Assessment of a Polygenic Risk Score for Colorectal Cancer to Predict Risk of Lynch Syndrome Colorectal Cancer

Abstract It was not known whether the polygenic risk scores (PRSs) that predict colorectal cancer could predict colorectal cancer for people with inherited pathogenic variants in DNA mismatch repair genes—people with Lynch syndrome. We tested a PRS comprising 107 established single-nucleotide polymo...

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Veröffentlicht in:	JNCI cancer spectrum 2021-04, Vol.5 (2)
Hauptverfasser:	Jenkins, Mark A, Buchanan, Daniel D, Lai, John, Makalic, Enes, Dite, Gillian S, Win, Aung K, Clendenning, Mark, Winship, Ingrid M, Hayes, Richard B, Huyghe, Jeroen R, Peters, Ulrike, Gallinger, Steven, Marchand, Loïc Le, Figueiredo, Jane C, Pai, Rish K, Newcomb, Polly A, Church, James M, Casey, Graham, Hopper, John L
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief Communications Colorectal Neoplasms - ethnology Colorectal Neoplasms - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - ethnology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Mismatch Repair - genetics DNA-Binding Proteins - genetics Epithelial Cell Adhesion Molecule - genetics Europe - ethnology Female Humans Male Middle Aged Mismatch Repair Endonuclease PMS2 - genetics MutL Protein Homolog 1 - genetics MutS Homolog 2 Protein - genetics Polymorphism, Single Nucleotide Risk Assessment Risk Factors
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