Involvement of Local, Rapid Conformational Dynamics in Binding of Flexible Recognition Motifs

Flexible protein sequences populate ensembles of rapidly interconverting states differentiated by small-scale fluctuations; however, elucidating whether and how the ensembles determine function experimentally is challenged by the combined high spatial and temporal resolution needed to capture the st...

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Veröffentlicht in:	The journal of physical chemistry. B 2019-10, Vol.123 (40), p.8387-8396
Hauptverfasser:	Bukowski, Gregory S, Horness, Rachel E, Thielges, Megan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Entropy Kinetics Molecular Dynamics Simulation Peptides - chemistry Peptides - metabolism Proteins - chemistry Proteins - metabolism src Homology Domains
Online-Zugang:	Volltext
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