The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review-Gut Permeability as Potential Treatment Target
Muscle wasting is a frequently observed, inflammation-driven condition in aging and disease, known as sarcopenia and cachexia. Current treatment strategies target the muscle directly and are often not able to reverse the process. Because a reduced gut function is related to systemic inflammation, th...
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| Veröffentlicht in: | Nutrients 2021-03, Vol.13 (4), p.1115 |
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| creator | van Krimpen, Sandra J Jansen, Fleur A C Ottenheim, Veerle L Belzer, Clara van der Ende, Miranda van Norren, Klaske |
| description | Muscle wasting is a frequently observed, inflammation-driven condition in aging and disease, known as sarcopenia and cachexia. Current treatment strategies target the muscle directly and are often not able to reverse the process. Because a reduced gut function is related to systemic inflammation, this might be an indirect target to ameliorate muscle wasting, by administering pro-, pre-, and synbiotics. Therefore, this review aimed to study the potential of pro-, pre-, and synbiotics to treat muscle wasting and to elucidate which metabolites and mechanisms affect the organ crosstalk in cachexia. Overall, the literature shows that
(spp.) and possibly other genera, such as
, can ameliorate muscle wasting in mouse models. The beneficial effects of
spp. supplementation may be attributed to its potential to improve microbiome balance and to its reported capacity to reduce gut permeability. A subsequent literature search revealed that the reduction of a high gut permeability coincided with improved muscle mass or strength, which shows an association between gut permeability and muscle mass. A possible working mechanism is proposed, involving lactate, butyrate, and reduced inflammation in gut-brain-muscle crosstalk. Thus, reducing gut permeability via
spp. supplementation could be a potential treatment strategy for muscle wasting. |
| doi_str_mv | 10.3390/nu13041115 |
| format | Article |
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(spp.) and possibly other genera, such as
, can ameliorate muscle wasting in mouse models. The beneficial effects of
spp. supplementation may be attributed to its potential to improve microbiome balance and to its reported capacity to reduce gut permeability. A subsequent literature search revealed that the reduction of a high gut permeability coincided with improved muscle mass or strength, which shows an association between gut permeability and muscle mass. A possible working mechanism is proposed, involving lactate, butyrate, and reduced inflammation in gut-brain-muscle crosstalk. Thus, reducing gut permeability via
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(spp.) and possibly other genera, such as
, can ameliorate muscle wasting in mouse models. The beneficial effects of
spp. supplementation may be attributed to its potential to improve microbiome balance and to its reported capacity to reduce gut permeability. A subsequent literature search revealed that the reduction of a high gut permeability coincided with improved muscle mass or strength, which shows an association between gut permeability and muscle mass. A possible working mechanism is proposed, involving lactate, butyrate, and reduced inflammation in gut-brain-muscle crosstalk. Thus, reducing gut permeability via
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Jansen, Fleur A C ; Ottenheim, Veerle L ; Belzer, Clara ; van der Ende, Miranda ; van Norren, Klaske</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-ee75339356de53612364bd264ffd06a8596fb4ad24f52f0581a656c47b2ed4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Animal models</topic><topic>Cachexia</topic><topic>Cancer</topic><topic>Crosstalk</topic><topic>Disease</topic><topic>Homeostasis</topic><topic>Lactic acid</topic><topic>Lactobacillus</topic><topic>Leukemia</topic><topic>Medical treatment</topic><topic>Metabolites</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Muscle function</topic><topic>Muscle strength</topic><topic>Muscles</topic><topic>Permeability</topic><topic>Prebiotics</topic><topic>Probiotics</topic><topic>Proteins</topic><topic>Review</topic><topic>Sarcopenia</topic><topic>Systematic review</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Krimpen, Sandra J</creatorcontrib><creatorcontrib>Jansen, Fleur A C</creatorcontrib><creatorcontrib>Ottenheim, Veerle L</creatorcontrib><creatorcontrib>Belzer, Clara</creatorcontrib><creatorcontrib>van der Ende, Miranda</creatorcontrib><creatorcontrib>van Norren, Klaske</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Krimpen, Sandra J</au><au>Jansen, Fleur A C</au><au>Ottenheim, Veerle L</au><au>Belzer, Clara</au><au>van der Ende, Miranda</au><au>van Norren, Klaske</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review-Gut Permeability as Potential Treatment Target</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2021-03-29</date><risdate>2021</risdate><volume>13</volume><issue>4</issue><spage>1115</spage><pages>1115-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Muscle wasting is a frequently observed, inflammation-driven condition in aging and disease, known as sarcopenia and cachexia. Current treatment strategies target the muscle directly and are often not able to reverse the process. Because a reduced gut function is related to systemic inflammation, this might be an indirect target to ameliorate muscle wasting, by administering pro-, pre-, and synbiotics. Therefore, this review aimed to study the potential of pro-, pre-, and synbiotics to treat muscle wasting and to elucidate which metabolites and mechanisms affect the organ crosstalk in cachexia. Overall, the literature shows that
(spp.) and possibly other genera, such as
, can ameliorate muscle wasting in mouse models. The beneficial effects of
spp. supplementation may be attributed to its potential to improve microbiome balance and to its reported capacity to reduce gut permeability. A subsequent literature search revealed that the reduction of a high gut permeability coincided with improved muscle mass or strength, which shows an association between gut permeability and muscle mass. A possible working mechanism is proposed, involving lactate, butyrate, and reduced inflammation in gut-brain-muscle crosstalk. Thus, reducing gut permeability via
spp. supplementation could be a potential treatment strategy for muscle wasting.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33805286</pmid><doi>10.3390/nu13041115</doi><orcidid>https://orcid.org/0000-0001-7475-2625</orcidid><orcidid>https://orcid.org/0000-0002-8314-2543</orcidid><orcidid>https://orcid.org/0000-0002-6281-9455</orcidid><orcidid>https://orcid.org/0000-0001-9864-0505</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Animal models Cachexia Cancer Crosstalk Disease Homeostasis Lactic acid Lactobacillus Leukemia Medical treatment Metabolites Microbiomes Microbiota Microorganisms Muscle function Muscle strength Muscles Permeability Prebiotics Probiotics Proteins Review Sarcopenia Systematic review Therapeutic applications |
| title | The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review-Gut Permeability as Potential Treatment Target |
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