Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study
BackgroundThe triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is the most frequently used index. Few studies have evaluated the role of IR assessed by the TyG index a...
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| description | BackgroundThe triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is the most frequently used index. Few studies have evaluated the role of IR assessed by the TyG index and HOMA-IR on arterial stiffness in a type 2 diabetes (T2D) population with a high risk of increased arterial stiffness. We aimed to investigate the association of the TyG index and HOMA-IR with arterial stiffness in patients with T2D.
MethodsWe recruited 3185 patients with T2D, who underwent brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, but without previous cardiovascular disease. Increased arterial stiffness was defined as a baPWV value greater than the 75th percentile (18.15 m/s) in the present study. The TyG index was determined as ln(fasting triglycerides [mg/dL]xfasting glucose [mg/dL]/2), and the HOMA-IR was calculated as (fasting insulin [mu IU/mL]xfasting glucose [mmol/L])/22.5.
ResultsThe mean age of the study participants was 54.612.0 years, and 1954 (61.4%) were men. Seemingly unrelated regression estimation analysis demonstrated that the TyG index had stronger associations with baPWV than the HOMA-IR (all P |
| doi_str_mv | 10.1186/s12933-021-01274-x |
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MethodsWe recruited 3185 patients with T2D, who underwent brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, but without previous cardiovascular disease. Increased arterial stiffness was defined as a baPWV value greater than the 75th percentile (18.15 m/s) in the present study. The TyG index was determined as ln(fasting triglycerides [mg/dL]xfasting glucose [mg/dL]/2), and the HOMA-IR was calculated as (fasting insulin [mu IU/mL]xfasting glucose [mmol/L])/22.5.
ResultsThe mean age of the study participants was 54.612.0 years, and 1954 (61.4%) were men. Seemingly unrelated regression estimation analysis demonstrated that the TyG index had stronger associations with baPWV than the HOMA-IR (all P<0.001). In the multivariable logistic analyses, each one-unit increase in the TyG index was associated with a 1.40-fold (95% CI 1.16-1.70, P<0.001) higher prevalence of increased arterial stiffness, but the prominent association of the HOMA-IR with the prevalence of increased arterial stiffness was not observed. Subgroup analyses showed that a more significant association between the TyG index and the prevalence of increased arterial stiffness was detected in older patients with a longer duration of diabetes and poor glycaemic control (all P<0.05).
Conclusions Compared with the HOMA-IR, the TyG index is independently and more strongly associated with arterial stiffness in patients with T2D.</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/s12933-021-01274-x</identifier><identifier>PMID: 33888131</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Ankle ; Antihypertensives ; Arterial stiffness ; Automation ; Blood pressure ; Brachial-ankle pulse wave velocity ; Cardiac & Cardiovascular Systems ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular System & Cardiology ; Cholesterol ; Creatinine ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Endocrinology & Metabolism ; Fasting ; Generalized linear models ; Glucose ; Homeostasis ; Hypertension ; Immunoassay ; Insulin ; Insulin resistance ; Laboratories ; Laboratory testing ; Life Sciences & Biomedicine ; Metabolism ; Original Investigation ; Science & Technology ; Triglyceride glucose index ; Triglycerides ; Type 2 diabetes ; Variables</subject><ispartof>Cardiovascular diabetology, 2021-04, Vol.20 (1), p.82-82, Article 82</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>105</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000644075400002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c496t-dae7f18f132464d105fb3edb54c3c28f69d34f81d8321cac1d17d828436ac3c3</citedby><cites>FETCH-LOGICAL-c496t-dae7f18f132464d105fb3edb54c3c28f69d34f81d8321cac1d17d828436ac3c3</cites><orcidid>0000-0001-8838-4771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063289/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063289/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33888131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shujie</creatorcontrib><creatorcontrib>Shi, Juan</creatorcontrib><creatorcontrib>Peng, Ying</creatorcontrib><creatorcontrib>Fang, Qianhua</creatorcontrib><creatorcontrib>Mu, Qian</creatorcontrib><creatorcontrib>Gu, Weiqiong</creatorcontrib><creatorcontrib>Hong, Jie</creatorcontrib><creatorcontrib>Zhang, Yifei</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><title>Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study</title><title>Cardiovascular diabetology</title><addtitle>CARDIOVASC DIABETOL</addtitle><addtitle>Cardiovasc Diabetol</addtitle><description>BackgroundThe triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is the most frequently used index. Few studies have evaluated the role of IR assessed by the TyG index and HOMA-IR on arterial stiffness in a type 2 diabetes (T2D) population with a high risk of increased arterial stiffness. We aimed to investigate the association of the TyG index and HOMA-IR with arterial stiffness in patients with T2D.
MethodsWe recruited 3185 patients with T2D, who underwent brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, but without previous cardiovascular disease. Increased arterial stiffness was defined as a baPWV value greater than the 75th percentile (18.15 m/s) in the present study. The TyG index was determined as ln(fasting triglycerides [mg/dL]xfasting glucose [mg/dL]/2), and the HOMA-IR was calculated as (fasting insulin [mu IU/mL]xfasting glucose [mmol/L])/22.5.
ResultsThe mean age of the study participants was 54.612.0 years, and 1954 (61.4%) were men. Seemingly unrelated regression estimation analysis demonstrated that the TyG index had stronger associations with baPWV than the HOMA-IR (all P<0.001). In the multivariable logistic analyses, each one-unit increase in the TyG index was associated with a 1.40-fold (95% CI 1.16-1.70, P<0.001) higher prevalence of increased arterial stiffness, but the prominent association of the HOMA-IR with the prevalence of increased arterial stiffness was not observed. Subgroup analyses showed that a more significant association between the TyG index and the prevalence of increased arterial stiffness was detected in older patients with a longer duration of diabetes and poor glycaemic control (all P<0.05).
Conclusions Compared with the HOMA-IR, the TyG index is independently and more strongly associated with arterial stiffness in patients with T2D.</description><subject>Ankle</subject><subject>Antihypertensives</subject><subject>Arterial stiffness</subject><subject>Automation</subject><subject>Blood pressure</subject><subject>Brachial-ankle pulse wave velocity</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular System & Cardiology</subject><subject>Cholesterol</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Endocrinology & Metabolism</subject><subject>Fasting</subject><subject>Generalized linear models</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Hypertension</subject><subject>Immunoassay</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Laboratory testing</subject><subject>Life Sciences & Biomedicine</subject><subject>Metabolism</subject><subject>Original Investigation</subject><subject>Science & Technology</subject><subject>Triglyceride glucose index</subject><subject>Triglycerides</subject><subject>Type 2 diabetes</subject><subject>Variables</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkt9u0zAUhyMEYmPwAlwgS9wgoYD_JXG4QJoqYJWGJsHuLdc-aV2lcbEd2r4Mz8qhGdXGFTe2ZX_-7GP_iuIlo-8YU_X7xHgrREk5KynjjSz3j4pzJpuq5ErSx_fGZ8WzlNaUskbV7GlxJoRSigl2Xvz6nmMYlhCJSSlYb7IPAwkdydEv-4OF6B2QZT_akID4wcGe5JUZsAFydfP1spx_IzufV8TEjLDpScq-6wZICXGyRSEMOU1MPmyBcOK8WUCG9IEYEsH05S7E3pHkh2UPpUU-AmpGd3hePOlMn-DFXX9R3H7-dDu7Kq9vvsxnl9ellW2dS2eg6ZjqmOCylo7RqlsIcItKWmG56urWCdkp5pTgzBrLHGucwpcRtUFCXBTzSeuCWett9BsTDzoYr48TIS41ludtD9qiyIJqrVSdrNrWCNdQJvBEymnrKnR9nFzbcbEBd6zG9A-kD1cGv9LL8FMrWguuWhS8uRPE8GOElPXGJwt9bwYIY9K8YqqSDRUS0df_oOswxgFfCimuVFvjnyPFJ8rGkFKE7nQZRvWfJOkpSRqTpI9J0nvc9Op-Gactf6ODwNsJ2MEidMniN1s4YZTSWkraVBJHlCOt_p-e-XzM4SyMQxa_Ae3E588</recordid><startdate>20210422</startdate><enddate>20210422</enddate><creator>Wang, Shujie</creator><creator>Shi, Juan</creator><creator>Peng, Ying</creator><creator>Fang, Qianhua</creator><creator>Mu, Qian</creator><creator>Gu, Weiqiong</creator><creator>Hong, Jie</creator><creator>Zhang, Yifei</creator><creator>Wang, Weiqing</creator><general>Springer Nature</general><general>BioMed Central</general><general>BMC</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8838-4771</orcidid></search><sort><creationdate>20210422</creationdate><title>Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study</title><author>Wang, Shujie ; Shi, Juan ; Peng, Ying ; Fang, Qianhua ; Mu, Qian ; Gu, Weiqiong ; Hong, Jie ; Zhang, Yifei ; Wang, Weiqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-dae7f18f132464d105fb3edb54c3c28f69d34f81d8321cac1d17d828436ac3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ankle</topic><topic>Antihypertensives</topic><topic>Arterial stiffness</topic><topic>Automation</topic><topic>Blood pressure</topic><topic>Brachial-ankle pulse wave velocity</topic><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular System & Cardiology</topic><topic>Cholesterol</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Endocrinology & Metabolism</topic><topic>Fasting</topic><topic>Generalized linear models</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Hypertension</topic><topic>Immunoassay</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Laboratory testing</topic><topic>Life Sciences & Biomedicine</topic><topic>Metabolism</topic><topic>Original Investigation</topic><topic>Science & Technology</topic><topic>Triglyceride glucose index</topic><topic>Triglycerides</topic><topic>Type 2 diabetes</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shujie</creatorcontrib><creatorcontrib>Shi, Juan</creatorcontrib><creatorcontrib>Peng, Ying</creatorcontrib><creatorcontrib>Fang, Qianhua</creatorcontrib><creatorcontrib>Mu, Qian</creatorcontrib><creatorcontrib>Gu, Weiqiong</creatorcontrib><creatorcontrib>Hong, Jie</creatorcontrib><creatorcontrib>Zhang, Yifei</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cardiovascular diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shujie</au><au>Shi, Juan</au><au>Peng, Ying</au><au>Fang, Qianhua</au><au>Mu, Qian</au><au>Gu, Weiqiong</au><au>Hong, Jie</au><au>Zhang, Yifei</au><au>Wang, Weiqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study</atitle><jtitle>Cardiovascular diabetology</jtitle><stitle>CARDIOVASC DIABETOL</stitle><addtitle>Cardiovasc Diabetol</addtitle><date>2021-04-22</date><risdate>2021</risdate><volume>20</volume><issue>1</issue><spage>82</spage><epage>82</epage><pages>82-82</pages><artnum>82</artnum><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>BackgroundThe triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is the most frequently used index. Few studies have evaluated the role of IR assessed by the TyG index and HOMA-IR on arterial stiffness in a type 2 diabetes (T2D) population with a high risk of increased arterial stiffness. We aimed to investigate the association of the TyG index and HOMA-IR with arterial stiffness in patients with T2D.
MethodsWe recruited 3185 patients with T2D, who underwent brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, but without previous cardiovascular disease. Increased arterial stiffness was defined as a baPWV value greater than the 75th percentile (18.15 m/s) in the present study. The TyG index was determined as ln(fasting triglycerides [mg/dL]xfasting glucose [mg/dL]/2), and the HOMA-IR was calculated as (fasting insulin [mu IU/mL]xfasting glucose [mmol/L])/22.5.
ResultsThe mean age of the study participants was 54.612.0 years, and 1954 (61.4%) were men. Seemingly unrelated regression estimation analysis demonstrated that the TyG index had stronger associations with baPWV than the HOMA-IR (all P<0.001). In the multivariable logistic analyses, each one-unit increase in the TyG index was associated with a 1.40-fold (95% CI 1.16-1.70, P<0.001) higher prevalence of increased arterial stiffness, but the prominent association of the HOMA-IR with the prevalence of increased arterial stiffness was not observed. Subgroup analyses showed that a more significant association between the TyG index and the prevalence of increased arterial stiffness was detected in older patients with a longer duration of diabetes and poor glycaemic control (all P<0.05).
Conclusions Compared with the HOMA-IR, the TyG index is independently and more strongly associated with arterial stiffness in patients with T2D.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>33888131</pmid><doi>10.1186/s12933-021-01274-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8838-4771</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ankle Antihypertensives Arterial stiffness Automation Blood pressure Brachial-ankle pulse wave velocity Cardiac & Cardiovascular Systems Cardiovascular disease Cardiovascular diseases Cardiovascular System & Cardiology Cholesterol Creatinine Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology & Metabolism Fasting Generalized linear models Glucose Homeostasis Hypertension Immunoassay Insulin Insulin resistance Laboratories Laboratory testing Life Sciences & Biomedicine Metabolism Original Investigation Science & Technology Triglyceride glucose index Triglycerides Type 2 diabetes Variables |
| title | Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study |
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