creator>Löbner, Margrit</creator><creator>Grochtdreis, Thomas</creator><creator>Dams, Judith</creator><creator>König, Hans-Helmut</creator><creator>Riedel-Heller, Steffi</creator><creator>Kersting, Anette</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9385-0669</orcidid><orcidid>https://orcid.org/0000-0001-5711-6862</orcidid><orcidid>https://orcid.org/0000-0002-9115-0674</orcidid><orcidid>https://orcid.org/0000-0002-0176-7989</orcidid><orcidid>https://orcid.org/0000-0002-0481-0989</orcidid><orcidid>https://orcid.org/0000-0001-5984-8127</orcidid></search><sort><creationdate>20210407</creationdate><title>Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress</title><author>Renner, Anna ; Jäckle, David ; Nagl, Michaela ; Plexnies, Anna ; Röhr, Susanne ; Löbner, Margrit ; Grochtdreis, Thomas ; Dams, Judith ; König, Hans-Helmut ; Riedel-Heller, Steffi ; Kersting, Anette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1c5aef730461c9897088d8d84cd81e14046a0bda7a368fc75420611059efc3e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ambiguity</topic><topic>Anxiety</topic><topic>Coping</topic><topic>Grief</topic><topic>Mathematical models</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Murders & murder attempts</topic><topic>Post traumatic stress disorder</topic><topic>Psychological stress</topic><topic>Psychopathology</topic><topic>Questionnaires</topic><topic>Refugees</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renner, Anna</creatorcontrib><creatorcontrib>Jäckle, David</creatorcontrib><creatorcontrib>Nagl, Michaela</creatorcontrib><creatorcontrib>Plexnies, Anna</creatorcontrib><creatorcontrib>Röhr, Susanne</creatorcontrib><creatorcontrib>Löbner, Margrit</creatorcontrib><creatorcontrib>Grochtdreis, Thomas</creatorcontrib><creatorcontrib>Dams, Judith</creatorcontrib><creatorcontrib>König, Hans-Helmut</creatorcontrib><creatorcontrib>Riedel-Heller, Steffi</creatorcontrib><creatorcontrib>Kersting, Anette</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renner, Anna</au><au>Jäckle, David</au><au>Nagl, Michaela</au><au>Plexnies, Anna</au><au>Röhr, Susanne</au><au>Löbner, Margrit</au><au>Grochtdreis, Thomas</au><au>Dams, Judith</au><au>König, Hans-Helmut</au><au>Riedel-Heller, Steffi</au><au>Kersting, Anette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2021-04-07</date><risdate>2021</risdate><volume>18</volume><issue>8</issue><spage>3865</spage><pages>3865-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Refugees from war zones often have missing significant others. A loss without confirmation is described as an ambiguous loss. This physical absence with simultaneous mental persistence can be accompanied by economic, social or legal problems, boundary ambiguity (i.e., uncertainty about who belongs to the family system), and can have a negative impact on mental health. The aim of this study was to identify sociodemographic and loss-related predictors for prolonged grief, anxiety, depression, post-traumatic stress disorder (PTSD) and somatization in treatment-seeking Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. For the present study, data were based on the treatment-seeking baseline sample of the "Sanadak" randomized-controlled trial, analyzing a subsample of 47 Syrian refugees with post-traumatic stress symptoms in Germany experiencing ambiguous loss. Sociodemographic and loss-related questions were applied, along with standardized instruments for symptoms of prolonged grief (ICG), anxiety (GAD-7), depression (PHQ-9), PTSD (PDS-5) and somatization (PHQ-15). Linear regression models were used to predict mental health outcomes. Having lost a close family member and higher boundary ambiguity showed a statistically significant association with higher severity in prolonged grief. The overall model for somatization reached statistical significance, while no predictor independently did. Boundary ambiguity showed a statistically significant positive association with depression, while the overall model showed no statistically significant associations. Boundary ambiguity and missing family members seemed to be important predictors for prolonged grief. These findings support the importance of reunification programs and suggest an inclusion of the topic into psychosocial support structures, e.g., including psychoeducational elements on boundary ambiguity in support groups for traumatized individuals and families experiencing ambiguous loss. Further research is needed for a more detailed understanding of the impact of ambiguous loss on refugee populations.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33917058</pmid><doi>10.3390/ijerph18083865</doi><orcidid>https://orcid.org/0000-0001-9385-0669</orcidid><orcidid>https://orcid.org/0000-0001-5711-6862</orcidid><orcidid>https://orcid.org/0000-0002-9115-0674</orcidid><orcidid>https://orcid.org/0000-0002-0176-7989</orcidid><orcidid>https://orcid.org/0000-0002-0481-0989</orcidid><orcidid>https://orcid.org/0000-0001-5984-8127</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1660-4601 |
ispartof | International journal of environmental research and public health, 2021-04, Vol.18 (8), p.3865 |
issn | 1660-4601 1661-7827 1660-4601 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8067706 |
source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Ambiguity Anxiety Coping Grief Mathematical models Mental depression Mental disorders Mental health Murders & murder attempts Post traumatic stress disorder Psychological stress Psychopathology Questionnaires Refugees Regression analysis Statistical analysis |
title | Traumatized Syrian Refugees with Ambiguous Loss: Predictors of Mental Distress |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T15%3A12%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Traumatized%20Syrian%20Refugees%20with%20Ambiguous%20Loss:%20Predictors%20of%20Mental%20Distress&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Renner,%20Anna&rft.date=2021-04-07&rft.volume=18&rft.issue=8&rft.spage=3865&rft.pages=3865-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph18083865&rft_dat=%3Cproquest_pubme%3E2566046893%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2566046893&rft_id=info:pmid/33917058&rfr_iscdi=true |