Population immunity and vaccine protection against infection
With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. [...]SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission. [...]a one-dose strategy might be b...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 2021-05, Vol.397 (10286), p.1685-1687 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1687 |
|---|---|
| container_issue | 10286 |
| container_start_page | 1685 |
| container_title | The Lancet (British edition) |
| container_volume | 397 |
| creator | Leshem, Eyal Lopman, Benjamin Alan |
| description | With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. [...]SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission. [...]a one-dose strategy might be best for averting the most deaths, but higher population immunity to quell transmission will require a full course of two doses. Presence of symptoms has a complex relationship with SARS‑CoV‑2 transmission, since asymptomatically infected people play a key role in spread.9 However, since breakthrough cases among vaccinated individuals shed virus at lower levels, they are probably less infectious than unvaccinated individuals are.3 Second, in this study population, participants who previously had COVID-19 were less likely to be vaccinated. |
| doi_str_mv | 10.1016/S0140-6736(21)00870-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8064666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673621008709</els_id><sourcerecordid>2518994545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-41934b45aaa1bfa42dfaabbf16f2ddbcee3827e05ce0c15c16e64d759ce1688b3</originalsourceid><addsrcrecordid>eNqFkV9L5DAUxYMoOrp-BKXgiz5UkzRJGxCXRfyzILigC_sW0vR2jLTJmLQDfnvjzDioL_sUyPndk9xzEDog-JRgIs4eMGE4F2Uhjik5wbgqcS430ISwkuWclf820WSN7KDdGJ8xxkxgvo12ikImjdIJOv_jZ2OnB-tdZvt-dHZ4zbRrsrk2xjrIZsEPYBa6nmrr4pBZ1y5vfqCtVncR9lfnHvp7ffV4eZvf3d_8vvx1lxsm-ZAzIgtWM661JnWrGW1areu6JaKlTVMbgKKiJWBuABvCDREgWFNyaYCIqqqLPXSx9J2NdQ-NATcE3alZsL0Or8prq74qzj6pqZ-rCgsmhEgGxyuD4F9GiIPqbTTQddqBH6OinFRSMs54Qo--oc9-DC6tlyhKuSyKkiaKLykTfIwB2vVnCFbv_ahFP-o9fEWJWvSjZJo7_LzJeuqjkAT8XAKQ8pxbCCoaC85AY0MKXTXe_ueJNyrNoWw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2522593372</pqid></control><display><type>article</type><title>Population immunity and vaccine protection against infection</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Leshem, Eyal ; Lopman, Benjamin Alan</creator><creatorcontrib>Leshem, Eyal ; Lopman, Benjamin Alan</creatorcontrib><description>With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. [...]SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission. [...]a one-dose strategy might be best for averting the most deaths, but higher population immunity to quell transmission will require a full course of two doses. Presence of symptoms has a complex relationship with SARS‑CoV‑2 transmission, since asymptomatically infected people play a key role in spread.9 However, since breakthrough cases among vaccinated individuals shed virus at lower levels, they are probably less infectious than unvaccinated individuals are.3 Second, in this study population, participants who previously had COVID-19 were less likely to be vaccinated.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(21)00870-9</identifier><identifier>PMID: 33901422</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antibodies, Viral ; Asymptomatic ; Asymptomatic infection ; Comment ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Disease transmission ; Ethnicity ; Herd immunity ; Humans ; Immunity ; Infections ; Population ; Population studies ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination ; Vaccines ; Viral diseases</subject><ispartof>The Lancet (British edition), 2021-05, Vol.397 (10286), p.1685-1687</ispartof><rights>2021 Elsevier Ltd</rights><rights>2021. Elsevier Ltd</rights><rights>2021 Elsevier Ltd. All rights reserved. 2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-41934b45aaa1bfa42dfaabbf16f2ddbcee3827e05ce0c15c16e64d759ce1688b3</citedby><cites>FETCH-LOGICAL-c495t-41934b45aaa1bfa42dfaabbf16f2ddbcee3827e05ce0c15c16e64d759ce1688b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673621008709$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33901422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leshem, Eyal</creatorcontrib><creatorcontrib>Lopman, Benjamin Alan</creatorcontrib><title>Population immunity and vaccine protection against infection</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. [...]SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission. [...]a one-dose strategy might be best for averting the most deaths, but higher population immunity to quell transmission will require a full course of two doses. Presence of symptoms has a complex relationship with SARS‑CoV‑2 transmission, since asymptomatically infected people play a key role in spread.9 However, since breakthrough cases among vaccinated individuals shed virus at lower levels, they are probably less infectious than unvaccinated individuals are.3 Second, in this study population, participants who previously had COVID-19 were less likely to be vaccinated.</description><subject>Antibodies, Viral</subject><subject>Asymptomatic</subject><subject>Asymptomatic infection</subject><subject>Comment</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 vaccines</subject><subject>Disease transmission</subject><subject>Ethnicity</subject><subject>Herd immunity</subject><subject>Humans</subject><subject>Immunity</subject><subject>Infections</subject><subject>Population</subject><subject>Population studies</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viral diseases</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV9L5DAUxYMoOrp-BKXgiz5UkzRJGxCXRfyzILigC_sW0vR2jLTJmLQDfnvjzDioL_sUyPndk9xzEDog-JRgIs4eMGE4F2Uhjik5wbgqcS430ISwkuWclf820WSN7KDdGJ8xxkxgvo12ikImjdIJOv_jZ2OnB-tdZvt-dHZ4zbRrsrk2xjrIZsEPYBa6nmrr4pBZ1y5vfqCtVncR9lfnHvp7ffV4eZvf3d_8vvx1lxsm-ZAzIgtWM661JnWrGW1areu6JaKlTVMbgKKiJWBuABvCDREgWFNyaYCIqqqLPXSx9J2NdQ-NATcE3alZsL0Or8prq74qzj6pqZ-rCgsmhEgGxyuD4F9GiIPqbTTQddqBH6OinFRSMs54Qo--oc9-DC6tlyhKuSyKkiaKLykTfIwB2vVnCFbv_ahFP-o9fEWJWvSjZJo7_LzJeuqjkAT8XAKQ8pxbCCoaC85AY0MKXTXe_ueJNyrNoWw</recordid><startdate>20210508</startdate><enddate>20210508</enddate><creator>Leshem, Eyal</creator><creator>Lopman, Benjamin Alan</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210508</creationdate><title>Population immunity and vaccine protection against infection</title><author>Leshem, Eyal ; Lopman, Benjamin Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-41934b45aaa1bfa42dfaabbf16f2ddbcee3827e05ce0c15c16e64d759ce1688b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibodies, Viral</topic><topic>Asymptomatic</topic><topic>Asymptomatic infection</topic><topic>Comment</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 vaccines</topic><topic>Disease transmission</topic><topic>Ethnicity</topic><topic>Herd immunity</topic><topic>Humans</topic><topic>Immunity</topic><topic>Infections</topic><topic>Population</topic><topic>Population studies</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leshem, Eyal</creatorcontrib><creatorcontrib>Lopman, Benjamin Alan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leshem, Eyal</au><au>Lopman, Benjamin Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population immunity and vaccine protection against infection</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2021-05-08</date><risdate>2021</risdate><volume>397</volume><issue>10286</issue><spage>1685</spage><epage>1687</epage><pages>1685-1687</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. [...]SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission. [...]a one-dose strategy might be best for averting the most deaths, but higher population immunity to quell transmission will require a full course of two doses. Presence of symptoms has a complex relationship with SARS‑CoV‑2 transmission, since asymptomatically infected people play a key role in spread.9 However, since breakthrough cases among vaccinated individuals shed virus at lower levels, they are probably less infectious than unvaccinated individuals are.3 Second, in this study population, participants who previously had COVID-19 were less likely to be vaccinated.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33901422</pmid><doi>10.1016/S0140-6736(21)00870-9</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2021-05, Vol.397 (10286), p.1685-1687 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8064666 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibodies, Viral Asymptomatic Asymptomatic infection Comment Coronaviruses COVID-19 COVID-19 vaccines Disease transmission Ethnicity Herd immunity Humans Immunity Infections Population Population studies Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccines Viral diseases |
| title | Population immunity and vaccine protection against infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T12%3A44%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Population%20immunity%20and%20vaccine%20protection%20against%20infection&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Leshem,%20Eyal&rft.date=2021-05-08&rft.volume=397&rft.issue=10286&rft.spage=1685&rft.epage=1687&rft.pages=1685-1687&rft.issn=0140-6736&rft.eissn=1474-547X&rft_id=info:doi/10.1016/S0140-6736(21)00870-9&rft_dat=%3Cproquest_pubme%3E2518994545%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2522593372&rft_id=info:pmid/33901422&rft_els_id=S0140673621008709&rfr_iscdi=true |